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CIPROXIFAN

CIPROXIFAN Structure
CIPROXIFAN structure
CAS No.
184025-19-2
Chemical Name:
CIPROXIFAN
Synonyms
CS-109;CIPROXIFAN;FUB359 Maleate;FUB-359 Maleate;FUB 359 Maleate;Ciproxifan Moleate;FUB 359 Maleate salt;Ciproxifan maleate, >=98%;Ciproxifan Maleate (FUB-359);Ciproxifan maleate, 10 mM in DMSO
CBNumber:
CB6972679
Molecular Formula:
C16H18N2O2.C4H4O4
Molecular Weight:
386.402
MDL Number:
MFCD06411563
MOL File:
184025-19-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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CIPROXIFAN Properties

storage temp. Store at -20°C
solubility DMSO: soluble32mg/mL
form powder
color white to beige
InChI 1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey RLQFKEYRALXXEJ-BTJKTKAUSA-N
SMILES OC(=O)\C=C/C(O)=O.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
FDA UNII 5EVQ7IRG99
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H335
Precautionary statements  P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38-43
Safety Statements  26-36/37/39
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
NFPA 704
0
2 0

CIPROXIFAN price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C6848 Ciproxifan maleate ≥98% (HPLC), powder 184025-19-2 5mg $197 2026-04-30 Buy
Sigma-Aldrich C6848 Ciproxifan maleate ≥98% (HPLC), powder 184025-19-2 25mg $686 2026-04-30 Buy
Cayman Chemical 29513 Ciproxifan (maleate) ≥98% 184025-19-2 1mg $37 2026-04-30 Buy
Cayman Chemical 29513 Ciproxifan (maleate) ≥98% 184025-19-2 5mg $132 2026-04-30 Buy
Cayman Chemical 29513 Ciproxifan (maleate) ≥98% 184025-19-2 10mg $246 2026-04-30 Buy
Product number Packaging Price Buy
C6848 5mg $197 Buy
C6848 25mg $686 Buy
29513 1mg $37 Buy
29513 5mg $132 Buy
29513 10mg $246 Buy

CIPROXIFAN Chemical Properties,Uses,Production

Description

Ciproxifan is a histamine H3 receptor antagonist (Ki = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H3 over histamine H1 and H2, M3 muscarinic, and α1D- and β1-adrenergic receptors (Kis = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, 5-HT3, and 5-HT4 (Kis = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED50 = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg.

Uses

Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.

Biochem/physiol Actions

Potent, selective H3 histamine receptor antagonist.

in vivo

Ciproxifan (1 mg/kg; a single p.o.) increases the t-MeHA level in mouse brain, with an ED50 of 0.14 mg/kg[1].
Ciproxifan (3 mg/kg, i.p.) improves the accuracy of responding in the five-choice task in rats only when the stimulus duration is 0.25 sec instead of 0.50 sec[1].
Ciproxifan (0.15-2 mg/kg; p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats[1].
Ciproxifan (1 mg/kg; a single i.v.) decreases the H3-receptor ligand concentration in serum in mice, with the half-lives (t1/2) of 13 and 87 min for the distribution and elimination phases in mice, respectively[1].
Ciproxifan (1 mg/kg; a single p.o.) exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice[1].

IC 50

H3 receptor: 9.2 nM (IC50)

References

[1] X LIGNEAU. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 287 2: 658-666.

CIPROXIFAN Preparation Products And Raw materials

Raw materials

Preparation Products

CIPROXIFAN Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 sales@uhnshanghai.com China 997 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
UHN Shanghai Research & Development Co., Ltd. 58
AdooQ BioScience, LLC 58
Shanghai HuanChuan Industry Co.,Ltd. 50
AdooQ Bioscience CHINA 60
LETOPHARM LIMITED 58
Sigma-Aldrich 80

View Lastest Price from CIPROXIFAN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ciproxifan maleate pictures 2026-07-15 Ciproxifan maleate
184025-19-2
 $73.00-227.00 99.45% 10g TargetMol Chemicals Inc.
(Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone pictures 2020-01-02 (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
184025-19-2
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

CIPROXIFAN Spectrum

CIPROXIFAN(184025-19-2)1HNMR

184025-19-2(CIPROXIFAN)Related Search:

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Ciproxifan Moleate FUB 359 Maleate FUB359 Maleate FUB-359 Maleate Ciproxifan maleate, >=98% Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt (4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate CIPROXIFAN FUB 359 maleate salt, Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt FUB 359 Maleate salt Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-, (Z)-2-butenedioate (1:1) Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone (2Z)-2-butenedioate Ciproxifan Maleate (FUB-359) (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone FUB 359 MALEATE;FUB359 MALEATE;FUB-359 MALEATE Ciproxifan maleate(FUB-359 maleate) CS-109 Inhibitor,aging,inhibit,Ciproxifan,disorders,Ciproxifan maleate,FUB359,Histamine Receptor,FUB-359,histamine,Alzheimer's (4-(3-(1H-Imidazol-4-yl)propoxy)phenyl)(cyclopropyl)methanone maleate Ciproxifan maleate, prototypic H3 inverse agonist / antagonist Ciproxifan maleate, 10 mM in DMSO 184025-19-2 C16H18N2O2C4H4O4 Inhibitors