2-Bromoresorcinol manufacturers
- 2-BROMORESORCINOL
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2023-06-17
- CAS:6751-75-3
- Min. Order: 25KG
- Purity: 99.0%
- Supply Ability: 5000KG/th
- 2-BROMORESORCINOL
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- $5.00
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2020-01-13
- CAS:6751-75-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| | 2-Bromoresorcinol Basic information |
| | 2-Bromoresorcinol Chemical Properties |
| Melting point | 96-103℃ | | Boiling point | 235.3±20.0℃ (760 Torr) | | density | 1.844±0.06 g/cm3 (20 ºC 760 Torr) | | Fp | 96.1±21.8℃ | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | pka | 7.91±0.10(Predicted) | | form | powder to crystaline | | color | White to Yellow to Orange | | InChI | InChI=1S/C6H5BrO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H | | InChIKey | UOLPZAPIFFZLMF-UHFFFAOYSA-N | | SMILES | C1(O)=CC=CC(O)=C1Br |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 2908190090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Bromoresorcinol Usage And Synthesis |
| Synthesis | To 500 ml four-necked bottle successively added 170 g of toluene and 9.4 g of tert-butylamine, cooled down to -30 , 10.4 g of bromine slowly added dropwise, drop after drop, and then cooled down to -60 , dropwise addition of dichloromethane solution of catechol, drop after a natural warming to room temperature reaction for 24 hours, the sample is sent to the control of the HPLC; the end of the reaction, saturated sodium bisulfite quenched, dilute hydrochloric acid to adjust the pH = 1, toluene Toluene extraction, spinning to remove toluene; crude product and then distillation under reduced pressure to obtain the compound 2-bromocatechol. Yield 74-80%, HPLC 98%. This method is simple, safe and reliable, with high yield, suitable for industrialized production and the synthesis of 3-bromocatechol, which is a pharmaceutical intermediate with large socio-economic and environmental benefits. | | Properties and Applications | The cyclocondensation of 2-bromoresorcinol with some aldehydes proceeds in acetonitrile-CF3SO3H to give cyclic tetramers with high stereoselectivity. 2-bromoresorcinol, C6H5BrO2, are essentially planar and possess normal geometrical parameters. The crystal packing is influenced by O-H...O and O-H...O/Br hydrogen bonds and pi-pi stacking interactions, resulting in a distinctive high-symmetry structure containing R(4)(4)(8) rings and helical C(2) chains[1-2].
| | References |
[1] Peter Kirsop, William T A Harrison, John M D Storey. “1-Bromo-2,6-dihydroxybenzene containing R(4)(4)(8) rings and C(2) helices.” Acta crystallographica. Section C, Crystal structure communications 60 Pt 5 (2004): o353-5.
[2] Osamu Morikawa. “Trifluoromethanesulfonic acid-catalyzed synthesis of resorcinarenes: Cyclocondensation of 2-bromoresorcinol with aldehydes.” Synthesis-Stuttgart 40 1 (2002): 761–765.
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| | 2-Bromoresorcinol Preparation Products And Raw materials |
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