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ChemicalBook >> CAS DataBase List >>3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Structure
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER structure
CAS No.
106263-53-0
Chemical Name:
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
Synonyms
ETHYL (4-TRIFLUOROMETHYLBENZOYL)ACETATE;Ethyl 2-[4-(TrifluoroMethyl)benzoyl]acetate;Ethyl β-oxo-4-(trifluoromethyl)benzenepropanoate;Ethyl 3-(4-trifluoromethylphenyl)-3-oxopropionate;ETHYL 3-(4-TRIFLUOROMETHYL-PHENYL)-3-OXOPROPANOATE;Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoat;ETHYL Β-OXO-4-(TRIFLUOROMETHYL)-BENZENEPROPANOIC ACID;ethyl β-oxo-4-(trifluoromethyl)-benzenepropanoic acid;3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER;3-Oxo-3-(4-trifluoromethylphenyl)propanoic acid ethyl ester
CBNumber:
CB6763392
Molecular Formula:
C12H11F3O3
Molecular Weight:
260.21
MDL Number:
MFCD03424818
MOL File:
106263-53-0.mol
MSDS File:
SDS
Last updated:2026-05-28 04:11:48
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3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Properties

Boiling point 248-249 °C(lit.)
Density 1.270 g/mL at 25 °C(lit.)
refractive index n20/D 1.4880(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
form liquid
pka 9.09±0.25(Predicted)
color Light yellow
InChI 1S/C12H11F3O3/c1-2-18-11(17)7-10(16)8-3-5-9(6-4-8)12(13,14)15/h3-6H,2,7H2,1H3
InChIKey HVHVSJPSNQIPEM-UHFFFAOYSA-N
SMILES CCOC(=O)CC(=O)c1ccc(cc1)C(F)(F)F
CAS DataBase Reference 106263-53-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
PPE Eyeshields, Gloves
Hazard Codes  F
WGK Germany  3
HS Code  2918300090
Storage Class 10 - Combustible liquids

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 559059 Ethyl (4-trifluoromethylbenzoyl)acetate 106263-53-0 5g $149 2023-06-20 Buy
Apolloscientific PC1854 Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate 97% 106263-53-0 1g $21 2026-06-04 Buy
Apolloscientific PC1854 Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate 97% 106263-53-0 5g $49 2026-06-04 Buy
Apolloscientific PC1854 Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate 97% 106263-53-0 25g $203 2026-06-04 Buy
Apolloscientific PC1854 Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate 97% 106263-53-0 100g $797 2026-06-04 Buy
Product number Packaging Price Buy
559059 5g $149 Buy
PC1854 1g $21 Buy
PC1854 5g $49 Buy
PC1854 25g $203 Buy
PC1854 100g $797 Buy

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Chemical Properties,Uses,Production

Uses

Reactant for:

  • In-catalyzed cycloisomerization
  • Chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water
  • Guanidine-catalyzed enantioselective Michael reactions
  • Transesterification reactions
  • Intermolecular coupling reactions

Synthesis

Cobalt, octacarbonyldi-, (Co-Co)

15226-74-1

4-Bromobenzotrifluoride

402-43-7

Ethyl potassium malonate

6148-64-7

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER

106263-53-0

To a stirred 30 mL microwave vial was added a solution of aryl or heteroaryl halides (Br, I) (0.5 mmol) and monoethyl malonate potassium salt (0.75 mmol) in THF (10 mL). Pd(OAc)2 (5 mol%), Xantphos (5 mol%), MgCl2 (0.75 mmol), Et3N (0.75 mmol), imidazole (1 mmol), and Co2(CO)8 (0.15 mmol) were then added sequentially. The vials were immediately sealed and subjected to microwave irradiation at 90 °C for 30 min. After completion of the reaction, the mixture was concentrated and diluted with ethyl acetate and water. The organic layer (ethyl acetate layer) was separated, dried over anhydrous sodium sulfate and then concentrated. The crude product was purified by column chromatography to afford the target compound ethyl 4-trifluoromethylbenzoylacetate.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 25, p. 3525 - 3528

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Cobalt, octacarbonyldi-, (Co-Co) 4-Bromobenzotrifluoride Ethyl potassium malonate Tetrahydrofuran Imidazole
4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene Magnesium chloride Palladium (II) Acetate Triethylamine

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Preparation Products

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Suppliers

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Sci General Material & Chemical Ltd 021-58388037;21-58388037 13472507714 35177634@qq.com;1589045147@qq.com China 795 55
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 695 58
Tianjin Derchemist Science & Technology Co., Ltd. 22-58627059 13920586291 zdcomcon@126.com China 4094 50
Shanghai Synthfine Chemical Co.,Ltd 15921303235 sales@synthfine.com China 999 58
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
Sci General Material & Chemical Ltd 55
Heterochem 58
Tianjin Derchemist Science & Technology Co., Ltd. 50
Shanghai Synthfine Chemical Co.,Ltd 58
Shanghai civi chemical technology co.,Ltd 52
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65

View Lastest Price from 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER pictures 2020-01-08 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
106263-53-0
 $3.00 200KG 98% 20000KG Career Henan Chemical Co

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Spectrum

3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER(106263-53-0)1HNMR3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER(106263-53-0)IR

106263-53-0(3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER)Related Search:

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3-OXO-3-P-TOLYL-PROPIONIC ACID ETHYL ESTER 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER ETHYL 2-BROMO-3-(4-TRIFLUOROMETHYLPHENYL)-3-OXO-PROPANOATE

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ETHYL (4-TRIFLUOROMETHYLBENZOYL)ACETATE ETHYL 3-(4-TRIFLUOROMETHYL-PHENYL)-3-OXOPROPANOATE Ethyl 2-[4-(TrifluoroMethyl)benzoyl]acetate beta-Oxo-4-(trifluoromethyl)benzenepropanoic acid ethyl ester Ethyl 3-(4-trifluoromethylphenyl)-3-oxopropionate 3-Oxo-3-(4-trifluoromethylphenyl)propanoic acid ethyl ester Benzenepropanoic acid, β-oxo-4-(trifluoromethyl)-, ethyl ester ethyl β-oxo-4-(trifluoromethyl)-benzenepropanoic acid 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER ? Benzenepropanoic acid, β-oxo-4-(trifluoromethyl)-, ethyl ester ETHYL Β-OXO-4-(TRIFLUOROMETHYL)-BENZENEPROPANOIC ACID Ethyl β-oxo-4-(trifluoromethyl)benzenepropanoate Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoat 106263-53-0 Organic Building Blocks Esters C12 to C63 Carbonyl Compounds Building Blocks C12 to C63 Carbonyl Compounds Esters