ChemicalBook >> CAS DataBase List >>7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile structure

CAS No.: 380844-49-5

Chemical Name:: 7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile

Synonyms: 7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile;Sulbactam-d5 Sodium;Bosutinib Impurity 31;Bosutinib Impurity 24;Bosutinib intermediate;1-Chloro-1-desmethylpiperazinyl-bosutinib;7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenylamino)-6-...;7-(3-chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile;7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile;3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-

CBNumber:: CB71010926

Molecular Formula:: C21H18Cl3N3O3

Molecular Weight:: 466.74

MDL Number:: MFCD09833975

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-09-12 18:54:26

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7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile Properties

Melting point	183-186℃
Boiling point	585.6±50.0 °C(Predicted)
Density	1.43
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly)
form	Solid
pka	3.71±0.50(Predicted)
color	Pale Yellow to Light Yellow
InChI	InChI=1S/C21H18Cl3N3O3/c1-28-18-9-17(14(23)7-15(18)24)27-21-12(10-25)11-26-16-8-20(30-5-3-4-22)19(29-2)6-13(16)21/h6-9,11H,3-5H2,1-2H3,(H,26,27)
InChIKey	GASHKCRNJZBFBE-UHFFFAOYSA-N
SMILES	N1C2C(=CC(OC)=C(OCCCCl)C=2)C(NC2=CC(OC)=C(Cl)C=C2Cl)=C(C#N)C=1
FDA UNII	H8BX2T3L3J

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-C423040-500MG	1-Chloro-1-desmethylpiperazinyl-bosutinib	380844-49-5	500mg	$599	2026-06-03	Buy
TRC	TRC-C423040-1G	1-Chloro-1-desmethylpiperazinyl-bosutinib	380844-49-5	1g	$1159	2026-06-03	Buy
TRC	TRC-C423040-100MG	1-Chloro-1-desmethylpiperazinyl-bosutinib	380844-49-5	100mg	$148	2026-06-03	Buy
Matrix Scientific	120696	7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile	380844-49-5	1.00g	$136	2026-05-18	Buy
Matrix Scientific	120696	7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile	380844-49-5	5.00g	$449	2026-05-18	Buy

Product number	Packaging	Price	Buy
TRC-C423040-500MG	500mg	$599	Buy
TRC-C423040-1G	1g	$1159	Buy
TRC-C423040-100MG	100mg	$148	Buy
120696	1.00g	$136	Buy
120696	5.00g	$449	Buy

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile Chemical Properties, Uses, Production

Uses

1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.

Synthesis

98446-49-2

4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE

214470-68-5

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE

380844-49-5

4-Chloro-7-(3-chloropropoxy)-6-methoxyquinoline-3-carbonitrile (31.2 g, 0.10 mol), 2,4-dichloro-5-methoxyaniline (21.1 g, 0.11 mol), and pyridine hydrochloride (12.8 g, 0.11 mol) were used as raw materials and mixed in 2-methoxyethanol (150 g). The reaction mixture was heated to 120 °C and maintained at this temperature for 3 hours. After completion of the reaction, the suspension was cooled to room temperature. The reaction mixture was slowly poured into water (600 g) under continuous stirring. The resulting solid product was collected by filtration and washed with water (2 x 40 g). Subsequently, the product was dried at 50 °C to afford 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-cyanoquinoline (35.9 g, 77% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR, 13C NMR and mass spectrometry (ESI).1H NMR (400 MHz, DMSO-d6) δ: 2.28 (m, J = 6.0 Hz, 2H), 3.82 (t, J = 6.0 Hz, 2H), 3.87 (s, 3H), 3.97 (s, 3H), 4.30 (t, J = 6.0 Hz, 2H). 7.35 (s, 1H), 7.37 (s, 1H), 7.75 (s, 1H), 7.85 (s, 1H), 8.43 (s, 1H), 9.63 (s, 1H).13C NMR (100 MHz, DMSO-d6) δ: 31.9, 42.1, 56.7, 57.3, 65.8, 86.9, 102.4, 110.0, 113.1, 114.0, 117.4, 120.9, 123.6, 130.3, 136.7, 146.2, 149.8, 149.9, 151.3, 152.9, 154.5. mass spectrum (ESI) m/z: 468.0 [M + H]+.

References

[1] Heterocycles, 2014, vol. 89, # 12, p. 2806 - 2813
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[3] Patent: CN103848785, 2016, B. Location in patent: Paragraph 0087; 0088
[4] Molecules, 2010, vol. 15, # 6, p. 4261 - 4266
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3965 - 3977

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-methoxyaniline 4-Chloro-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile 2-Methoxyethanol Pyridine hydrochloride

Preparation Products

Bosutinib

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile Suppliers

Global Suppliers ( 91)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	21-33585366 13311639313	sales@shyrchem.com	China	807	55
Biocompounds Pharmaceutical Inc.	21-57687675	yanjie@biocompounds.com	China	74	62
Taizhou Tongxin Bio-Tech Co., Ltd	0523-86818997 18652728585	sales@allyrise.com	China	2986	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Changzhou Idea-Works Medical Technology Co., Ltd	0519-83879978	sales@ideaworkspharm.com	China	85	62
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9739	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
Adamas Reagent, Ltd.	59
Jinan Trio PharmaTech Co., Ltd.	62
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	55
Biocompounds Pharmaceutical Inc.	62
Taizhou Tongxin Bio-Tech Co., Ltd	60
Bide Pharmatech Ltd.	60
Shanghai YuLue Chemical Co., Ltd.	55
Changzhou Idea-Works Medical Technology Co., Ltd	62
Credit Asia Chemical Co., Ltd.	58

View Latest Price from 7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 380844-49-5	$150.00	1KG	98%	200KG	Career Henan Chemical Co

7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile
380844-49-5
$150.00
98%
Career Henan Chemical Co

7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile Spectrum

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE(380844-49-5)¹HNMR

380844-49-5 (7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile) Related Search:

Bosutinib Impurity 3 Bosutinib Impurity 4 Bosutinib Impurity 6 Bosutinib Impurity 15 Bosutinib Impurity

5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate Bosutinib Bosutinib Monohydrate

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine 4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-Chloro-7-hydroxy-6-methoxy-quinoline-3-carbonitrile

4-Chloro-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile N-(2,4-Dichloro-5-hydroxyphenyl)acetamide 4-Chloro-7-fluoro-6-methoxy-quinoline-3-carbonitrile

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7-(3-chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile Bosutinib intermediate Bosutinib Impurity 24 Bosutinib Impurity 31 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy- 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE ISO 9001：2015 REACH 1-Chloro-1-desmethylpiperazinyl-bosutinib 7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenylamino)-6-... Sulbactam-d5 Sodium 7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 7-(3-Chloro-propoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-quinoline-3-carbonitrile 380844-49-5 C21H18Cl3N3O3