arecoline
- CAS No.
- 63-75-2
- Chemical Name:
- arecoline
- Synonyms
- Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate;Arecolin;NSC 56321;ARECOLINE;Arecaidin;Methyl arecaidin;Methylarecaidine;Ephedrine alkaloid;Arecaidine Methyl Ester;arecoline ISO 9001：2015 REACH
- CBNumber:
- CB6930587
- Molecular Formula:
- C8H13NO2
- Molecular Weight:
- 155.19
- MDL Number:
- MOL File:
- 63-75-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | <25℃ |
|---|---|
| Boiling point | 209℃ |
| Density | 1.0504 g/cm3 (20 ºC) |
| refractive index | 1.4860 (589.3 nm 20℃) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Oil |
| pka | 6.84(at 25℃) |
| color | Oily liquid |
| InChI | InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3 |
| InChIKey | HJJPJSXJAXAIPN-UHFFFAOYSA-N |
| SMILES | C1N(C)CCC=C1C(OC)=O |
| LogP | 0.350 |
| FDA UNII | 4ALN5933BH |
arecoline price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0022545 | Arecoline 99.84% | 63-75-2 | 50mg | $32 | 2026-06-04 | Buy |
| ChemScene | CS-0022545 | Arecoline 99.84% | 63-75-2 | 100mg | $54 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1940869 | Arecoline >98%(HPLC) | 63-75-2 | 50mg | $80 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1940869 | Arecoline >98%(HPLC) | 63-75-2 | 100mg | $110 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1740527 | Arecoline 99.28% | 63-75-2 | 1mlx10mM(inDMSO) | $70 | 2026-05-06 | Buy |
arecoline Chemical Properties, Uses, Production
Description
Areca catechu L. (Bin Lang), a palm plant native to Malaysia, is mainly distributed in tropical regions of Asia and the Americas. Arecoline is extracted from dry mature seeds of areca. The mature seeds of areca are 3–5 cm in diameter, with fibrous peel and a seed, namely, areca nut. The endosperm of areca nut is hard, with grayish-brown spots. Areca nut is harvested from August to November every year before the fruit is fully mature. The seeds are peeled, boiled, and cut into thin slices. The dried slices are brown or black, and it is an important medicine in traditional Chinese medicine. Areca nut is the raw materials of catechu. Areca nut was used as anthelmintics with arecoline as the main alkaloid in it.
Chemical Properties
Oily Liquid
Physical properties
Appearance: oily liquid. Solubility: mixed with water, ethanol, or ether in any ratio, soluble in chloroform. Density: 1.059g/cm3 . Boiling point (760mmHg): 209°C. Flash point: 81.1°C. Vapor pressure (25°C): 0.208mmHg. Arecoline can be synthesized to salts with organic acids. Arecoline hydrobromide, arecoline acetarsol, and arecoline p-antimony carboxybenzoic acid are commonly used.
History
Arecoline, an alkaloid extracted from Areca catechu L., is first reported by Jahns in
1888. Mujumdar found that there were at least six kinds of alkaloids in areca,
including arecoline, arecaidine, guavacoline, and guavacine. The content of arecoline in the fresh fruit of areca was 0.3–0.63% as determined with HPLC .
It has been found first that arecoline has the effect of antiparasite and is promoting the motility of the gastrointestinal smooth muscle. It activates the M and N
cholinergic receptors, excites the nervous system, promotes the body excitability,
and improves the ability of learning and memory .
Uses
Arecoline has shown regulatory properties of controlling plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts.
Uses
Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
Definition
ChEBI: Arecoline is a tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine. It has a role as a muscarinic agonist and a metabolite. It is a tetrahydropyridine, an enoate ester, a pyridine alkaloid and a methyl ester.
Indications
This product has no source standard. Tablets: anthelmintics, less used now. Eye drops: cholinergic drugs for glaucoma treatment.
Pharmacology
Paralysis was the main mechanism of the antiparasite effect of arecoline.
The effect of arecoline on cholinergic receptors is similar to that of pilocarpine.
It can agonize M-cholinergic receptors (M1, M2, M3, M4) and increase the
secretion of glands, especially the salivary. It can also agonize N-cholinergic
receptors and activate the muscles of skeletal, ganglia, carotid body, etc. The central
nervous system is also influenced by the cholinergic effect of arecoline. Intravenous
injection of small dosage of arecoline can cause wake-up reaction of the cortex in
cats, which is inhibited or blocked by atropine. Arecoline can cause salivation, vomiting, diuretic, lethargy, and convulsion when overdosed.
In addition, arecoline can enhance intestinal peristalsis, contract bronchus, lower
heart rate, dilate blood vessels, and decrease blood pressure. While in rabbit, it
induces coronary artery contraction.
Eye drops can reduce the pupil.
Pharmacokinetic parameters for arecoline after oral administration of arecoline
(3 mg/kg): Tmax, 120.07 min; Cmax, 60.61 ng/mL; t1/2, 69.32 min; AUC0 – t,
15116.86 min/ng/mL; AUC0-∞, 15771.37 min/ng/mL; plasma clearance, 0.19 L/
min/kg .
Clinical Use
Arecoline is of historical interest, because its structure, like those of many other early medicinal agents, was determined and confirmed by a 19th-century German pharmacist, E. Jahns. Xanomeline may be viewed as a nonclassical bio-isostere of the ester moiety of arecoline. It is a muscarinic M1/M4 agonist that is showing promise in clinical trials for the treatment of Alzheimer's disease. Although it is not tolerated at orally effective doses, transdermal delivery systems are showing promise.
Safety Profile
Poison by subcutaneous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. It mimics the action of acetylcholine, a neurotransmitter, and is a parasympathetic nervous system stimulant. Its action on the central nervous system can cause tremors. Human mutation data reported. It is easily nitrosated to several nitrosamines. See also ESTERS and NITROSAMINES. It is the major alkaloid found in betel quid. Combustible, can react with oxidzing materials. When heated to decomposition it emits hghly toxic fumes of NOx.
arecoline Preparation Products And Raw materials
arecoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Envchem Bioscience (Shanghai) Co., Ltd. | 13012862996 | xuzhao0905@163.com | China | 280 | 58 |
| BOYAN PHARMA | 18566078841 18566078841 | tanyan@boyanpharma.com | China | 109 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2992 | 55 |
| Shanghai Wishpharma Co.,Ltd. | 021-56789108 18550363168 | 95413064@qq.com | China | 294 | 56 |
View Latest Price from arecoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | Arecoline
63-75-2
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-08-07 | Arecoline
63-75-2
|
$1.00-4.00 | 1KG | 99% | 1KG 100KG 1MT | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-15 | Arecoline
63-75-2
|
$40.00-92.00 | 98.00% | 10g | TargetMol Chemicals Inc. |
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