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2'-Hydroxychalcone

2'-Hydroxychalcone Structure
2'-Hydroxychalcone structure
CAS No.
1214-47-7
Chemical Name:
2'-Hydroxychalcone
Synonyms
(E)-1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-hydroxychalcone;2''-Hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone
CBNumber:
CB3771305
Molecular Formula:
C15H12O2
Molecular Weight:
224.25
MDL Number:
MFCD00016441
MOL File:
1214-47-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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2'-Hydroxychalcone Properties

Melting point 86-88 °C(lit.)
Boiling point 396.6±42.0 °C(Predicted)
Density 1.191±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Store below +30°C.
pka 7.77±0.30(Predicted)
form Solid
color Light yellow to yellow
BRN 976324
InChI InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H
InChIKey AETKQQBRKSELEL-UHFFFAOYSA-N
SMILES C(C1=CC=CC=C1O)(=O)C=CC1=CC=CC=C1
LogP 4.000 (est)
CAS DataBase Reference 1214-47-7(CAS DataBase Reference)
FDA UNII VY06DZ94OC
EPA Substance Registry System 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UD5579400
F  8
Autoignition Temperature 280 °C
TSCA  TSCA listed
HS Code  29145090
Toxicity mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986.
REACH Registrations Active
NFPA 704
1
2 0

2'-Hydroxychalcone price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14776 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis 1214-47-7 25g $76.4 2026-04-30 Buy
Sigma-Aldrich S449725 2'-HYDROXYCHALCONE AldrichCPR 1214-47-7 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 8.14776 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis 1214-47-7 100g $154 2026-04-30 Buy
Sigma-Aldrich S449725 2'-HYDROXYCHALCONE Aldrich 1214-47-7 250mg $179 2024-03-01 Buy
TCI Chemical H0385 2'-Hydroxychalcone >98.0%(HPLC) 1214-47-7 25g $71 2025-07-31 Buy
Product number Packaging Price Buy
8.14776 25g $76.4 Buy
S449725 1 unit $197 Buy
8.14776 100g $154 Buy
S449725 250mg $179 Buy
H0385 25g $71 Buy

2'-Hydroxychalcone Chemical Properties,Uses,Production

Chemical Properties

Yellow needle-like crystals (ethanol). Melting point 88-89°C.

Uses

2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.

Definition

ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.

Preparation

Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.

in vivo

2'-Hydroxychalcone (20-60 mg/kg; ip; every 2 days; 3 weeks) could exhibit an antitumor effect in vivo without causing significant toxicity to essential organs[1].

Animal Model:Five-week-old Balb/C female mice injected with CMT-1211 cells[1]
Dosage:20 mg/kg, 40 mg/kg, 60 mg/kg
Administration:Intraperitoneal injection; every 2 days; 3 weeks
Result:Suppressed tumor growth and metastasis in vivo.

2'-Hydroxychalcone Preparation Products And Raw materials

Raw materials

Preparation Products

Propafenone Hydrochloride

2'-Hydroxychalcone Suppliers

Global( 256)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Lingyan Biotechnology Co., Ltd 027-59304846 13297025796 2331003879@qq.com China 56 58
Hubei XinghengKang Chemical Technology Co., Ltd. 027-88878869 18162384755 xhkhu2014@163.com China 240 58
Hubei Lingyan Biotechnology Co., Ltd 13297025796 2331003879@qq.com China 334 58
Fuxin F-Block Pharmaceutical Co., Ltd. 15901742157 609923428@qq.com China 76 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Hubei Lingyan Biotechnology Co., Ltd 58
Hubei XinghengKang Chemical Technology Co., Ltd. 58
Hubei Lingyan Biotechnology Co., Ltd 58
Fuxin F-Block Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from 2'-Hydroxychalcone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-HYDROXYCHALCONE pictures 2026-09-02 2'-HYDROXYCHALCONE
1214-47-7
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
2'-Hydroxychalcone pictures 2026-08-25 2'-Hydroxychalcone
1214-47-7
 $85.00-850.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
2'-Hydroxychalcone pictures 2026-07-27 2'-Hydroxychalcone
1214-47-7
 $30.00-40.00 98.09% 10g TargetMol Chemicals Inc.
  • 2'-HYDROXYCHALCONE pictures
  • 2'-HYDROXYCHALCONE
    1214-47-7
  • $1.00-200.00
  • 99%, 99.5% Sublimated
  • Henan Fengda Chemical Co., Ltd
  • 2'-Hydroxychalcone pictures
  • 2'-Hydroxychalcone
    1214-47-7
  • $85.00-850.00
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd

2'-Hydroxychalcone Spectrum

2'-Hydroxychalcone(1214-47-7)MS2'-Hydroxychalcone(1214-47-7)1HNMR2'-Hydroxychalcone(1214-47-7)IR12'-Hydroxychalcone(1214-47-7)IR2

1214-47-7(2'-Hydroxychalcone)Related Search:

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1of4

2μ-Hydroxychalcone, 2-Hydroxybenzalacetophenone 2-Hydroxyphenylstyryl ketone 6'-Hydroxychalcone 2-Benzal-2'-hydroxyacetophenone 2-Benzylidene-2'-hydroxyacetophenone 3-Phenyl-1-(2-hydroxyphenyl)-2-propen-1-one 2-HYDROXYCHALC HYDROXYCHALCONE, 2'- BENZYLIDENE-(2-HYDROXYACETOPHENONE) Phenylvinylo-hydroxyphenylketone O-CINNAMOYLPHENOL Benzylidene(2-hydroxyacetophenone)~1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one 2'-HYDROXYCHALCONE 98% 2-HYDROXYCHALCONE(2'-HYDROXYISOMER) BENZYLIDENE-2'-HYDROXYACETOPHENONE 2-BENZAL-2'-HYDROXYACETOPHENONE 2-BENZYLIDENE-2'-HYDROXYACETOPHENONE 2-HYDROXYBENZALACETOPHENONE 1-(2-HYDROXYPHENYL)-3-PHENYL-2-PROPEN-1-ONE 1-(2-HYDROXYPHENYL)-3-PHENYL-2-PROPENONE 1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-on 2’-hydroxy-3-phenyl-acrylophenon 2-Hydroxybenzalacetophenone 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- 2-HydroxychalconeQ: What is 2-Hydroxychalcone Q: What is the CAS Number of 2-Hydroxychalcone Q: What is the storage condition of 2-Hydroxychalcone Q: What are the applications of 2-Hydroxychalcone 2'-HYDROXYCHALCONE 1214-47-7 2'-hydroxychalcone 2''-Hydroxychalcone 2''-Hydroxychalcone, 10 mM in DMSO 1-(2-Hydroxyphenyl)-3-phenylprop-2-en-1-one - [H92767] (E)-1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE 1214-47-7 C6H5CHCHCOC6H4OH Flavonoids Chalcones, etc. (Building Blocks for Liquid Crystals) Building Blocks for Liquid Crystals Organic Building Blocks Ketones Building Blocks C15 to C38 Carbonyl Compounds Biochemistry Building Blocks for Liquid Crystals Chalcones, etc. (Building Blocks for Liquid Crystals) Flavonoids Functional Materials