Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-
![Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Structure](CAS/20200515/GIF/1331754-16-5.gif)
- CAS No.
- 1331754-16-5
- Chemical Name:
- Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-
- Synonyms
- 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-ethanone;Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-
- CBNumber:
- CB65962116
- Molecular Formula:
- C6H8N2O2
- Molecular Weight:
- 140.14
- MDL Number:
- MFCD28675904
- MOL File:
- 1331754-16-5.mol
- MSDS File:
- SDS
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29972 | A6770 ≥98% | 1331754-16-5 | 500μg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 29972 | A6770 ≥98% | 1331754-16-5 | 1mg | $168 | 2026-04-30 | Buy |
| Cayman Chemical | 29972 | A6770 ≥98% | 1331754-16-5 | 5mg | $567 | 2026-04-30 | Buy |
| Cayman Chemical | 29972 | A6770 ≥98% | 1331754-16-5 | 10mg | $1042 | 2026-04-30 | Buy |
| aablocks | AA01LIIY | A6770 ≥98% | 1331754-16-5 | 1mg | $168 | 2026-05-30 | Buy |
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Chemical Properties, Uses, Production
Uses
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].
Biological Activity
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 μM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 μM).
in vivo
A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2]
References
1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
