4-(tert-Butoxycarbonyl)benzoic acid
- CAS No.
- 20576-82-3
- Chemical Name:
- 4-(tert-Butoxycarbonyl)benzoic acid
- Synonyms
- tert-Butyl terephthalate;mono-(tert-Butyl) terephthalate;tert-Butyl hydrogen terephthalate;4-(tert-Butoxycarbonyl)benzoic acid;TEREPHALIC ACID MONO TERT-BUTYL ESTER;1-(1,1-Dimethylethyl) 1,4-benzenedicarboxylate;4-[(2-methylpropan-2-yl)oxycarbonyl]benzoic Acid;4-[(2-methylpropan-2-yl)oxy-oxomethyl]benzoic acid;1,4-Benzenedicarboxylic acid, 1-(1,1-dimethylethyl) ester;4-(tert-Butoxycarbonyl)benzoic acid, tert-Butyl 4-carboxybenzoate
- CBNumber:
- CB6722676
- Molecular Formula:
- C12H14O4
- Molecular Weight:
- 222.24
- MDL Number:
- MFCD04037901
- MOL File:
- 20576-82-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 209-212(dec.) |
|---|---|
| Boiling point | 351.8±25.0 °C(Predicted) |
| Density | 1.173±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly). Methanol (Slightly) |
| pka | 3.76±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2918300090 |
4-(tert-Butoxycarbonyl)benzoic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B809505-1G | Mono-tert-Butyl Terephthalate | 20576-82-3 | 1g | $199 | 2026-06-03 | Buy |
| TRC | TRC-B809505-10G | Mono-tert-Butyl Terephthalate | 20576-82-3 | 10g | $921 | 2026-06-03 | Buy |
| Apolloscientific | OR7829 | mono-(tert-Butyl) terephthalate 98% | 20576-82-3 | 5g | $92 | 2026-06-04 | Buy |
| Apolloscientific | OR7829 | mono-(tert-Butyl) terephthalate 98% | 20576-82-3 | 25g | $384 | 2026-06-04 | Buy |
| Apolloscientific | OR7829 | mono-(tert-Butyl) terephthalate 98% | 20576-82-3 | 100g | $1514 | 2026-06-04 | Buy |
4-(tert-Butoxycarbonyl)benzoic acid Chemical Properties, Uses, Production
Uses
Mono-tert-Butyl Terephthalate, is used in the synthesis of pyrrolidinone analogs acting as potential 20S proteasome inhibitors.
Synthesis
28313-42-0
20576-82-3
The general procedure for the synthesis of 4-(tert-butoxycarbonyl)benzoic acid from di-tert-butyl terephthalate was as follows: 6.1 g (0.022 mol) of di-tert-butyl terephthalate was suspended in 30 mL of tert-butanol, and 22 mL (0.022 mol) of 1N KOH solution was slowly added. The reaction mixture was heated to 60°C and maintained at this temperature for 7-8 hours. After completion of the reaction, the mixture was cooled, diluted with water and extracted three times with ethyl acetate. After combining the organic phases, the aqueous phase was acidified to acidity with dilute hydrochloric acid and the product was again extracted with ethyl acetate. All ethyl acetate extracts were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to give 4-(tert-butoxycarbonyl)benzoic acid (mono-tert-butyl terephthalate) as a white solid with a yield of 4.7 g, 96% yield, and a melting point of 100-102°C. The product was extracted with dilute hydrochloric acid.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 4, p. 641 - 662
[2] Patent: US5221665, 1993, A
[3] Patent: US5232928, 1993, A
[4] Patent: EP369391, 1991, A3
[5] Patent: EP369391, 1990, A2
4-(tert-Butoxycarbonyl)benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3827 | 58 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
View Latest Price from 4-(tert-Butoxycarbonyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-[(2-methylpropan-2-yl)oxycarbonyl]benzoicacid pictures](/ProductImageEN/2022-01/Small/3cb1ebca-80cd-48e7-92bd-e1f095de5b31.jpeg) |
2022-01-15 | 4-[(2-methylpropan-2-yl)oxycarbonyl]benzoicacid
20576-82-3
|
1KG | 98.6% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-01-01 | 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID
20576-82-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-[(2-methylpropan-2-yl)oxycarbonyl]benzoicacid
20576-82-3
- $0.00
- 98.6%
- Honest Joy Holdings Limited
-
- 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID
20576-82-3
- $1.00
- 99%
- Career Henan Chemical Co
