LEPTOMYCIN A
- CAS No.
- 87081-36-5
- Chemical Name:
- LEPTOMYCIN A
- Synonyms
- PD-118607;NSC 369326;Antibiotic PD-118607;Antibiotic ATS-1287A;LEPTOMYCIN A USP/EP/BP;QECBVZBMGUAZDL-DLWOFZAMSA-N;ATS 1287A, PD 118607, JildaMycin;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
- CBNumber:
- CB6972730
- Molecular Formula:
- C32H46O6
- Molecular Weight:
- 526.7
- MDL Number:
- MFCD01711669
- MOL File:
- 87081-36-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 16-36/37-45 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 3822000000 | |||||||||
| NFPA 704 |
|
LEPTOMYCIN A price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 50μg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 100μg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 21762 | Leptomycin A ≥99% | 87081-36-5 | 500μg | $354 | 2026-04-30 | Buy |
| Usbiological | 453634 | Leptomycin A | 87081-36-5 | 50ug | $305 | 2026-06-03 | Buy |
| Usbiological | L1671-38 | Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin) >99%byHPLC| | 87081-36-5 | 100ug | $619 | 2026-06-03 | Buy |
LEPTOMYCIN A Chemical Properties, Uses, Production
Description
Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.
Uses
Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Uses
Leptomycin A is an antifungal antibiotic.
Definition
ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17.
IC 50
HIV-1
References
[1] NOBUAKI KUDO . Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1[J]. Experimental cell research, 1998, 242 2: Pages 540-547. DOI: 10.1006/excr.1998.4136
[2] YING WANG. Novel leptomycins from a streptomyces strain A92-308902: Inhibitors of the Nucleo-cytoplasmic translocation of the HIV-1 regulatory protein Rev[J]. Helvetica Chimica Acta, 2004, 80 7: 2157-2167. DOI: 10.1002/hlca.19970800715
LEPTOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Xilong Biochemical Technology Co., Ltd. | 021-52907766-8042 | China | 9928 | 58 | |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9957 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 | 15807197853@163.com | China | 3974 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
View Latest Price from LEPTOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Leptomycin A
87081-36-5
|
$210.00 | 10g | TargetMol Chemicals Inc. |
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- Leptomycin A
87081-36-5
- $210.00
- TargetMol Chemicals Inc.
