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tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate structure

CAS No.: 864771-44-8

Chemical Name:: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

Synonyms: 2-(1-Bo;1-Boc-indazole-5-boronic acid pinacol ester;1-Boc-indazolyl-5-boronic Acid Pinacol Ester;1-Boc-1H-indalzole-5-boronic acid picol ester;1-Boc-1H-indalzole-5-boronic acid pinacol ester;1H-Indazole-5-boronic acid pinacol ester, N1-BOC protected;1-(tert-Butoxycarbonyl)indazolyl-5-boronic Acid Pinacol Ester;1-Boc-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole;1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid pinacol ester;1-Boc-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole

CBNumber:: CB6589574

Molecular Formula:: C18H25BN2O4

Molecular Weight:: 344.21

MDL Number:: MFCD08437629

MOL File:: 864771-44-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:20

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tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate Properties

Melting point	110 °C
Boiling point	461.4±37.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.48±0.30(Predicted)
form	solid
Appearance	White to off-white Solid
InChI	1S/C18H25BN2O4/c1-16(2,3)23-15(22)21-14-9-8-13(10-12(14)11-20-21)19-24-17(4,5)18(6,7)25-19/h8-11H,1-7H3
InChIKey	MMXDKXUKSKMROG-UHFFFAOYSA-N
SMILES	CC1(C)C(C)(C)OB(C2=CC=C3N(C(OC(C)(C)C)=O)N=CC3=C2)O1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

22-26-36/37/39

WGK Germany

WGK 3

HS Code

2933998090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	1
2		0

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CVT00055	1-Boc-5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole, contains isomer	864771-44-8	1g	$379	2026-04-30	Buy
TCI Chemical	B5992	1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole min. 98.0 %	864771-44-8	200MG	$42	2026-04-30	Buy
TCI Chemical	B5992	1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole min. 98.0 %	864771-44-8	1G	$166	2026-04-30	Buy
Usbiological	265860	1-Boc-1H-indazole-5-boronic acid pinacol ester	864771-44-8	50mg	$355	2026-06-03	Buy
Usbiological	265860	1-Boc-1H-indazole-5-boronic acid pinacol ester	864771-44-8	100mg	$460	2026-06-03	Buy

Product number	Packaging	Price	Buy
CVT00055	1g	$379	Buy
B5992	200MG	$42	Buy
B5992	1G	$166	Buy
265860	50mg	$355	Buy
265860	100mg	$460	Buy

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate Chemical Properties, Uses, Production

Synthesis

TERT-BUTYL 5-BROMO-1H-INDAZOLE-1-CARBOXYLATE

651780-02-8

73183-34-3

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE

864771-44-8

Tert-butyl 5-bromo-1H-indazole-1-carboxylate (10.1 mmol) and pinacol ester of bisboronic acid (11.1 mmol) were used as raw materials for the reaction catalyzed by palladium(II) acetate (1.01 mmol) and dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) (1.01 mmol) with the addition of potassium acetate (30.3 mmol) in triethylamine ( 1.5 mL) solution of potassium acetate (30.3 mmol) and 1,4-dioxane (60 mL) as a solvent, and the reaction was carried out at 110 °C overnight. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent: 5% ethyl acetate/petroleum ether) to afford the target product 1-tert-butoxycarbonylindazole-5-boronic acid pinacol ester as a yellow solid in 74% yield.

References

[1] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 69-70
[2] Organic Letters, 2009, vol. 11, # 13, p. 2860 - 2863
[3] Patent: WO2010/59943, 2010, A2. Location in patent: Page/Page column 83; 84
[4] Patent: WO2006/86705, 2006, A1. Location in patent: Page/Page column 89
[5] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 22

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate Preparation Products And Raw materials

Raw materials

tert-Butyl 5-bromo-1H-indazole-1-carboxylate Bis(pinacolato)diboron Potassium Acetate 1,4-Dioxane Triethylamine

Preparation Products

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate Suppliers

Global Suppliers ( 87)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
TCI Europe	320-37350700	sales@tcieurope.eu	Europe	23654	75
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23636	75
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	22497	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Shanghai Ennopharm Co., Ltd.	65
Thermo Fisher Scientific	75
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
TCI Europe	75
TCI AMERICA	75
9ding chemical ( Shanghai) Limited	55
Bide Pharmatech Ltd.	60

View Latest Price from tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-26	TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE 864771-44-8	$6.60	500g	98%	1KG, 50KG, 100KG	Career Henan Chemical Co

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE
864771-44-8
$6.60
98%
Career Henan Chemical Co

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate Spectrum

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE(864771-44-8)¹HNMR

864771-44-8 (tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate) Related Search:

INDAZOLE-5-BORONIC ACID PINACOL ESTER tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate 1-Methylindazol-5-boronic acid 1H-Indazole-5-boronic acid tert-Butyl formate

1-BOC-Indazole-5-boronic acid

1of2

1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid pinacol ester 1-Boc-indazole-5-boronic acid pinacol ester tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)- indazole-1-carboxylic acid tert-butyl ester tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate, 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 1H-Indazole-1-carboxylicacid,5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-,1,1-diMethylethylester tert-butyl 5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate 1-Boc-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 1-Boc-1H-indalzole-5-boronic acid pinacol ester 1-Boc-5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole, contains isomer tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxyla 1H-Indazole-5-boronic acid pinacol ester, N1-BOC protected 1-Boc-1H-indalzole-5-boronic acid picol ester 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole 1-(tert-Butoxycarbonyl)indazolyl-5-boronic Acid Pinacol Ester 1-Boc-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole 1-Boc-indazolyl-5-boronic Acid Pinacol Ester 2-(1-Bo 2-(1-tert-Butoxycarbonyl-5-indazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-carboxylate tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate - [B13702] 864771-44-8 C18H25BN2O4 Indazoles