2-Bromoresorcinol
- CAS No.
- 6751-75-3
- Chemical Name:
- 2-Bromoresorcinol
- Synonyms
- 2-bromobenzene-1,3-diol;2-Bromoresorcinol;2-Bromoresorcinol 95%;2-BroMo-1,3-benzenediol;1,3-Benzenediol, 2-bromo-;2-BroMo-1,3-dihydroxybenzene
- CBNumber:
- CB6500618
- Molecular Formula:
- C6H5BrO2
- Molecular Weight:
- 189.01
- MDL Number:
- MFCD07779241
- MOL File:
- 6751-75-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 96-103℃ |
|---|---|
| Boiling point | 235.3±20.0℃ (760 Torr) |
| Density | 1.844±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 96.1±21.8℃ |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| pka | 7.91±0.10(Predicted) |
| form | powder to crystaline |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C6H5BrO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H |
| InChIKey | UOLPZAPIFFZLMF-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=CC(O)=C1Br |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2908190090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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2-Bromoresorcinol price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 750778 | 2-Bromoresorcinol 95% | 6751-75-3 | 5g | $108 | 2026-04-30 | Buy |
| TCI Chemical | B5737 | 2-Bromoresorcinol | 6751-75-3 | 1G | $41 | 2026-04-30 | Buy |
| TCI Chemical | B5737 | 2-Bromoresorcinol | 6751-75-3 | 5G | $166 | 2026-04-30 | Buy |
| Biosynth | GAA75175 | 2-Bromoresorcinol | 6751-75-3 | 25g | $295 | 2026-06-04 | Buy |
| Activate Scientific | AS48427 | 2-Bromobenzene-1,3-diol 97% | 6751-75-3 | 1g | $25 | 2026-06-04 | Buy |
2-Bromoresorcinol Chemical Properties, Uses, Production
Uses
2-Bromoresorcinol is a key intermediate in the treatment of hepatitis C, specifically clopipvir hydrochloride, a pan-genotypic NS5A replication complex inhibitor that can be used in combination with sofosbuvir for the treatment of chronic hepatitis C in adults. Therefore, the development of 2-bromocatechol has a promising market prospect.
Synthesis
To 500 ml four-necked bottle successively added 170 g of toluene and 9.4 g of tert-butylamine, cooled down to -30 , 10.4 g of bromine slowly added dropwise, drop after drop, and then cooled down to -60 , dropwise addition of dichloromethane solution of catechol, drop after a natural warming to room temperature reaction for 24 hours, the sample is sent to the control of the HPLC; the end of the reaction, saturated sodium bisulfite quenched, dilute hydrochloric acid to adjust the pH = 1, toluene Toluene extraction, spinning to remove toluene; crude product and then distillation under reduced pressure to obtain the compound 2-bromocatechol. Yield 74-80%, HPLC 98%. This method is simple, safe and reliable, with high yield, suitable for industrialized production and the synthesis of 3-bromocatechol, which is a pharmaceutical intermediate with large socio-economic and environmental benefits.
Properties and Applications
The cyclocondensation of 2-bromoresorcinol with some aldehydes proceeds in acetonitrile-CF3SO3H to give cyclic tetramers with high stereoselectivity. 2-bromoresorcinol, C6H5BrO2, are essentially planar and possess normal geometrical parameters. The crystal packing is influenced by O-H...O and O-H...O/Br hydrogen bonds and pi-pi stacking interactions, resulting in a distinctive high-symmetry structure containing R(4)(4)(8) rings and helical C(2) chains[1-2].
References
[1] Peter Kirsop, William T A Harrison, John M D Storey. “1-Bromo-2,6-dihydroxybenzene containing R(4)(4)(8) rings and C(2) helices.” Acta crystallographica. Section C, Crystal structure communications 60 Pt 5 (2004): o353-5.
[2] Osamu Morikawa. “Trifluoromethanesulfonic acid-catalyzed synthesis of resorcinarenes: Cyclocondensation of 2-bromoresorcinol with aldehydes.” Synthesis-Stuttgart 40 1 (2002): 761–765.
2-Bromoresorcinol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromoresorcinol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei duofang Technology Co. , Ltd. | 13127301785 | 1720153048@qq.com | China | 499 | 58 |
| Changzhou Jiuwu Chemical co., Ltd. | 13775162768 | 16356194@qq.com | China | 28 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| NOTA Chemical (Shanghai) Co.,Ltd | 021-50189163 | sales@notachem.com | China | 208 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
View Latest Price from 2-Bromoresorcinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Bromo-1,3-benzenediol
6751-75-3
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2023-06-17 | 2-BROMORESORCINOL
6751-75-3
|
25KG | 99.0% | 5000KG/th | Zibo Shiji Zhonglian Medical Technology Co., Ltd. | ||
 |
2020-01-13 | 2-BROMORESORCINOL
6751-75-3
|
$5.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-Bromo-1,3-benzenediol
6751-75-3
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-BROMORESORCINOL
6751-75-3
- $0.00
- 99.0%
- Zibo Shiji Zhonglian Medical Technology Co., Ltd.
-
- 2-BROMORESORCINOL
6751-75-3
- $5.00
- 98%
- Career Henan Chemical Co
