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ChemicalBook >> CAS DataBase List >>Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Structure
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester structure
CAS No.
657428-42-7
Chemical Name:
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester
Synonyms
tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate;EOS-60428;N-Boc-pyrazolopyrrolidine;5-Boc-4,6-Dihydro-1H-pyrr...;5-Boc-4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole;tert-butyl pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate;tert-butyl 1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5- carboxylate;tert-Butyl 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylate;tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxyla...;4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butyleste
CBNumber:
CB6958574
Molecular Formula:
C10H15N3O2
Molecular Weight:
209.24
MDL Number:
MFCD08061257
MOL File:
657428-42-7.mol
MSDS File:
SDS
Last updated:2026-05-28 01:54:38
Request For Quotation

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Properties

Boiling point 366.0±42.0 °C(Predicted)
Density 1.243±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 15.04±0.20(Predicted)
Appearance Light yellow to yellow Solid
InChI InChI=1S/C10H15N3O2/c1-10(2,3)15-9(14)13-5-7-4-11-12-8(7)6-13/h4H,5-6H2,1-3H3,(H,11,12)
InChIKey IBUNCTVDGYIKAP-UHFFFAOYSA-N
SMILES N1=CC2CN(C(OC(C)(C)C)=O)CC=2N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
HS Code  2933998090

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D6462 tert-Butyl 4,6-Dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 657428-42-7 1G $78 2026-04-30 Buy
TCI Chemical D6462 tert-Butyl 4,6-Dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 657428-42-7 5G $233 2026-04-30 Buy
Usbiological 433814 4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic Acid tert-Butyl Ester 657428-42-7 250mg $382 2026-06-03 Buy
Usbiological 433814 4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic Acid tert-Butyl Ester 657428-42-7 500mg $531 2026-06-03 Buy
Matrix Scientific 072148 4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 657428-42-7 250.00mg $138 2026-05-18 Buy
Product number Packaging Price Buy
D6462 1G $78 Buy
D6462 5G $233 Buy
433814 250mg $382 Buy
433814 500mg $531 Buy
072148 250.00mg $138 Buy

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Chemical Properties,Uses,Production

Uses

4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic Acid tert-Butyl Ester is an intermediate in the synthesis of Omarigliptin (O633100), a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as treatment for type 2 diabetes.

Synthesis

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE

157327-42-9

2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

1280210-79-8

Tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (1 g, 4.16 mmol, 1.00 eq.) was used as a raw material and dissolved in ethanol (10 mL) with hydrazine hydrate (340 mg, 6.79 mmol, 1.63 eq.). The mixed solution was stirred and reacted at room temperature for 5 hours. Upon completion of the reaction, the solvent was removed by vacuum concentration and the crude product obtained was purified by silica gel column chromatography with ethyl acetate/petroleum ether as eluent (the ratio was gradually adjusted from 1:5 to 1:2). Finally, 250 mg (29% yield) of tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate was obtained and the product was a yellow oil. The product was confirmed by LC/MS (Method C, ESI) analysis: retention time RT = 1.30 min, mass-to-charge ratio m/z ~ 210.0 [M + H]+.

References

[1] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 97; 98
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 19, p. 5361 - 5366
[3] Patent: EP3144310, 2017, A1

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Hydrazine hydrate Ethanol

Preparation Products

tert-butyl 1-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Suppliers

Global( 147)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Shanghai Pansopharm Technology Co., Ltd. 021-20962833 15316628753 sales@pansopharm.com China 863 60
Chengdu D-innovation Pharmaceutical Co.，LTD 028-85929779 18881048017 chenxuanruo@d-innovation.com China 208 58
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
ZEROSCHEM.CO.,LTD. 10-61256048 13810278579; sales@zeroschem.com China 1399 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Shanghai Pansopharm Technology Co., Ltd. 60
Chengdu D-innovation Pharmaceutical Co.，LTD 58
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
ZEROSCHEM.CO.,LTD. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55

View Lastest Price from Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester pictures 2024-11-26 Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester
657428-42-7
 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester pictures 2019-07-06 Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester
657428-42-7
 $1.00 1KG 99% Career Henan Chemical Co

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester Spectrum

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester(657428-42-7)1HNMR

657428-42-7(Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester)Related Search:

TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Canagliflozin heMihydrate 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester
Canagliflozin Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate
CPo3604-01 1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOLE 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE tert-butyl 3-amino-6-ethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate TERT-BUTYL 3'-AMINO-1'H-SPIRO[CYCLOPROPANE-1,6'-PYRROLO[3,4-C]PYRAZOLE]-5'(4'H)-CARBOXYLATE

1of4

5-Boc-4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole 5-Boc-4,6-Dihydro-1H-pyrr... tert-butyl 1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5- carboxylate Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester N-Boc-pyrazolopyrrolidine 4,6-Dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid tert-butyl ester tert-Butyl 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylate EOS-60428 tert-butyl pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxyla... 4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butyleste 4,6-Dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid tert-butyl ester 98% for Omarigliptin API tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 657428-42-7 Heterocycles series