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Mc-Val-Ala-PAB-PNP

Mc-Val-Ala-PAB-PNP Structure
Mc-Val-Ala-PAB-PNP structure
CAS No.
1639939-40-4
Chemical Name:
Mc-Val-Ala-PAB-PNP
Synonyms
4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate;Mc-Val-Ala-PAB-PNP;inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
CBNumber:
CB15479729
Molecular Formula:
C32H37N5O10
Molecular Weight:
651.66
MDL Number:
MFCD32220341
MOL File:
1639939-40-4.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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Mc-Val-Ala-PAB-PNP Properties

Boiling point 946.4±65.0 °C(Predicted)
Density 1.323±0.06 g/cm3(Predicted)
storage temp. -20°C, protect from light, stored under nitrogen
form Solid
pka 13.31±0.70(Predicted)
color White to off-white
InChIKey VMOQJVBAOUFRSX-LGGPFLRQSA-N
SMILES C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

Mc-Val-Ala-PAB-PNP price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PQC93940 Mc-Val-Ala-PAB-PNP 1639939-40-4 25mg $1119.5 2026-06-04 Buy
Biosynth PQC93940 Mc-Val-Ala-PAB-PNP 1639939-40-4 50mg $1557.5 2026-06-04 Buy
Biosynth PQC93940 Mc-Val-Ala-PAB-PNP 1639939-40-4 100mg $2492 2026-06-04 Buy
ChemScene CS-0119076 MC-Val-Ala-PAB-PNP ≥97% 1639939-40-4 50mg $93 2026-06-04 Buy
ChemScene CS-0119076 MC-Val-Ala-PAB-PNP ≥97% 1639939-40-4 100mg $135 2026-06-04 Buy
Product number Packaging Price Buy
PQC93940 25mg $1119.5 Buy
PQC93940 50mg $1557.5 Buy
PQC93940 100mg $2492 Buy
CS-0119076 50mg $93 Buy
CS-0119076 100mg $135 Buy

Mc-Val-Ala-PAB-PNP Chemical Properties, Uses, Production

Uses

Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)[1].

Biological Activity

MC-Val-Ala-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] QINHUAI LAI . Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies[J]. European Journal of Medicinal Chemistry, 2020. DOI:10.1016/j.ejmech.2020.112364.

Mc-Val-Ala-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

Mc-Val-Ala-PAB-PNP Suppliers

Global Suppliers ( 63)
Supplier Tel Email Country ProdList Advantage
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. 13632427122;13414494621 chenchao02lzu@126.com China 137 58
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 1846 58
Tianjin Chempharmatech Co.,Ltd. 022-66211079 13212288319 sales@chempharmatech.com China 944 55
Hygeia (Chengdu) pharmaceutical technique Co., Ltd 028-84502008 13568869383 sales@hygeiapharm.com China 291 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Send Pharmaceutical Technology Co., Ltd. 021-58088081 18317173152 Hailey@shsendpharm.com China 840 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243 3927209986@qq.com China 9999 55
Heze Development Zone chuangli Chemical Co., Ltd. 0530-+86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 849 55
Supplier Advantage
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. 58
Suzhou Highfine Biotech Co., Ltd 58
Tianjin Chempharmatech Co.,Ltd. 55
Hygeia (Chengdu) pharmaceutical technique Co., Ltd 55
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Send Pharmaceutical Technology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Zhengzhou Huiju Chemical Co., Ltd. 55
Heze Development Zone chuangli Chemical Co., Ltd. 55

View Latest Price from Mc-Val-Ala-PAB-PNP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MC-Val-Ala-PAB-PNP pictures 2026-07-15 MC-Val-Ala-PAB-PNP
1639939-40-4
 $40.00 96.71% 10g TargetMol Chemicals Inc.

Mc-Val-Ala-PAB-PNP Spectrum

Mc-Val-Ala-PAB-PNP(1639939-40-4)1HNMR

1639939-40-4 (Mc-Val-Ala-PAB-PNP) Related Search:

Mc-Val-Cit-PABC-PNP Mal-PEG2-VCP-NB Mal-PEG4-Val-Cit-PAB-PNP Mal-amido-PEG2-Val-Cit-PAB-PNP Azido-PEG3-Val-Cit-PAB-PNP
Boc-Val-Cit-PAB-PNP

1of2

Mc-Val-Ala-PAB-PNP L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate 4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate 1639939-40-4 Linker ADC LINKER