L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
![L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Structure](CAS/20210305/GIF/2055024-63-8.gif)
- CAS No.
- 2055024-63-8
- Chemical Name:
- L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
- Synonyms
- NH2-PEG1-Val-Cit-PAB-OH;L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
- CBNumber:
- CB68620613
- Molecular Formula:
- C23H38N6O6
- Molecular Weight:
- 494.58
- MDL Number:
- MOL File:
- 2055024-63-8.mol
L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | bp-23208 | NH2-PEG1-Val-Cit-PAB-OH | 2055024-63-8 | 50MG | $380 | 2026-05-24 | Buy |
| BroadPharm | bp-23208 | NH2-PEG1-Val-Cit-PAB-OH | 2055024-63-8 | 100MG | $680 | 2026-05-24 | Buy |
| BroadPharm | bp-23208 | NH2-PEG1-Val-Cit-PAB-OH | 2055024-63-8 | 250MG | $1100 | 2026-05-24 | Buy |
| BroadPharm | bp-23208 | NH2-PEG1-Val-Cit-PAB-OH | 2055024-63-8 | 500MG | $1650 | 2026-05-24 | Buy |
| aablocks | AA019E3I | NH2-PEG1-Val-Cit-PAB-OH >96% | 2055024-63-8 | 100mg | $762 | 2026-05-29 | Buy |
L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Chemical Properties, Uses, Production
Uses
NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Ornithinamide, N-[3-(2-aminoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Affinity（Wuhan）Ltd. | 15841022315 | sales@affinitytech.cn | China | 2980 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | 18918657159 | sales-Aigen@lianhetech.com | China | 2998 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38904 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| Shanghai Xinketai Biotechnology Co., Ltd | 18043446684 | 3622784229@qq.com | China | 1168 | 58 |
| Biomatrik Inc. | 0573-82623377 18967387295 | sales@biomatrik.cn | China | 1000 | 58 |
| Affinity Linkers Ltd. | 15841022315 15841022315 | sales@affinitytech.cn | China | 7039 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
