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Boc-Val-Ala-PAB-PNP

Boc-Val-Ala-PAB-PNP structure

CAS No.: 1884578-00-0

Chemical Name:: Boc-Val-Ala-PAB-PNP

Synonyms: tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate;Boc-Val-Ala-PAB-PNP;Boc-Val-Ala-PAB-PNP USP/EP/BP;6-Maleimidohexanoyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)-carbonate;4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate;L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;[4-[[(2S)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

CBNumber:: CB65864429

Molecular Formula:: C27H34N4O9

Molecular Weight:: 558.58

MDL Number:: MFCD28557281

MOL File:: 1884578-00-0.mol

MSDS File:: SDS

Last updated:2026-09-10 08:17:50

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Boc-Val-Ala-PAB-PNP Properties

Boiling point	793.1±60.0 °C(Predicted)
Density	1.269±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	11.26±0.46(Predicted)
form	Solid
color	White to off-white
InChIKey	LEJLPYDPVFXXEM-JTSKRJEESA-N
SMILES	C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Boc-Val-Ala-PAB-PNP price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0119068	Boc-Val-Ala-PAB-PNP ≥98%	1884578-00-0	100mg	$156	2026-06-04	Buy
ChemScene	CS-0119068	Boc-Val-Ala-PAB-PNP ≥98%	1884578-00-0	250mg	$257	2026-06-04	Buy
ChemScene	CS-0119068	Boc-Val-Ala-PAB-PNP ≥98%	1884578-00-0	1g	$920	2026-06-04	Buy
ChemScene	CS-0119068	Boc-Val-Ala-PAB-PNP ≥98%	1884578-00-0	5g	$2820	2026-06-04	Buy
BroadPharm	bp-27986	Boc-Val-Ala-PAB-PNP	1884578-00-0	100MG	$160	2026-05-24	Buy

Product number	Packaging	Price	Buy
CS-0119068	100mg	$156	Buy
CS-0119068	250mg	$257	Buy
CS-0119068	1g	$920	Buy
CS-0119068	5g	$2820	Buy
bp-27986	100MG	$160	Buy

Boc-Val-Ala-PAB-PNP Chemical Properties, Uses, Production

Uses

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

In vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Description

Boc-Val-Ala-PAB-PNP can be used to design cleavable ADC linkers. The Val-Ala, as shown in the ACD Zynlonta, is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Boc-Val-Ala-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

Boc-Val-Ala-PAB-PNP Suppliers

Global Suppliers ( 58)

Supplier	Tel	Email	Country	ProdList	Advantage
Heze Development Zone chuangli Chemical Co., Ltd.	0530-+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	849	55
Shanghai Send Pharmaceutical Technology Co., Ltd.	021-58088081 18317173152	Hailey@shsendpharm.com	China	843	55
Tianjin Chempharmatech Co.,Ltd.	022-66211079 13212288319	sales@chempharmatech.com	China	943	55
Hangzhou J&H Chemical Co., Ltd.	0571-87396432	sales@jhechem.com	China	14905	59
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4229	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.	13632427122;13414494621	chenchao02lzu@126.com	China	137	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58

Supplier	Advantage
Heze Development Zone chuangli Chemical Co., Ltd.	55
Shanghai Send Pharmaceutical Technology Co., Ltd.	55
Tianjin Chempharmatech Co.,Ltd.	55
Hangzhou J&H Chemical Co., Ltd.	59
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Xi'an Confluore Biological Technology Co., Ltd.	58
Hangzhou Peptidego Biotech Co.,Ltd.	58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Latest Price from Boc-Val-Ala-PAB-PNP manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-10	Boc-Val-Ala-PAB-PNP 1884578-00-0				10g	TargetMol Chemicals Inc.
	2025-06-07	Boc-Val-Ala-PAB-PNP 1884578-00-0		1g	>95.00%	1g	Xian confluore Biological Technology Co., Ltd.

Boc-Val-Ala-PAB-PNP
1884578-00-0
$0.00
TargetMol Chemicals Inc.

Boc-Val-Ala-PAB-PNP
1884578-00-0
$0.00
>95.00%
Xian confluore Biological Technology Co., Ltd.

Boc-Val-Ala-PAB-PNP Spectrum

Boc-Val-Ala-PAB-PNP(1884578-00-0)¹HNMR

1884578-00-0 (Boc-Val-Ala-PAB-PNP) Related Search:

Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- (9CI) Mc-Val-Ala-PAB-PNP (Ac)Phe-Lys(Alloc)-PABC-PNP 4-Pentynoyl-Val-Ala-PAB-PNP Carbonic acid, [4-[[(2S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxohexyl]amino]phenyl]methyl 4-nitrophenyl ester

L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-α-glutamyl-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-, 1,1-dimethylethyl ester

1of2

Boc-Val-Ala-PAB-PNP L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- Boc-Val-Ala-PAB-PNP USP/EP/BP 4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate 6-Maleimidohexanoyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)-carbonate [4-[[(2S)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate 1884578-00-0 ADC LINKER Linker