N-(3-HYDROXYPROPYL)PHTHALIMIDE
- CAS No.
- 883-44-3
- Chemical Name:
- N-(3-HYDROXYPROPYL)PHTHALIMIDE
- Synonyms
- 2-(3-Hydroxypropyl)isoindoline-1,3-dione;AURORA 4786;2-(3-Hydroxypropyl);3-PHTHALIMIDO-1-PROPANOL;N-(3-HYDROXYPROPYL)PHTHALIMIDE;N-(3-Hydroxypropyl)phthaliMide 95%;N-(3-Hydroxypropyl)phthalimide,99%;N-(3-Hydroxypropyl) phthalimide-98%;N-(3-HYDROXYPROPYL)PHTHALIMIDE, 95+%;N-(3-Hydroxypropyl)phthalimide
- CBNumber:
- CB6767017
- Molecular Formula:
- C11H11NO3
- Molecular Weight:
- 205.21
- MDL Number:
- MFCD00023097
- MOL File:
- 883-44-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 74-76 °C (lit.) |
|---|---|
| Boiling point | 376.5±25.0 °C(Predicted) |
| Density | 1.331±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 14.88±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| BRN | 158489 |
| InChI | 1S/C11H11NO3/c13-7-3-6-12-10(14)8-4-1-2-5-9(8)11(12)15/h1-2,4-5,13H,3,6-7H2 |
| InChIKey | BSMILTTURCQDGJ-UHFFFAOYSA-N |
| SMILES | OCCCN1C(=O)c2ccccc2C1=O |
| CAS DataBase Reference | 883-44-3(CAS DataBase Reference) |
| FDA UNII | X2TMC7E8YH |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H302-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29251900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
N-(3-HYDROXYPROPYL)PHTHALIMIDE price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 103063 | N-(3-Hydroxypropyl)phthalimide 95% | 883-44-3 | 25g | $67.3 | 2023-06-20 | Buy |
| ChemScene | CS-W023194 | 2-(3-Hydroxypropyl)isoindoline-1,3-dione ≥98% | 883-44-3 | 25g | $24 | 2026-06-04 | Buy |
| ChemScene | CS-W023194 | 2-(3-Hydroxypropyl)isoindoline-1,3-dione ≥98% | 883-44-3 | 100g | $92 | 2026-06-04 | Buy |
| ChemScene | CS-W023194 | 2-(3-Hydroxypropyl)isoindoline-1,3-dione ≥98% | 883-44-3 | 500g | $497 | 2026-06-04 | Buy |
| Matrix Scientific | 206726 | 2-(3-Hydroxypropyl)isoindoline-1,3-dione | 883-44-3 | 1.00g | $193 | 2026-05-18 | Buy |
N-(3-HYDROXYPROPYL)PHTHALIMIDE Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
N-(3-Hydroxypropyl)phthalimide was used as standard in the synthesis of phthalimide derivatives at high-temperature, high-pressure and H2O/EtOH mixtures as the solvent. It may be used in the synthesis of hydrophilic phosphorylcholine-containing polymer, poly-2-[3-(methacryloylamino)propylammonio] ethyl 3-aminopropyl phosphate.
Definition
ChEBI: N-(3-Hydroxypropyl)phthalimide is a member of phthalimides.
General Description
N-(3-Hydroxypropyl)phthalimide is ω-Hydroxyalkylphthalimide and is prepared by mixing phthalic anhydride and propanolamine and by heating at 160-180 °C for 4 hours.
Synthesis
85-44-9
156-87-6
883-44-3
3-Amino-1-propanol (10.0 g, 133.1 mmol) was dissolved in anhydrous toluene (100 mL). Phthalic anhydride (19.7 g, 133.1 mmol) was added to the solution under argon protection. The reaction mixture was heated with stirring at 125 °C for 6.5 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by vacuum evaporation to afford the white powdery product 2-(3-hydroxypropyl)isodihydroindole-1,3-dione (31.7 g, quantitative yield), which could be used in subsequent steps without further purification.
References
[1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 644 - 647
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 32, p. 6094 - 6104
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 16, p. 5903 - 5914
[4] Chemistry - A European Journal, 2014, vol. 20, # 44, p. 14256 - 14260
[5] Chemical Papers, 2017, vol. 71, # 11, p. 2293 - 2299
N-(3-HYDROXYPROPYL)PHTHALIMIDE Preparation Products And Raw materials
N-(3-HYDROXYPROPYL)PHTHALIMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Yongsheng Pharmaceutical Technology Co., Ltd | 3307 18017383231 | 983544897@qq.com | China | 941 | 58 |
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