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ChemicalBook >> CAS DataBase List >>endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Structure
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate structure
CAS No.
22235-81-0
Chemical Name:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms
N-Isopropylnoratropine;YB-M2;Ipratropium Bromoam;N-Iso pyl Noratropine;Ipratropium Impurity E;N-DesMethyl IpratropiuM;Ipratropium Bromide Impurity 13;Ipratropium Bromide EP Impurity E;N-Isopropylnoratropine, 10 mM in DMSO;NIsopropylnoratropine,N Isopropylnoratropine
CBNumber:
CB6932642
Molecular Formula:
C19H27NO3
Molecular Weight:
317.42
MDL Number:
MFCD28898375
MOL File:
22235-81-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:29:37
Product description Number Pack Size Price
N-Isopropylnoratropine ≥98% 18611 1mg $49
N-Isopropylnoratropine ≥98% 18611 5mg $213
N-Isopropylnoratropine ≥98% 18611 10mg $283
N-Isopropylnoratropine ≥98% 18611 1mg $44
N-Isopropylnoratropine ≥98% 18611 5mg $193
More product size
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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Properties

Melting point 112-114°C
Boiling point 448.8±45.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.12±0.10(Predicted)
color White to Pale Orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
REACH Registrations Active

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 1mg $49 2026-04-30 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 5mg $213 2026-04-30 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 10mg $283 2026-04-30 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 1mg $44 2024-03-01 Buy
Cayman Chemical 18611 N-Isopropylnoratropine ≥98% 22235-81-0 5mg $193 2024-03-01 Buy
Product number Packaging Price Buy
18611 1mg $49 Buy
18611 5mg $213 Buy
18611 10mg $283 Buy
18611 1mg $44 Buy
18611 5mg $193 Buy

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pale Orange Solid

Uses

N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.

Biological Activity

n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].

References

[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate synthesis

14510-37-3
22235-81-0
Synthesis of endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate from Acetyltropylic chloride

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Preparation Products And Raw materials

Raw materials

Noratropine endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Acetyltropylic chloride Ethyl phenylacetate Atropine
Acetone

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Preparation Products

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Suppliers

Global( 67)Suppliers
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Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30224 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29094 58
Protheragen-ING 		+16313385890 info@protheragen-ing.com United States 3868 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
Supplier Advantage
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Dideu Industries Group Limited 		58
Protheragen-ING 		58
Aladdin Scientific 		58
Moxin Chemicals 		58

View Lastest Price from endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate pictures 2026-07-24 endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
22235-81-0
 1kg 98%+ 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
N-Isopropylnoratropine pictures 2026-05-11 N-Isopropylnoratropine
22235-81-0
 $41.00-112.00 99.88% 10g TargetMol Chemicals Inc.

22235-81-0(endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate)Related Search:

(endo,anti)-(±)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide DL-TROPIC ACID Tropic acid Ipratropium bromide 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER Benzenepropanoic acid, b-oxo-a-phenyl-, methyl ester IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Atropine Impurity 4
Tropinone Atropine littorine (S)-Tropic acid Pseudotropine
(1R,2R,4S,5S,7s,9S)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Atropine-d5 Atropine sulfate

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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester N-DesMethyl IpratropiuM α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E) Ipratropium Impurity E Ipratropium Bromide EP Impurity E Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester Ipratropium Bromide Impurity 13（Ipratropium Bromide EP Impurity E） endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine) N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E) Ipratropium Bromide Impurity 13 YB-M2 (1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity) NIsopropylnoratropine,N Isopropylnoratropine (1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate N-Isopropylnoratropine, 10 mM in DMSO Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester Ipratropium EP Impurity E/Desmethyl Ipratropium (USP) N-Isopropylnoratropine N-Iso pyl Noratropine Ipratropium Bromoam 22235-81-0 2235-81-0 Aroamtics, Pharmaceuticals, Intermediates & Fine Chemicals Aroamtics Intermediates & Fine Chemicals Pharmaceuticals