Ethynodiol diacetate
- CAS No.
- 297-76-7
- Chemical Name:
- Ethynodiol diacetate
- Synonyms
- Ethynodiol;Femulen;CB-8080;ovulen50;SC 11800;8080c.b.;Etynodiol;Luteonorm;Metrodiol;Ovulen 50
- CBNumber:
- CB6749404
- Molecular Formula:
- C24H32O4
- Molecular Weight:
- 384.51
- MDL Number:
- MFCD00083326
- MOL File:
- 297-76-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~126-127° |
|---|---|
| alpha | D -72.5° (chloroform) |
| Boiling point | 431.17°C (rough estimate) |
| Density | 1.0474 (rough estimate) |
| refractive index | 1.4860 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| color | White |
| Water Solubility | 1.4mg/L(25 ºC) |
| CAS DataBase Reference | 297-76-7(CAS DataBase Reference) |
| FDA UNII | 62H10A1236 |
| ATC code | G03DC06 |
| NIST Chemistry Reference | Ethynodiol diacetate(297-76-7) |
| EPA Substance Registry System | Ethynodiol diacetate (297-76-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H351 | |||||||||
| Precautionary statements | P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC8963000 | |||||||||
| HS Code | 2937230000 | |||||||||
| NFPA 704 |
|
Ethynodiol diacetate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E7263 | Ethynodiol diacetate | 297-76-7 | 500mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP1131 | Ethynodiol diacetate British Pharmacopoeia (BP) Reference Standard | 297-76-7 | 100 mg | $258 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1268003 | Ethynodiol diacetate United States Pharmacopeia (USP) Reference Standard | 297-76-7 | 200mg | $420 | 2026-04-30 | Buy |
| TCI Chemical | E1315 | Ethynodiol Diacetate | 297-76-7 | 1G | $108 | 2026-04-30 | Buy |
| TCI Chemical | E1315 | Ethynodiol Diacetate | 297-76-7 | 5G | $372 | 2026-04-30 | Buy |
Ethynodiol diacetate Chemical Properties,Uses,Production
Description
Ethynodiol diacetate is a synthetic progestogen. It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 μg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits. Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Originator
Lutometrodiol,Searle,France,1965
Uses
anticonvulsant
Uses
Ethynodiol Diacetate is used as a hormonal contraceptive, birth control.
Definition
ChEBI: Ethynodiol diacetate is a steroid ester and a terminal acetylenic compound. It has a role as an estrogen receptor modulator, a contraceptive drug and a synthetic oral contraceptive. It is functionally related to an ethynodiol.
Manufacturing Process
A mixture of 30 parts of 17α-ethynyl-19-norandrost-4-ene-3β,17β-diol, 360 parts of dry pyridine, and 111 parts of acetic anhydride, under nitrogen, is stirred and heated at the reflux temperature for about 5 hours. This reaction mixture is cooled, then poured into approximately 3,500 parts of cold water and the resulting aqueous mixture is stirred at room temperature for about 0.5 hour. The precipitate which forms is collected by filtration, then is washed on the filter with water and dried in air. This solid material is extracted into ether, and the ether solution is washed successively with 10% aqueous
Therapeutic Function
Progestin; Oral contraceptive ingredient
General Description
Ethynodiol diacetate, 19-norpregn-4-en-20-yne-3β,17α-diol diacetate, is a prodrug ofnorethindrone. A combination of hydrolysis of both estersand oxidation of the C3 alcohol to the ketone is necessary toprovide the fully active progestin.
Safety Profile
Suspected carcinogen. Human reproductive effects by ingestion: menstrual cycle changes. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
References
[1] J M AITKEN J B A E Armstrong. Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and-or progestogen replacement therapy in its prevention.[J]. Journal of Endocrinology, 1972, 55 1: 79-87. DOI: 10.1677/joe.0.0550079
[2] M SUZUKI K T M Hiroi. Effects of ethynodiol diacetate (SC 11800) on the pregnancy and mating behavior in female rats.[J]. Tohoku Journal of Experimental Medicine, 1972, 107 4: 317-322. DOI: 10.1620/tjem.107.317
Ethynodiol diacetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
View Lastest Price from Ethynodiol diacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Ethynodiol diacetate
297-76-7
|
$29.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Ethynodiol diacetate
297-76-7
|
$29.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-27 | Ethynodiol diacetate
297-76-7
|
$35.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- Ethynodiol diacetate
297-76-7
- $29.00
- 99.89%
- TargetMol Chemicals Inc.
-
- Ethynodiol diacetate
297-76-7
- $29.00
- 99.89%
- TargetMol Chemicals Inc.
-
- Ethynodiol diacetate
297-76-7
- $35.00
- 99.89%
- TargetMol Chemicals Inc.
