DBCO-NHS Ester
- CAS No.
- 1353016-71-3
- Chemical Name:
- DBCO-NHS Ester
- Synonyms
- DBCO-NHS;N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS ester;CAS_1353016-71-3;DBCO-CH2CH2COONHS;Dbco-nhs 98% 100mg;DBCO-NHS Ester (CCT-A133);DBCO-NHS ester, 10 mM in DMSO;DBCO-NHS Ester, ≥98% (CCT-1491);DBCO-NHS ester (DBCO NHS ester)
- CBNumber:
- CB23146567
- Molecular Formula:
- C23H18N2O5
- Molecular Weight:
- 402.4
- MDL Number:
- MFCD24386367
- MOL File:
- 1353016-71-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 670.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Storage temp. -20°C |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | -0.23±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Appearance | White solid |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2 |
| InChIKey | XCEBOJWFQSQZKR-UHFFFAOYSA-N |
| SMILES | C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)ON1C(CCC1=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29339900 |
DBCO-NHS Ester price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 25mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 50mg | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 100mg | $283 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 250mg | $545 | 2026-04-30 | Buy |
| TRC | TRC-D194965-50MG | DBCO-NHS Ester | 1353016-71-3 | 50mg | $371 | 2026-06-03 | Buy |
DBCO-NHS Ester Chemical Properties, Uses, Production
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
Uses
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
IC 50
Cleavable Linker
DBCO-NHS Ester Preparation Products And Raw materials
Raw materials
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Preparation Products
DBCO-NHS Ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1978 | 58 |
| Shanghai Send Pharmaceutical Technology Co., Ltd. | +86-021-50266790 18317173152 | sale@shsendpharm.com | China | 195 | 50 |
| Shanghai Huasige Pharmaceutical Technology Co., LTD | 13611612777 | 3627377363@qq.com | China | 4757 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | 133-31922809 19372841038 | lixing@pharmahuici.com | China | 853 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
| Chemyouth Life Science（Suzhou）Co.,Ltd | 18605123100 | kaiyuezhang@chemyouth.com | China | 153 | 58 |
| Shijiazhuang Qihengyun Biotechnology Co., Ltd | 13582612079 | 44776198@qq.com | China | 92 | 58 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1846 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Biomatrik (Jiaxing) Inc. | 0573-82623377 18967387295 | sales@biomatrik.cn | China | 50 | 61 |
View Latest Price from DBCO-NHS Ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | DBCO-NHS ester
1353016-71-3
|
$30.00-76.00 | 99.04% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-10 | DBCO-NHS Ester
1353016-71-3
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-07 | DBCO-NHS ester
1353016-71-3
|
100mg | >99.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-NHS ester
1353016-71-3
- $30.00-76.00
- 99.04%
- TargetMol Chemicals Inc.
-
- DBCO-NHS Ester
1353016-71-3
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- DBCO-NHS ester
1353016-71-3
- $0.00
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
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