2-bromo-4-(trifluoromethyl)benzoic acid
- CAS No.
- 328-89-2
- Chemical Name:
- 2-bromo-4-(trifluoromethyl)benzoic acid
- Synonyms
- 3-Bromo-4-carboxybenzotrifluoride;2-BroM-4-trifluorMethyl-benzoesaeure;2-bromo-4-(trifluoromethyl)benzoicaci;2-Bromo-4-(trifluoromethl)benzoic acid;2-bromo-4-(trifluoromethyl)benzoic acid;Benzoic acid,2-broMo-4-(trifluoroMethyl)-;2-Bromo-4-(trifluoromethyl)benzoicacid,98%;2-Bromo-4-(trifluoromethyl)benzoic acid 97+%
- CBNumber:
- CB6916482
- Molecular Formula:
- C8H4BrF3O2
- Molecular Weight:
- 269.02
- MDL Number:
- MFCD07368837
- MOL File:
- 328-89-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
2-bromo-4-(trifluoromethyl)benzoic acid price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5334 | 2-Bromo-4-(trifluoromethyl)benzoic Acid >98.0%(GC)(T) | 328-89-2 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | B5334 | 2-Bromo-4-(trifluoromethyl)benzoic Acid >98.0%(GC)(T) | 328-89-2 | 5g | $144 | 2026-04-30 | Buy |
| Apolloscientific | PC11107 | 2-Bromo-4-(trifluoromethyl)benzoic acid 98% | 328-89-2 | 5g | $60 | 2026-06-04 | Buy |
| Activate Scientific | AS30785 | 2-Bromo-4-(trifluoromethyl)benzoic acid 98% | 328-89-2 | 1g | $35 | 2026-06-04 | Buy |
| Activate Scientific | AS30785 | 2-Bromo-4-(trifluoromethyl)benzoic acid 98% | 328-89-2 | 5g | $103 | 2026-06-04 | Buy |
2-bromo-4-(trifluoromethyl)benzoic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Synthesis
402-13-1
328-89-2
Example 5 Synthesis of 2-bromo-4-(trifluoromethyl)benzoic acid (Formula V, where R1 = H, R2 = CF3): 205 g (1 mol) of 2-amino-4-trifluoromethylbenzoic acid, 600 ml of glacial acetic acid, and 400 ml of 47% hydrobromic acid were added sequentially to a 3 liter round bottom flask. After the ingredients were completely dissolved, the reaction mixture was cooled to -10°C and diluted with 400 ml of water. Subsequently, a solution of 69 g (1 mol) of sodium nitrite dissolved in 200 ml of water was added dropwise while keeping the temperature below 0°C. After the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 2 hours. The above solution was slowly added dropwise to a 6-liter reactor pre-filled with 143.5 g (1 mol) of cuprous bromide dissolved in 500 ml of 47% hydrobromic acid and maintained at 60°C. After completion of dropwise addition, the reaction mixture was stirred at 60 °C for 1 h, then cooled to room temperature and poured into two liters of ice water. The precipitated solid was filtered through a sintered glass funnel, washed with water, and dried under a stream of air to give 216 g (yield: 80%) of 2-bromo-4-(trifluoromethyl)benzoic acid as a solid with a melting point of 118.5 °C. Note: See the literature for the preparation of 2-amino-4-(trifluoromethyl)benzoic acid (formula VI, where R1 = H and R2 = CF3).
References
[1] Patent: US5514719, 1996, A
[2] Synthesis (Germany), 2012, vol. 44, # 14, p. 2173 - 2180
[3] Patent: WO2005/54176, 2005, A1. Location in patent: Page/Page column 62
2-bromo-4-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
View Latest Price from 2-bromo-4-(trifluoromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 2-bromo-4-(trifluoromethyl)benzoic acid
328-89-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-bromo-4-(trifluoromethyl)benzoic acid
328-89-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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