(+)-COSTUNOLIDE
- CAS No.
- 591207-53-3
- Chemical Name:
- (+)-COSTUNOLIDE
- Synonyms
- (E/Z)-LAQ824;COSTUS LACTONE
- CBNumber:
- CB6745769
- Molecular Formula:
- C15H20O2
- Molecular Weight:
- 232.32
- MDL Number:
- MFCD00210486
- MOL File:
- Mol file
(+)-COSTUNOLIDE Chemical Properties, Uses, Production
Uses
(E/Z)-Dacinostat ((E/Z)-NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z)-Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.
References
[1] Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance
(+)-COSTUNOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-COSTUNOLIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Zhanshu Chemical Technology Co., Ltd | +86-21-58589556 | China | 413 | 55 | |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | 0531-68652808 18953170293 | sales@sdzschem.com | China | 2921 | 58 |
| Shandong Zhishang New Material Co., Ltd. | +8617653113209 | sales002@sdzschem.com | China | 2921 | 58 |
| ShanDong Look Chemical Co.,Ltd. | 17653113209 13065062079 | sales01@sdlookchemical.com | China | 2921 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
