SB 220025 trihydrochloride
- CAS No.
- 197446-75-6
- Chemical Name:
- SB 220025 trihydrochloride
- Synonyms
- SB 220025 trihydrochloride >=98% (HPLC), solid;SB 220025 trihydrochloride,SB220025 trihydrochloride
- CBNumber:
- CB6498405
- Molecular Formula:
- C18H19FN6.3ClH
- Molecular Weight:
- 447.771
- MDL Number:
- MFCD08705333
- MOL File:
- 197446-75-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| solubility | H2O: 22 mg/mL |
|---|---|
| form | solid |
| color | white |
| Water Solubility | H2O: 22mg/mL |
| InChI | 1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H |
| InChIKey | IPFBHUGKKONHFR-UHFFFAOYSA-N |
| SMILES | Cl[H].Cl[H].Cl[H].Nc1nccc(n1)-c2c(ncn2C3CCNCC3)-c4ccc(F)cc4 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P261-P301+P310-P305+P351+P338 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
SB 220025 trihydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S9070 | SB 220025 trihydrochloride ≥98%(HPLC),solid | 197446-75-6 | 500μg | $195 | 2026-04-30 | Buy |
| Sigma-Aldrich | S9070 | SB 220025 trihydrochloride ≥98% (HPLC), solid | 197446-75-6 | 2mg | $461 | 2026-04-30 | Buy |
| American Custom Chemicals Corporation | API0007585 | SB 220025 TRIHYDROCHLORIDE 95.00% | 197446-75-6 | 2MG | $1010.63 | 2021-12-16 | Buy |
SB 220025 trihydrochloride Chemical Properties, Uses, Production
Uses
SB 220025 trihydrochloride may be used in p38-mediated cell signaling studies.
Biological Activity
SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. SB 220025 reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 reduced the lipopolysaccharide-induced production of TNF at an ED50 value of 7.5 mg/kg. at 30 mg/kg, SB 220025 reduced the expression of TNF and inhibited angiogenesis by ~40%. In a further study, the effects of p38/CSBP MAP kinase inhibition in angiogenesis-dependent chronic inflammatory disease was tested in murine collagen-induced arthritis and SB 220025 was able to prevent the progression of established arthritis.
SB 220025 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
SB 220025 trihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19684 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Jinan ponder chemical co. LTD | 58 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from SB 220025 trihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | SB-220025 trihydrochloride
197446-75-6
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- SB-220025 trihydrochloride
197446-75-6
- $1520.00-2500.00
- TargetMol Chemicals Inc.
