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2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran structure

CAS No.: 523-50-2

Chemical Name:: 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

Synonyms: ANGELICIN;ISOPSORALEN;angecin;ANGELICINE;NSC 404563;isopsoralin;ISOPSORALENE;ISOBERGAPTEN;ANGELICIN(P);Angelicin>

CBNumber:: CB9249112

Molecular Formula:: C11H6O3

Molecular Weight:: 186.16

MDL Number:: MFCD00064930

MOL File:: 523-50-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Angelicin	A0956	10mg	$301
Angelicin	A0956	25mg	$662
Angelicin >98.0%(GC)	A2573	25mg	$315
Angelicin ≥98%	11683	5mg	$108
Angelicin ≥98%	11683	10mg	$173
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2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Properties

Melting point	132-134°C
Boiling point	104°C/4mmHg(lit.)
Density	1.2477 (rough estimate)
refractive index	1.6310 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
color	White
λmax	302nm(EtOH)(lit.)
BRN	153970
InChI	InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
InChIKey	XDROKJSWHURZGO-UHFFFAOYSA-N
SMILES	C1(=O)OC2C3C=COC=3C=CC=2C=C1
LogP	2.080
CAS DataBase Reference	523-50-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	CZZ080D7BD
IARC	3 (Vol. 40, Sup 7) 1987
NIST Chemistry Reference	2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2)
UNSPSC Code	85151701
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P301+P312+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38-40

Safety Statements

26-36/37/39-37/39-36

WGK Germany

RTECS

LV0940000

HS Code

29322090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Hazardous Substances Data

523-50-2(Hazardous Substances Data)

NFPA 704

	0
3		0

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran price More Price(80)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A0956	Angelicin	523-50-2	10mg	$301	2026-04-30	Buy
Sigma-Aldrich	A0956	Angelicin	523-50-2	25mg	$662	2026-04-30	Buy
TCI Chemical	A2573	Angelicin >98.0%(GC)	523-50-2	25mg	$315	2026-04-30	Buy
Cayman Chemical	11683	Angelicin ≥98%	523-50-2	5mg	$108	2026-04-30	Buy
Cayman Chemical	11683	Angelicin ≥98%	523-50-2	10mg	$173	2026-04-30	Buy

Product number	Packaging	Price	Buy
A0956	10mg	$301	Buy
A0956	25mg	$662	Buy
A2573	25mg	$315	Buy
11683	5mg	$108	Buy
11683	10mg	$173	Buy

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Chemical Properties,Uses,Production

Synthesis

Iodination of commercially available umbelliferone (7-hydroxycoumarin) yields 7-hydroxy-8-iodocoumarin. Acetoxy group can be introduced into hydroxyl of 7-hydroxy-8-iodocoumarin, which is used to create vaginol or vaginidiol with an isopropyl Grignard reagent and commercially available epoxy aldehydes. Subsequent acid-catalysed fragmentation of vaginol with dichloromethane in trifluoroacetic acid yields angelicin.

Toxicity

The LD50 of angelicin is 322 mg/kg which shows acute toxicity if orally administered to rats. The possible consequences are alteration in circadian rhythm and righting reflex, ataxia and analgesia.

Description

Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (-) bacteria. It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC₅₀ = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta. Angelicin also weakly inhibits topoisomerase II (IC₅₀ = 404 μM).

Chemical Properties

White Solid

Uses

Antifungal

Definition

ChEBI: Angelicin is a furanocoumarin.

Synthesis Reference(s)

Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O

Clinical Use

Angelicin derivatives are used to treat psoriasis and cancer. One way of treating these diseases is by photochemotherapy (PUVA) which combines UV irradiation with photosensitizing chemical. Also, it was shown that it is actively inhibits the synthesis of nucleic acids in tumor cells thereby decreasing their growth.

References

[1] NAZNIN A. KHATUNE . Antibacterial compounds from the seeds of Psoralea corylifolia[J]. Fitoterapia, 2004, 75 2: Pages 228-230. DOI: 10.1016/j.fitote.2003.12.018
[2] HYUN CHO1. Bakuchiol: A Hepatoprotective Compound of Psoralea corylifolia on Tacrine-Induced Cytotoxicity in Hep G2 Cells[J]. Planta medica, 2001, 67 1: 750-751. DOI: 10.1055/s-2001-18347
[3] XIANG LI. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling.[J]. Phytotherapy Research, 2011, 25 10: 1574-1578. DOI: 10.1002/ptr.3478
[4] NAN JUN SUN. DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia[J]. Journal of Natural Products , 2003, 66 5: 734. DOI: 10.1021/np030135t

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Preparation Products And Raw materials

Raw materials

Xylene Sodium hydride Potassium hydroxide Ethyl formate Sodium chloride

Ethyl (triphenylphosphoranylidene)acetate 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Potassium hydride Chloroacetaldehyde Tetrahydrofuran

Diethyl ether Benzene Ethyl acetate Hydrochloric acid Sodium bicarbonate

Methanol 1,3-Cyclohexanedione Magnesium sulfate Petroleum ether

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Preparation Products

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Suppliers

Global( 372)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3618	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +86-18080483897	sales@biopurify.com	China	4616	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2971	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1922	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3861	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2934	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Angelicin 523-50-2			99.98%	10g	TargetMol Chemicals Inc.
2024-04-02	Angelicin 523-50-2	$1050.00	1g	98	500 Kg	R&D Scientific Inc.
2023-02-24	Isopsoralen 523-50-2		5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Angelicin
523-50-2
$0.00
99.98%
TargetMol Chemicals Inc.

Angelicin
523-50-2
$1050.00
98
R&D Scientific Inc.

Isopsoralen
523-50-2
$0.00
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Spectrum

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran(523-50-2)MS 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran(523-50-2)¹HNMR 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran(523-50-2)IR1 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran(523-50-2)IR2

523-50-2(2-Oxo-(2H)-furo(2,3-h)-1-benzopyran)Related Search:

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2-Oxo-(2H)-furo(2,3-h)-1-benzopyran STIGMASTEROL ACETATE Psoralen pimpinellin ISOBERGAPTOL

LANATIN ISOBERGAPTEN ISOBERGAPTEN(SH) 4,4',6-trimethylangelicin Acetamide, 2-dimethylamino-N-(4,8-dimethyl-2-oxo-2H-furo(2,3-h)-1-benz opyran-9-yl)-, hydrochloride

OROSELONE HERATOMIN AKOS 244-82

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ANGELICINE ISOBERGAPTEN ISOPSORALENE 2-OXO-[2H]-FURO[2,3-H]-1-BENZOPYRAN furo(5’,4’,7,8)coumarin furo(5’,4’:7,8)coumarin isopsoralin Isopsoralen （Angelicin） FURO(2,3-H)BENZOPYRAN-2-ONE ANGELICINE hplc PHYTOSTEROLE GRANULAR Angelicin【coumarin derivative】 ANGELICIN (BAKUCHICIN)(RG) ANGELICIN (BAKUCHICIN)(SH) ANGELICIN(P) isopsoralen 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Angelicin Isopsoralen 523-50-2 2-furo[2,3-h][1]benzopyranone NSC 404563 2H-Furo[2,3-h]chromen-2-one Angelicin, froM Psoralea corylifolia L. Angelicin, 98%, from Psoralea corylifolia L. 2h-furo(2,3-h)(1)benzopyran-2-one 2h-furo(2,3-h)-1-benzopyran-2-one 3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone 3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidgamma-lactone 4-hydroxy-5-benzofuranacrylicacidgamma-lactone angecin angelicin(coumarinderiv) furo(2,3-h)coumarin Angelicin> Angelicin-RM Phytosterole Granular(Angelicin) Angelicin[A0956] Angelicin (Standard) ANGELICIN ISOPSORALEN 523-50-2 BioChemical Apoptosis and Cell Cycle Cell Signaling and Neuroscience Cell Biology DNA metabolism DNA Intercalators and Crosslinkers Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Heterocycles Heterocyclic Compounds Coumarins Miscellaneous Natural Products