ChemicalBook >> CAS DataBase List >>5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione structure

CAS No.: 2648939-40-4

Chemical Name:: 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Synonyms: Thalidomide-5,6-Cl;5,6-Dichloro-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 5,6-dichloro-2-(2,6-dioxo-3-piperidinyl)-;5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CBNumber:: CB69724796

Molecular Formula:: C13H8Cl2N2O4

Molecular Weight:: 327.12

MDL Number:: MFCD34167838

MOL File:: 2648939-40-4.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:32

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5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Properties

Boiling point	590.1±50.0 °C(Predicted)
Density	1.672±0.06 g/cm3(Predicted)
pka	10.52±0.40(Predicted)

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
BroadPharm	bp-40600	5,6-dichloro-thalidomide	2648939-40-4	50MG	$350	2026-05-24	Buy
BroadPharm	bp-40600	5,6-dichloro-thalidomide	2648939-40-4	100MG	$540	2026-05-24	Buy
BroadPharm	bp-40600	5,6-dichloro-thalidomide	2648939-40-4	250MG	$840	2026-05-24	Buy
aablocks	AA028VNI	5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 95.00%	2648939-40-4	50mg	$355	2026-06-02	Buy
aablocks	AA028VNI	5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 95.00%	2648939-40-4	100mg	$510	2026-06-02	Buy

Product number	Packaging	Price	Buy
bp-40600	50MG	$350	Buy
bp-40600	100MG	$540	Buy
bp-40600	250MG	$840	Buy
AA028VNI	50mg	$355	Buy
AA028VNI	100mg	$510	Buy

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Chemical Properties, Uses, Production

Uses

Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.

IC 50

Cereblon

References

[1] Zhang NN, et, al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.e16. DOI:10.1016/j.cell.2020.07.024

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	38900	58
Nantong Hanfang Biotechnology Co. , Ltd.	hanfangpharma@126.com 18017580634	hanfangpharma@126.com	China	25800	58
Henan Mengtai Pharmaceutical Technology Co., Ltd	17634413542	1959525201@qq.com	China	9011	58

Supplier	Advantage
Jilin Chinese Academy of Sciences-yanshen Technology	58
Nantong Hanfang Biotechnology Co. , Ltd.	58
Henan Mengtai Pharmaceutical Technology Co., Ltd	58

2648939-40-4 (5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione) Related Search:

Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

Thalidomide-O-C6-acid Thalidomide-4-O-C8-NH2 Thalidomide-O-C3-acid Thalidomide-4-O-C6-NH2 hydrochloride Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester

Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester Thalidomide-O-C5-acid N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Trifluoroacetate 6-Bromo-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

1of3

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Thalidomide-5,6-Cl 1H-Isoindole-1,3(2H)-dione, 5,6-dichloro-2-(2,6-dioxo-3-piperidinyl)- 5,6-Dichloro-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione 2648939-40-4