Trimetrexate glucuronate
- CAS No.
- 82952-64-5
- Chemical Name:
- Trimetrexate glucuronate
- Synonyms
- CI 898 dihydrochloride;CI 898 TRIHYDROCHLORIDE;Trimetrexate glucuronate;CI 898 D-Glucuronic Acid Salt (Trimetrexate D-Glucuronic Acid Salt);5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate;5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride
- CBNumber:
- CB6850867
- Molecular Formula:
- C19H23N5O3.C6H10O7
- Molecular Weight:
- 563.56
- MDL Number:
- MFCD01725300
- MOL File:
- 82952-64-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | Off-white to light yellow |
| NCI Dictionary of Cancer Terms | trimetrexate glucuronate |
| FDA UNII | L137U4A79K |
| NCI Drug Dictionary | trimetrexate glucuronate |
| Proposition 65 List | Trimetrexate Glucuronate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
Trimetrexate glucuronate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 444532 | Trimetrexate Glucuronate (CI-898 Glucuronate) | 82952-64-5 | 5mg | $656 | 2026-06-03 | Buy |
| Usbiological | 444532 | Trimetrexate Glucuronate (CI-898 Glucuronate) | 82952-64-5 | 10mg | $1034 | 2026-06-03 | Buy |
| ChemScene | CS-0027819 | Trimetrexate glucuronate 98.09% | 82952-64-5 | 5mg | $286 | 2026-06-04 | Buy |
| ChemScene | CS-0027819 | Trimetrexate glucuronate 98.09% | 82952-64-5 | 10mg | $520 | 2026-06-04 | Buy |
| ChemScene | CS-0027819 | Trimetrexate glucuronate 98.09% | 82952-64-5 | 50mg | $1820 | 2026-06-04 | Buy |
Trimetrexate glucuronate Chemical Properties,Uses,Production
Description
Trimetrexate glucuronate is a nonclassical antifolate introduced in the U.S.A. and Canada as second-line therapy for the treatment of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis in AIDS patients who are refractory or intolerant to co-trimoxazole therapy. Trimetrexate glucuronate is reportedly to be in clinical trials for the treatment of several types of cancer including colorectal, gastric, pancreas, prostate, bladder, lung, breast, head, and neck cancers. It is also in early clinical trials for topical use in treating psoriasis and as an oral drug to treat rheumatoid arthritis. The mechanism of action of trimetrexate glucuronate is via inhibition of the enzyme dihydrofolate reductase which mediates the reduction of dihydrofolate to tetrahydrofolic acid and results in disruption of DNA, RNA and protein synthesis, with consequent cell death. Due to its toxicity to bone marrow and the GI tract, trimetrexate glucuronate must be concurrently administered with leucovorin as a rescue agent.
Originator
Warner-Lambert (U.S.A.)
Uses
Antineoplastic.
Uses
CI 898 Glucuronate is a dihydrofolate reductase (DHFR) inhibitor.
Manufacturing Process
A mixture of 2,4-diamino-5-methyl-6-[(3,4,5- trimethoxyanilino)methyl]quinazoline (1.0 g) and glucuronic acid (0.7 g) in methanol (65 ml) is heated to dissolve the solid. The solution is cooled to 10°C and filtered to remove a small amount of solid. The filtrate is heated to reflux and ethyl acetate is added to the cloud point. The warm solution is filtered then slowly cooled. The solid that forms is collected, washed first with ethylacetate, then with ether and dried in vacuo at 60°C to give the 4- diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline D_x0002_glucuronate as a yellow powder with no definite melting point.
brand name
Neutrexin (MedImmune).
Therapeutic Function
Antineoplastic
Biological Activity
Potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that displays antineoplastic and antiprotozoal properties. Inhibits protozoal, bacterial and human DHFR with IC 50 values of 1.4, 6.1 and 3.2 nM respectively. Affects G 1 /S phase cell cycle progression.
Trimetrexate glucuronate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15934 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Lastest Price from Trimetrexate glucuronate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Trimetrexate glucuronate
82952-64-5
|
10g | TargetMol Chemicals Inc. |
-
- Trimetrexate glucuronate
82952-64-5
- TargetMol Chemicals Inc.
82952-64-5(Trimetrexate glucuronate)Related Search:
1of4
