ChemicalBook >> CAS DataBase List >>GNE-6640
GNE-6640
- CAS No.
- 2009273-67-8
- Chemical Name:
- GNE-6640
- Synonyms
- CS-2824;GNE-6641;GNE-6640, 10 mM in DMSO;GNE-6640;GNE 6640;GNE6640;2009273-67-8;4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol;Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-;Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640
- CBNumber:
- CB64693453
- Molecular Formula:
- C20H18N4O
- Molecular Weight:
- 330.38
- MDL Number:
- MFCD31807618
- MOL File:
- 2009273-67-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Product description | Number | Pack Size | Price |
| GNE-6640 ≥98% | 33751 | 5mg | $134 |
| GNE-6640 ≥98% | 33751 | 10mg | $213 |
| GNE-6640 ≥98% | 33751 | 25mg | $301 |
| GNE-6640 ≥98% | 33751 | 50mg | $530 |
| GNE-6640 | JFD27367 | 25mg | $1293.25 |
| More product size | |||
| Boiling point | 595.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.308±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMF:1.0(Max Conc. mg/mL);3.03(Max Conc. mM) DMSO:3.0(Max Conc. mg/mL);9.08(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM) |
| form | A solid |
| pka | 8.23±0.15(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H317-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P333+P313-P337+P313-P363-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
GNE-6640 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33751 | GNE-6640 ≥98% | 2009273-67-8 | 5mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 33751 | GNE-6640 ≥98% | 2009273-67-8 | 10mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 33751 | GNE-6640 ≥98% | 2009273-67-8 | 25mg | $301 | 2026-04-30 | Buy |
| Cayman Chemical | 33751 | GNE-6640 ≥98% | 2009273-67-8 | 50mg | $530 | 2026-04-30 | Buy |
| Biosynth | JFD27367 | GNE-6640 | 2009273-67-8 | 25mg | $1293.25 | 2026-06-04 | Buy |
GNE-6640 Chemical Properties,Uses,Production
Uses
GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].
References
[1] Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538. DOI:10.1038/nature24006
[2] Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639. DOI:10.1007/s00280-020-04046-8
GNE-6640 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4854 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 3000 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
CS-2824
GNE-6640;GNE 6640;GNE6640;2009273-67-8
Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-
GNE-6641
Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640
4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol
GNE-6640, 10 mM in DMSO
2009273-67-8
