ZLc002
- CAS No.
- 308277-46-5
- Chemical Name:
- ZLc002
- Synonyms
- ZLc002;EX-A5758;(S)-ZLc002;ZLc002 ，E0496;EX A5758,EXA5758;EX-A5758, 10 mM in DMSO;Methyl (3-methoxy-3-oxopropanoyl)-L-valinate;L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
- CBNumber:
- CB69933477
- Molecular Formula:
- C10H17NO5
- Molecular Weight:
- 231.25
- MDL Number:
- MOL File:
- 308277-46-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 350.1±22.0 °C(Predicted) |
|---|---|
| Density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 46 mg/mL (198.92 mM);Ethanol: 46 mg/mL (198.92 mM) |
| pka | 12.22±0.46(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| Water Solubility | Water: 46 mg/mL (198.92 mM) |
| InChI | InChI=1S/C10H17NO5/c1-6(2)9(10(14)16-4)11-7(12)5-8(13)15-3/h6,9H,5H2,1-4H3,(H,11,12)/t9-/m0/s1 |
| InChIKey | BWPKYDAJBOUZDX-VIFPVBQESA-N |
| SMILES | C(OC)(=O)[C@H](C(C)C)NC(=O)CC(OC)=O |
ZLc002 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0866447 | (S)-ZLc002 98.0% | 308277-46-5 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-0866447 | (S)-ZLc002 98.0% | 308277-46-5 | 10mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0866447 | (S)-ZLc002 98.0% | 308277-46-5 | 25mg | $227 | 2026-06-04 | Buy |
| ChemScene | CS-0866447 | (S)-ZLc002 98.0% | 308277-46-5 | 50mg | $341 | 2026-06-04 | Buy |
| aablocks | AA023OCH | (S)-ZLc002 | 308277-46-5 | 10mg | $48 | 2026-06-01 | Buy |
ZLc002 Chemical Properties, Uses, Production
Uses
(S)-ZLc002 is a S-enantiomer of ZLc-002. ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain[1].
Biological Functions
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. It could disrupt binding between nNOS and NOS1AP using ex-vivo, in vitro, and purified recombinant systems. In vitro, ZLc002 reduced coimmunoprecipitation of full-length NOS1AP and nNOS in cultured neurons and HEK293T cells co-expressing full-length nNOS and NOS1AP[1].
Biological Activity
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.
References
[1] Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
[2] Wan-Hung Lee. “ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.” Molecular Pain 14 (2018): 1744806918801224.
ZLc002 Preparation Products And Raw materials
Raw materials
Preparation Products
ZLc002 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 237 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
