Phospho-STING (Ser365) (D8F4W) Rabbit mAb
- CAS No.
- Chemical Name:
- Phospho-STING (Ser365) (D8F4W) Rabbit mAb
- Synonyms
- Phospho-STING (Ser365) (D8F4W) Rabbit mAb
- CBNumber:
- CB66277378
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Phospho-STING (Ser365) (D8F4W) Rabbit mAb Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Mouse
Background
Stimulator of interferon genes is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA. STING is a ubiquitously expressed protein found predominantly in the ER. The enzyme cGAMP synthase produces the second messenger cyclic-GMP-AMP in response to cytoplasmic DNA. cGAMP binds and activates STING. In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation. Following activation, STING translocates with TBK1 to perinuclear endosomes. The TBK1 kinase phosphorylates and activates interferon regulatory factors and NF-κB, which leads to the induction of type I interferon and other immune response genes.Following binding of cyclic dinucleotides, STING is phosphorylated by TBK1 at Ser366, leading to IRF-3 activation and type I interferon upregulation.
References
[1] Ishikawa, H. and Barber, G.N. (2008) Nature 455, 674-8.
[2] Zhong, B. et al. (2008) Immunity 29, 538-50.
[3] Sun, L. et al. (2013) Science 339, 786-91.
[4] Wu, J. et al. (2013) Science 339, 826-30.
[5] Zhang, Z. et al. (2011) Nat Immunol 12, 959-65.
[6] Unterholzner, L. et al. (2010) Nat Immunol 11, 997-1004.
[7] Ishikawa, H. et al. (2009) Nature 461, 788-92.
[8] Liu, S. et al. (2015) Science 347, aaa2630.
Phospho-STING (Ser365) (D8F4W) Rabbit mAb Preparation Products And Raw materials
Raw materials
Preparation Products
Phospho-STING (Ser365) (D8F4W) Rabbit mAb Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
