T-2 TOXIN
- CAS No.
- 21259-20-1
- Chemical Name:
- T-2 TOXIN
- Synonyms
- toxint2;Toxin T 2;hothecene;nsc138780;T-2 TOXIN;T-2 toxins;alerate[qr];FUSARITOXIN;t-2mycotoxin;Insariotoxin
- CBNumber:
- CB6469458
- Molecular Formula:
- C24H34O9
- Molecular Weight:
- 466.52
- MDL Number:
- MFCD00871255
- MOL File:
- 21259-20-1.mol
- MSDS File:
- SDS
| Melting point | 151.5℃ |
|---|---|
| alpha | D26 +15° (c = 2.58 in ethanol) |
| Boiling point | 489.35°C (rough estimate) |
| Density | 1.1942 (rough estimate) |
| refractive index | 1.6230 (estimate) |
| Flash point | 2 °C |
| storage temp. | −20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml |
| form | powder |
| pka | 13.24±0.70(Predicted) |
| color | white |
| Merck | 13,9872 |
| Henry's Law Constant | 1.8×1012 mol/(m3Pa) at 25℃, HSDB (2015) |
| Major Application |
cleaning products cosmetics food and beverages personal care |
| InChIKey | BXFOFFBJRFZBQZ-QYWOHJEZSA-N |
| SMILES | C[C@@]12[C@@H]([C@H]([C@@]([H])(O[C@]3([H])C=C([C@H](C[C@]13COC(=O)C)OC(=O)CC(C)C)C)[C@@]12OC1)O)OC(=O)C |
| FDA UNII | I3FL5NM3MO |
| IARC | 3 (Vol. 31, Sup 7) 1987 |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T+,T,Xn,F | |||||||||
| Risk Statements | 26/27/28-38-36-20/21/22-11 | |||||||||
| Safety Statements | 28-36/37-45-36-26-16-36/37/39-22 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YD0100000 | |||||||||
| F | 10-21 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
|||||||||
| Hazardous Substances Data | 21259-20-1(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer) | |||||||||
| NFPA 704 |
|
T-2 TOXIN price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11444 | T-2 Toxin ≥95% | 21259-20-1 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 11444 | T-2 Toxin ≥95% | 21259-20-1 | 5mg | $229 | 2026-04-30 | Buy |
| TRC | TRC-T002980-5MG | T-2 Toxin | 21259-20-1 | 5mg | $200 | 2026-06-03 | Buy |
| TRC | TRC-T002980-50MG | T-2 Toxin | 21259-20-1 | 50mg | $1785 | 2026-06-03 | Buy |
| TRC | TRC-T002980-1MG | T-2 Toxin | 21259-20-1 | 1mg | $81 | 2026-06-03 | Buy |
T-2 TOXIN Chemical Properties,Uses,Production
Description
T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
Chemical Properties
White powder
Uses
T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.
Definition
ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.
General Description
T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.
Safety Profile
Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
References
[1] KUNIO DOI Koji U. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways.[J]. International Journal of Molecular Sciences, 2011, 12 8: 5213-5237. DOI: 10.3390/ijms12085213
[2] JULIE SEEBOTH. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig.[J]. Veterinary Research, 2012: 35. DOI: 10.1186/1297-9716-43-35
T-2 TOXIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Qingdao IniKem BioPharmaTech Co.,Ltd | 0532-58268781 18561687109 | sales@inikem.com | China | 298 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
