ChemicalBook >> CAS DataBase List >>7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE structure

CAS No.: 380844-49-5

Chemical Name:: 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE

Synonyms: Sulbactam-d5 Sodium;Bosutinib Impurity 31;Bosutinib Impurity 24;Bosutinib intermediate;1-Chloro-1-desmethylpiperazinyl-bosutinib;7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenylamino)-6-...;7-(3-chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile;7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile;7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE;3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-

CBNumber:: CB71010926

Molecular Formula:: C21H18Cl3N3O3

Molecular Weight:: 466.74

MDL Number:: MFCD09833975

MOL File:: Mol file

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 97%	120696	1g	$1440
7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile	3621CS	5g	$3160
7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 97%	120696	5g	$3960
7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 95%	CM145796	5g	$1477
7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile 95+%	CD11132362	5g	$1565
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7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Properties

Melting point	183-186℃
Boiling point	585.6±50.0 °C(Predicted)
Density	1.43
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly)
form	Solid
pka	3.71±0.50(Predicted)
color	Pale Yellow to Light Yellow
InChI	InChI=1S/C21H18Cl3N3O3/c1-28-18-9-17(14(23)7-15(18)24)27-21-12(10-25)11-26-16-8-20(30-5-3-4-22)19(29-2)6-13(16)21/h6-9,11H,3-5H2,1-2H3,(H,26,27)
InChIKey	GASHKCRNJZBFBE-UHFFFAOYSA-N
SMILES	N1C2C(=CC(OC)=C(OCCCCl)C=2)C(NC2=CC(OC)=C(Cl)C=C2Cl)=C(C#N)C=1
FDA UNII	H8BX2T3L3J

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	120696	7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 97%	380844-49-5	1g	$1440	2021-12-16	Buy
AK Scientific	3621CS	7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile	380844-49-5	5g	$3160	2021-12-16	Buy
Matrix Scientific	120696	7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 97%	380844-49-5	5g	$3960	2021-12-16	Buy
Chemenu	CM145796	7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenyl-amino)-6-methoxyquinoline-3-carbonitrile 95%	380844-49-5	5g	$1477	2021-12-16	Buy
Crysdot	CD11132362	7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile 95+%	380844-49-5	5g	$1565	2021-12-16	Buy

Product number	Packaging	Price	Buy
120696	1g	$1440	Buy
3621CS	5g	$3160	Buy
120696	5g	$3960	Buy
CM145796	5g	$1477	Buy
CD11132362	5g	$1565	Buy

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Chemical Properties,Uses,Production

Uses

1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.

Synthesis

98446-49-2

4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE

214470-68-5

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE

380844-49-5

4-Chloro-7-(3-chloropropoxy)-6-methoxyquinoline-3-carbonitrile (31.2 g, 0.10 mol), 2,4-dichloro-5-methoxyaniline (21.1 g, 0.11 mol), and pyridine hydrochloride (12.8 g, 0.11 mol) were used as raw materials and mixed in 2-methoxyethanol (150 g). The reaction mixture was heated to 120 °C and maintained at this temperature for 3 hours. After completion of the reaction, the suspension was cooled to room temperature. The reaction mixture was slowly poured into water (600 g) under continuous stirring. The resulting solid product was collected by filtration and washed with water (2 x 40 g). Subsequently, the product was dried at 50 °C to afford 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-cyanoquinoline (35.9 g, 77% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR, 13C NMR and mass spectrometry (ESI).1H NMR (400 MHz, DMSO-d6) δ: 2.28 (m, J = 6.0 Hz, 2H), 3.82 (t, J = 6.0 Hz, 2H), 3.87 (s, 3H), 3.97 (s, 3H), 4.30 (t, J = 6.0 Hz, 2H). 7.35 (s, 1H), 7.37 (s, 1H), 7.75 (s, 1H), 7.85 (s, 1H), 8.43 (s, 1H), 9.63 (s, 1H).13C NMR (100 MHz, DMSO-d6) δ: 31.9, 42.1, 56.7, 57.3, 65.8, 86.9, 102.4, 110.0, 113.1, 114.0, 117.4, 120.9, 123.6, 130.3, 136.7, 146.2, 149.8, 149.9, 151.3, 152.9, 154.5. mass spectrum (ESI) m/z: 468.0 [M + H]+.

References

[1] Heterocycles, 2014, vol. 89, # 12, p. 2806 - 2813
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[3] Patent: CN103848785, 2016, B. Location in patent: Paragraph 0087; 0088
[4] Molecules, 2010, vol. 15, # 6, p. 4261 - 4266
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3965 - 3977

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-methoxyaniline 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE 2-Methoxyethanol Pyridine hydrochloride

Preparation Products

Bosutinib

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8826	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20292	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15142	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24727	58

Supplier	Advantage
career henan chemical co	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Healthchem co.,ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 380844-49-5	US $150.00 / KG	1KG	98%	200KG	Career Henan Chemical Co

7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile
380844-49-5
US $150.00 / KG
98%
Career Henan Chemical Co

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Spectrum

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE(380844-49-5)¹HNMR

380844-49-5(7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE)Related Search:

Bosutinib Impurity 3 Bosutinib Impurity 4 Bosutinib Impurity 6 Bosutinib Impurity 15 Bosutinib Impurity

5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate Bosutinib

Bosutinib Monohydrate 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE

4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE

1of4

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE 7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 7-(3-chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile Bosutinib intermediate Bosutinib Impurity 24 Bosutinib Impurity 31 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy- 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE ISO 9001：2015 REACH 1-Chloro-1-desmethylpiperazinyl-bosutinib 7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenylamino)-6-... Sulbactam-d5 Sodium 380844-49-5 C21H18Cl3N3O3