HS79
- CAS No.
- 2138838-56-7
- Chemical Name:
- HS79
- Synonyms
- HS79;HS79,HS-79;N-[(3R)-1-Benzylpyrrolidin-3-yl]-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-
- CBNumber:
- CB65821446
- Molecular Formula:
- C19H22N4S
- Molecular Weight:
- 338.47
- MDL Number:
- MFCD31692396
- MOL File:
- 2138838-56-7.mol
HS79 Chemical Properties,Uses,Production
Uses
HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM.
Definition
ChEBI: (R)-Fasnall is an N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine in which the chiral centre has R configuration. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer. It has a role as a fatty acid synthesis inhibitor and an EC 2.3.1.85 (fatty acid synthase) inhibitor. It is an enantiomer of a (S)-Fasnall.
References
[1] Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88. DOI:10.1016/j.chembiol.2016.04.011
HS79 Preparation Products And Raw materials
Raw materials
Preparation Products
HS79 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 1666 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 26070 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
