CMLD012612
- CAS No.
- 2368900-35-8
- Chemical Name:
- CMLD012612
- Synonyms
- CMLD012612;CMLD012612,CMLD-012612
- CBNumber:
- CB65821264
- Molecular Formula:
- C31H33N3O7
- Molecular Weight:
- 559.61
- MDL Number:
- MFCD34469621
- MOL File:
- 2368900-35-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
CMLD012612 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | TUD90035 | CMLD012612 | 2368900-35-8 | 5mg | $970.25 | 2026-06-05 | Buy |
| Biosynth | TUD90035 | CMLD012612 | 2368900-35-8 | 10mg | $1349.9 | 2026-06-05 | Buy |
| Biosynth | TUD90035 | CMLD012612 | 2368900-35-8 | 25mg | $2531 | 2026-06-05 | Buy |
| Biosynth | TUD90035 | CMLD012612 | 2368900-35-8 | 50mg | $4050 | 2026-06-05 | Buy |
| ApexBio Technology | BA4103 | CMLD012612 | 2368900-35-8 | 1mg | $1485 | 2026-05-06 | Buy |
CMLD012612 Chemical Properties, Uses, Production
Uses
CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity[1].
in vivo
CMLD012612 (0.5 mg/kg; intraperitoneal injection; for 3 hours; female C57BL/6 mice) treatment effectively suppresses liver polysomes 3 hours after injection, indicating inhibitory activity toward protein synthesis[1].
When administered to mice bearing myr-Akt/Em-Myc lymphomas, CMLD012612 (0.2 mg/kg; intraperitoneal injection; daily; for 5 days; female C57BL/6 mice) treatment effectively synergizes with Doxorubicin, leading to complete tumor loss[1].
| Animal Model: | Female C57BL/6 mice[1] |
| Dosage: | 0.5 mg/kg |
| Administration: | Intraperitoneal injection; for 3 hours |
| Result: | Effectively suppressed liver polysomes 3 hours after injection. |
IC 50
eIF4
References
[1] Chu J, et al. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593. DOI:10.1016/j.chembiol.2019.08.008
CMLD012612 Preparation Products And Raw materials
Raw materials
Preparation Products
CMLD012612 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
View Latest Price from CMLD012612 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | CMLD012612
2368900-35-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | CMLD012612
2368900-35-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- CMLD012612
2368900-35-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
-
- CMLD012612
2368900-35-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
