ChemicalBook >> CAS DataBase List >>(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine structure

CAS No.: 2247953-39-3

Chemical Name:: (R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

Synonyms: AHR antagonist 5;(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

CBNumber:: CB66185181

Molecular Formula:: C25H25ClFN7

Molecular Weight:: 477.97

MDL Number:: MFCD34470337

MOL File:: 2247953-39-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

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(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine Properties

storage temp.	Store at -20°C
form	Solid
color	Yellow to orange
InChIKey	BCXFADDZDWTXMZ-VOPAOICTNA-N
SMILES	N([C@@H]1CCC2NC3=CC=CC=C3C=2C1)C1=NC(C2=CN=CC(F)=C2)=NC2=C(C(C)C)C=NN12.Cl \|&1:1,r\|

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0120848	AHR antagonist 5 98.05%	2247953-39-3	5mg	$487	2026-06-04	Buy
ChemScene	CS-0120848	AHR antagonist 5 98.05%	2247953-39-3	10mg	$785	2026-06-04	Buy
ChemScene	CS-0120848	AHR antagonist 5 98.05%	2247953-39-3	25mg	$1571	2026-06-04	Buy
ChemScene	CS-0120848	AHR antagonist 5 98.05%	2247953-39-3	50mg	$2546	2026-06-04	Buy
ChemScene	CS-0120848	AHR antagonist 5 98.05%	2247953-39-3	100mg	$4117	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0120848	5mg	$487	Buy
CS-0120848	10mg	$785	Buy
CS-0120848	25mg	$1571	Buy
CS-0120848	50mg	$2546	Buy
CS-0120848	100mg	$4117	Buy

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine Chemical Properties, Uses, Production

Uses

AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 μΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1].

Biological Activity

AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 μμ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1]. Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone[1].

in vivo

Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone^[1].

Animal Model:	Balb/c Mice (Mouse Colorectal Cancer Model CT26)^[1]
Dosage:	10 mg/kg (combination with anti-PD-1)
Administration:	P.o.; every day for 3 weeks
Result:	Significantly inhibited tumor growth inhibition.

References

[1]. Alfredo C. Castro, et al. Indole ahr inhibitors and uses thereof. WO2018195397A2.

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine Suppliers

Global Suppliers ( 10)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	959	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Aladdin Scientific		tp@aladdinsci.com	United States	50068	58

Supplier	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58

View Latest Price from (R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	AHR antagonist 5 2247953-39-3	$1520.00-2500.00			10g	TargetMol Chemicals Inc.
	2025-07-17	AHR antagonist 5 2247953-39-3	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

AHR antagonist 5
2247953-39-3
$1520.00-2500.00
TargetMol Chemicals Inc.

AHR antagonist 5
2247953-39-3
$1520.00-2500.00
TargetMol Chemicals Inc.

2247953-39-3 ((R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine) Related Search:

1H-Carbazol-3-amine, N-[2-(5-fluoro-3-pyridinyl)-8-(1-methylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]-2,3,4,9-tetrahydro-, (3R)- NA (R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine Prochloraz α-Naphthoflavone

3-(3-Indolyl)-2-oxopropanoic acid

1of2

(R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine AHR antagonist 5 2247953-39-3