Procaine hydrochloride
- CAS No.
- 51-05-8
- Chemical Name:
- Procaine hydrochloride
- Synonyms
- PROCAINE HCL;NOVOCAINE HYDROCHLORIDE;PROCAIN HYDROCHLORIDE;anestil;syncaine;juvocaine;bernocaine;chlorocaine;diethylaminoethanol4-aminobenzoatehydrochloride;cetain
- CBNumber:
- CB6853707
- Molecular Formula:
- C13H21ClN2O2
- Molecular Weight:
- 272.77
- MDL Number:
- MFCD00007893
- MOL File:
- 51-05-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-156 °C(lit.) |
|---|---|
| Boiling point | 195-196°C 17mm |
| Density | 1.1761 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| Flash point | 195-196°C/17mm |
| storage temp. | 2-8°C |
| solubility |
DMF: 20 mg/ml DMSO: 14 mg/ml Ethanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml |
| form | Crystals or Crystalline Powder |
| color | Colorless to white |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 14,7757 |
| BRN | 3917802 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H |
| InChIKey | HCBIBCJNVBAKAB-UHFFFAOYSA-N |
| SMILES | Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| LogP | 2.364 (est) |
| CAS DataBase Reference | 51-05-8(CAS DataBase Reference) |
| FDA UNII | 95URV01IDQ |
| EPA Substance Registry System | Procaine hydrochloride (51-05-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P280-P301+P310-P302+P352 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-43-36/37/38-23/24/25 | |||||||||
| Safety Statements | 36/37/39-45-37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG2275000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Skin Sens. 1 |
|||||||||
| Toxicity | LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Procaine hydrochloride price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P9879 | Procaine hydrochloride ≥97% | 51-05-8 | 50G | $36.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | P9879 | Procaine hydrochloride ≥97% | 51-05-8 | 100G | $61.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1161 | Procaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 51-05-8 | 1G | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | P9879 | Procaine hydrochloride ≥97% | 51-05-8 | 250G | $132 | 2026-04-30 | Buy |
| Sigma-Aldrich | P3100000 | Procaine hydrochloride European Pharmacopoeia (EP) Reference Standard | 51-05-8 | 100 mg | $182 | 2026-04-30 | Buy |
Procaine hydrochloride Chemical Properties,Uses,Production
Description
Procaine hydrochloride, also called Novocain, or Novocaine, a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The above information is edited by the chemicalbook of Kui Xiongfeng.
Chemical Properties
Procaine hydrochloride is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol and almost insoluble in ether; solutions acid to litmus. Because the ester bond in the structure can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. Procaine hydrochloride has aromatic primary amino groups in its structure, which can be easily oxidized and discolored. pH, temperature, ultraviolet light, oxygen and metal ions can accelerate the oxidation and discoloration.
Uses
Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
Application
Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay. It is a sodium channel blocker and DNA methylation inhibitor.
Definition
ChEBI: Procaine hydrochloride is an organic molecular entity.
brand name
Novocain (Hospira).
General Description
Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Hazard
Toxic by ingestion.
Biochem/physiol Actions
Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine. It is also useful as a painkiller to treat pain, associated with joints and tendons.
Contact allergens
Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: acute renal fdure. May have human reproductive effects. See also ESTERS. When heated to decomposition it emits very toxic fumes of HCl and NO,. Used as a local anesthetic.
Synthesis
The synthesis method of procaine hydrochloride is to carry out esterification reaction between p-nitrobenzoic acid and diethylaminoethanol, add Ni powder and other catalysts, and then introduce hydrogen to carry out hydrogenation reaction; this synthesis method has the characteristics of high yield, simple operation and environmental protection.
Purification Methods
Novocain is recrystallised from aqueous EtOH. It is soluble at 25o in H2O (86.3%), EtOH (2.6%) and Me2CO (1%), it is slightly soluble in CHCl3, but is almost insoluble in Et2O. The anhydrous free base is recrystallised from ligroin or Et2O and has m 61o. [Einhorn Justus Liebigs Ann Chem 371 125 1909, IR: Szymanski & Panzica J Amer Pharm Assoc 47 443 1958, Beilstein 14 IV 1138.]
Mode of action
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Precautions
Procaine hydrochloride is used for infiltration, nerve block, peridural and spinal anest sthesia. It is considered a fairly safe drug if suitable precautions are observed. However, as with any anesthetic， idiosyncrasy may be encountered. Slow administration and avoidance of accidental intravenous injection are advisable. In local administration, if increased sensitivity to procaine is suspected, as in patients with cardiac disease or endocrine disorders (such as hyperthyroidism), an initial small dose to test tolerance is recommended. (Physicians' Desk Reference, 35th ed, p. 695)
References
[1] SIDNEY EPSTEIN D.D.S. Neal W C D D S. The clinical effectiveness of certain local anesthetics in dental procedures[J]. Oral Surgery, Oral Medicine, Oral Pathology, 1959, 12 1: Pages 93-103. DOI: 10.1016/0030-4220(59)90086-6
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
Procaine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou josenchem Pharmaceutical Chemical Material Co.,Ltd. | 519-519-85286950 13338194135 | info@josenchem.com | China | 73 | 58 |
| Changzhou Sunlight Farmacéutica.S.L. | 0519-83138357 ， 13706121722 15906111278 | 810308@sunlightchem.com | China | 34 | 60 |
| Guangzhou Shunyi Pharmaceutical Chemical Co., Ltd. | 15360832999;13560093877 | jasontim@shuntongchem.cn | China | 41 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd. | 0519-85195575 15861192208;15861192208;13685253038 | 850305@sunkechem.com | China | 72 | 69 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
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View Lastest Price from Procaine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | Procaine hydrochloride
51-05-8
|
$1.00 | 1g | 99% | 10 tons | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-12 | Procaine hydrochloride
51-05-8
|
$1.00 | 300g | 99.8% | 20 TONS | .GZ HONESTCHEM CO.,LTD | |
 |
2026-09-11 | Procaine hydrochloride
51-05-8
|
1KG | 99%-101%,USP36 | 50kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Procaine hydrochloride
51-05-8
- $1.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Procaine hydrochloride
51-05-8
- $1.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- Procaine hydrochloride
51-05-8
- 99%-101%,USP36
- WUHAN FORTUNA CHEMICAL CO., LTD
