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2-Hydroxychalcone

2-Hydroxychalcone Structure
2-Hydroxychalcone structure
CAS No.
644-78-0
Chemical Name:
2-Hydroxychalcone
Synonyms
o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;HYDROXYCHALCONE,2-(AS);TRANS-2-HYDROXYCHALCONE;2-Hydroxychalcone, 98+%;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-Hydroxychalcone, 10 mM in DMSO
CBNumber:
CB7100356
Molecular Formula:
C15H12O2
Molecular Weight:
224.25
MDL Number:
MFCD00016449
MOL File:
644-78-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
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2-Hydroxychalcone Properties

Melting point 144-150 °C(lit.)
Boiling point 396.3±34.0 °C(Predicted)
Density 1.191±0.06 g/cm3(Predicted)
pka 9.26±0.35(Predicted)
form powder
color Yellow
BRN 2049134
CAS DataBase Reference 644-78-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29147000
NFPA 704
1
2 0

2-Hydroxychalcone price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S218170 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE AldrichCPR 644-78-0 1 unit $32.7 2026-04-30 Buy
Sigma-Aldrich S218170 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE AldrichCPR 644-78-0 25MG $29.8 2024-03-01 Buy
TCI Chemical H0234 2-Hydroxychalcone >98.0%(GC)(T) 644-78-0 5g $60 2025-07-31 Buy
TCI Chemical H0234 2-Hydroxychalcone >98.0%(GC)(T) 644-78-0 25g $180 2025-07-31 Buy
Biosynth FH43279 2-Hydroxychalcone 644-78-0 50g $213 2026-06-04 Buy
Product number Packaging Price Buy
S218170 1 unit $32.7 Buy
S218170 25MG $29.8 Buy
H0234 5g $60 Buy
H0234 25g $180 Buy
FH43279 50g $213 Buy

2-Hydroxychalcone Chemical Properties,Uses,Production

Description

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.

Uses

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Synthesis

A synthesis of 2-Hydroxychalcone was conducted using acetophenone and o-hydroxybenzaldehyde as starting materials. The reaction was catalyzed by potassium hydroxide and ethanol was used as the solvent.

in vitro

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.

References

[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576

2-Hydroxychalcone Preparation Products And Raw materials

Raw materials

Ethanol Potassium hydroxide Salicylaldehyde Acetophenone

Preparation Products

2-Hydroxychalcone Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Sinopharm Chemical Reagent Co,Ltd. 79
Dalian Meilun Biotech Co., Ltd. 58
9ding chemical ( Shanghai) Limited 55

View Lastest Price from 2-Hydroxychalcone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Hydroxychalcone pictures 2026-09-10 2-Hydroxychalcone
644-78-0
 $29.00 98.25% 10g TargetMol Chemicals Inc.

2-Hydroxychalcone Spectrum

2-Hydroxychalcone(644-78-0)MS2-Hydroxychalcone(644-78-0)1HNMR2-Hydroxychalcone(644-78-0)IR12-Hydroxychalcone(644-78-0)IR2

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BENZYLIDENE-2-HYDROXYACETOPHENONE (E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE HYDROXYCHALCONE, 2- 2-HYDROXYBENZYLIDENE ACETOPHENONE 2-(2-HYDROXYBENZAL)ACETOPHENONE 2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE (2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one 2-Hydroxychalcone, 98+% SALICYLALACETOPHENONE TRANS-2-HYDROXYBENZYLIDENEACETOPHENONE TRANS-2-HYDROXYCHALCONE 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one o-Hydroxychalcone α-(o-Hydroxybenzylidene)acetophenone 2-(2-Hydroxybenzal)acetophenone 2-(2-Hydroxybenzylidene)acetophenone Salicylalacetophenone 3-(2-hydroxyphenyl)-1-phenyl-2-propen-1-one 2-HYDROXYCHALCONE(UNSPECIFIEDISOMER) 2-Hydroxychalcone> 2-Propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl- 2-HYDROXYCHALCONE inhibit,Inhibitor,Apoptosis,Nuclear factor-κB,Nuclear factor-kappaB,NF-κB,TNBC,2 Hydroxychalcone,2-Hydroxychalcone,Bcl-2 Family,2Hydroxychalcone HYDROXYCHALCONE,2-(AS) 2-Hydroxychalcone, 10 mM in DMSO 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE 3-(2-hydroxyphenyl)-1-phenylpropyl-2-ene-1-one 644-78-0 44224-53-3 Ketones Organic Building Blocks Carbonyl Compounds C15 to C38 Building Blocks Chalcones, etc. (Building Blocks for Liquid Crystals) Flavonoids Building Blocks for Liquid Crystals Biochemistry Building Blocks for Liquid Crystals Chalcones, etc. (Building Blocks for Liquid Crystals) Flavonoids Functional Materials Chalcones