cephaeline
- CAS No.
- 483-17-0
- Chemical Name:
- cephaeline
- Synonyms
- Cefalin;Cepheline;Aids002677;cephaeline;Alangine B;Aids-002677;Cephaelinel;(-)-Cephaelin;Desmethylemetine;Dihydropsychotrine
- CBNumber:
- CB6904960
- Molecular Formula:
- C28H38N2O4
- Molecular Weight:
- 466.61
- MDL Number:
- MFCD14702530
- MOL File:
- 483-17-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 115-1160C |
|---|---|
| alpha | D20 -43.4° (c = 2 in chloroform) |
| Boiling point | 569.42°C (rough estimate) |
| Density | 1.21±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile: slightly soluble; Chloroform: slightly soluble; Ethanol: slightly soluble; Methanol: slightly soluble |
| form | A crystalline solid |
| pka | 9.90±0.40(Predicted) |
| color | Light yellow to yellow |
| Stability | Hygroscopic |
| FDA UNII | QA971541A1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H300 | |||||||||
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| RIDADR | 1544 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
cephaeline price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20916 | Cephaeline ≥95% | 483-17-0 | 500μg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 20916 | Cephaeline ≥95% | 483-17-0 | 1mg | $194 | 2026-04-30 | Buy |
| TRC | TRC-C256700-1MG | Cephaeline | 483-17-0 | 1mg | $215 | 2026-06-03 | Buy |
| Usbiological | 005939 | Cephaeline | 483-17-0 | 1mg | $523 | 2026-06-03 | Buy |
| Biosynth | FC19891 | Cephaeline | 483-17-0 | 1mg | $404.79 | 2026-06-04 | Buy |
cephaeline Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Cephaeline occurs in the ground roots ofipecac along with emetine. The Brazilian variety usually contains about 0.5%cephaeline. It is used as an emetic and anti amebic reagent.
Uses
Has been used as an emetic and expectorant
Definition
ChEBI: A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.
Health Hazard
The toxicity of cephaeline is lower than thatof emetine. The toxic effects are cumula tive. Ingestion of high doses may producehypotension, muscle weakness, and gastroin testinal problems, including nausea, vomiting, and diarrhea.
in vivo
Cephaeline (2 mg/kg, i.p.,daily for 3 days) suppresses ZIKV load and decreases the NS1 protein and ZIKV RNA in serum of ZIKV infected Ifnar1/ mice[2].
Cephaeline (5 mg/kg, i.p.,daily for 7 days) effectively suppressed EBOV infection in EBOV mouse models[3].
Cephaeline (5, 10 mg/kg, i.p., a single dose for 12 days) plays an anti-lung cancer role by inducing ferroptosis in tumor xenograft mouse model[4].
| Animal Model: | Ifnar1/ mice infected with ZIKV (8-9 week old, male and female)[2] |
| Dosage: | 2 mg/kg |
| Administration: | i.p.,daily for 3 days |
| Result: | Significantly lowered the serum viral load of ZIKV infected Ifnar1/ mice and decreased the NS1 protein and ZIKV RNA in serum and liver of mice, respectively. |
| Animal Model: | EBOV mouse model[3] |
| Dosage: | 5 mg/kg |
| Administration: | i.p., daily for 7 days |
| Result: | Achieved 67% survival in EBOV infection to death in EBOV mouse model. |
| Animal Model: | Tumor xenograft mouse model injected with the lung cancer H460 cell line[4] |
| Dosage: | 5, 10 mg/kg |
| Administration: | i.p., a single dose for 12 days |
| Result: | Showed significant antitumour effects in tumor xenograft mouse model. |
IC 50
EBOV
cephaeline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| WG reagent | 13391486464 | samwjf@163.com | China | 3082 | 55 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
View Lastest Price from cephaeline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Cephaeline
483-17-0
|
$123.00-413.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-29 | cephaeline
483-17-0
|
$2.00 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Cephaeline
483-17-0
- $123.00-413.00
- 99.94%
- TargetMol Chemicals Inc.
-
- cephaeline
483-17-0
- $2.00
- ≥98%
- Career Henan Chemical Co
