Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Structure
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate structure
CAS No.
22235-81-0
Chemical Name:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms
N-Isopropylnoratropine;YB-M2;Ipratropium Bromoam;N-Iso pyl Noratropine;Ipratropium Impurity E;N-DesMethyl IpratropiuM;Ipratropium Bromide Impurity 13;Ipratropium Bromide EP Impurity E;N-Isopropylnoratropine, 10 mM in DMSO;NIsopropylnoratropine,N Isopropylnoratropine
CBNumber:
CB6932642
Molecular Formula:
C19H27NO3
Molecular Weight:
317.42
MDL Number:
MFCD28898375
MOL File:
22235-81-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:29:37
Request For Quotation

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Properties

Melting point 112-114°C
Boiling point 448.8±45.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.12±0.10(Predicted)
color White to Pale Orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
REACH Registrations Active

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 1mg $49 2026-04-30 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 5mg $213 2026-04-30 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 10mg $283 2026-04-30 Buy
TRC TRC-I872680-50MG N-Isopropyl Noratropine >95%(HPLC) 22235-81-0 50mg $793 2026-06-03 Buy
TRC TRC-I872680-25MG N-Isopropyl Noratropine >95%(HPLC) 22235-81-0 25mg $431 2026-06-03 Buy
Product number Packaging Price Buy
18611 1mg $49 Buy
18611 5mg $213 Buy
18611 10mg $283 Buy
TRC-I872680-50MG 50mg $793 Buy
TRC-I872680-25MG 25mg $431 Buy

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemical Properties, Uses, Production

Chemical Properties

Off-White to Pale Orange Solid

Uses

N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.

Biological Activity

n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].

References

[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate synthesis

14510-37-3
22235-81-0
Synthesis of endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate from Acetyltropylic chloride

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Preparation Products And Raw materials

Raw materials

Noratropine endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Acetyltropylic chloride Ethyl phenylacetate Atropine
Acetone

1of2

Preparation Products

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Suppliers

Global Suppliers ( 67)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8039 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Nanjing XiZe Biotechnology CO., Ltd. 025-66023220 15250997978 1511893459@qq.com China 4777 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199 wxf@sungening.com China 9609 60
Sichuan jiayinglai technology CO.,LTD 9018 15982359653 1394531348@qq.com China 2271 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29090 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
Quality Control Solutions Ltd. 56
Nanjing XiZe Biotechnology CO., Ltd. 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 60
Sichuan jiayinglai technology CO.,LTD 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Dideu Industries Group Limited 58
TargetMol Chemicals Inc. 58

View Latest Price from endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate pictures 2026-09-17 endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
22235-81-0
 1kg 98%+ 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
N-Isopropylnoratropine pictures 2026-05-11 N-Isopropylnoratropine
22235-81-0
 $41.00-112.00 99.88% 10g TargetMol Chemicals Inc.

22235-81-0 (endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate) Related Search:

(endo,anti)-(±)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide Tropic acid Ipratropium bromide 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Benzenepropanoic acid, b-oxo-a-phenyl-, methyl ester
IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) α-(Hydroxymethyl)benzenacetic acid methyl ester DL-Tropic acid endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol (S)-Tropic acid
Pseudotropine Atropine Impurity 4 Tropinone Atropine littorine
(1R,2R,4S,5S,7s,9S)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Atropine-d5 Atropine sulfate

1of4

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester N-DesMethyl IpratropiuM α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E) Ipratropium Impurity E Ipratropium Bromide EP Impurity E Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester Ipratropium Bromide Impurity 13（Ipratropium Bromide EP Impurity E） endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine) N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E) Ipratropium Bromide Impurity 13 YB-M2 (1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity) NIsopropylnoratropine,N Isopropylnoratropine (1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate N-Isopropylnoratropine, 10 mM in DMSO Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester Ipratropium EP Impurity E/Desmethyl Ipratropium (USP) N-Isopropylnoratropine N-Iso pyl Noratropine Ipratropium Bromoam 22235-81-0 2235-81-0 Aroamtics, Pharmaceuticals, Intermediates & Fine Chemicals Aroamtics Intermediates & Fine Chemicals Pharmaceuticals