MS0022
- CAS No.
- 691392-89-9
- Chemical Name:
- MS0022
- Synonyms
- MS0022;Benzamide, 2-bromo-N-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-
- CBNumber:
- CB64919746
- Molecular Formula:
- C21H16BrN3O
- Molecular Weight:
- 406.28
- MDL Number:
- MOL File:
- 691392-89-9.mol
- MSDS File:
- SDS
MS0022 Chemical Properties, Uses, Production
Description
MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo.
Uses
MS-0022 is a Smoothened (SMO) antagonist. MS-0022 can inhibit the Hedgehog (Hh) signaling pathway. MS-0022 can be used in anti-tumor research[1].
References
[1] Strand MF, et al. A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model. PLoS One. 2011;6(6):e19904. DOI:10.1371/journal.pone.0019904
MS0022 Preparation Products And Raw materials
Raw materials
Preparation Products
MS0022 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
