2,4-Dichloro-5-methoxyaniline
- CAS No.
- 98446-49-2
- Chemical Name:
- 2,4-Dichloro-5-methoxyaniline
- Synonyms
- 5-Amino-2,4-Dichloroanisole;5-Amino-2,4-d;Bosutinib Impurity 12;Bosutinib Impurity 25;4,6-Dichloro-m-anisidine;Bosutinib Impurity 12 CRS;5-AMINO-4,6-DICHLOROANISOLE;2,4-DICHLORO-5-METHOXYANILINE;2,4-Dichloro-5-methhoxyaniline;5-Amino-2,4-dichloroanisole >
- CBNumber:
- CB9130874
- Molecular Formula:
- C7H7Cl2NO
- Molecular Weight:
- 192.04
- MDL Number:
- MFCD00974410
- MOL File:
- 98446-49-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 51 °C |
|---|---|
| Boiling point | 290.1±35.0 °C(Predicted) |
| Density | 1.375±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 1.59±0.10(Predicted) |
| color | Pale Brown |
| InChIKey | AJROJTARXSATEB-UHFFFAOYSA-N |
| CAS DataBase Reference | 98446-49-2(CAS DataBase Reference) |
| FDA UNII | YQ2NS3GL2B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H302-H312-H331-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN2810 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2922290090 | |||||||||
| NFPA 704 |
|
2,4-Dichloro-5-methoxyaniline price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2085 | 5-Amino-2,4-dichloroanisole >98.0%(GC)(T) | 98446-49-2 | 5g | $77 | 2026-04-30 | Buy |
| TCI Chemical | A2085 | 5-Amino-2,4-dichloroanisole >98.0%(GC)(T) | 98446-49-2 | 25g | $250 | 2026-04-30 | Buy |
| TRC | TRC-D434815-500MG | 2,4-Dichloro-5-methoxyaniline | 98446-49-2 | 500mg | $78 | 2026-06-03 | Buy |
| TRC | TRC-D434815-250MG | 2,4-Dichloro-5-methoxyaniline | 98446-49-2 | 250mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-D434815-100MG | 2,4-Dichloro-5-methoxyaniline | 98446-49-2 | 100mg | $59 | 2026-06-03 | Buy |
2,4-Dichloro-5-methoxyaniline Chemical Properties, Uses, Production
Uses
2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile
Synthesis
65182-98-1
98446-49-2
General procedure for the synthesis of 2,4-dichloro-5-methoxyaniline from N-(2,4-dichloro-5-methoxyphenyl)acetamide: N-(2,4-dichloro-5-methoxyphenyl)acetamide (100.7 g, 0.43 mol) was suspended in a mixture of ethanol (500 g), water (500 g), and concentrated hydrochloric acid (300 g, 3 mol), stirred and heated to 70 °C and the reaction lasted for 12 h to obtain a brown solution. After completion of the reaction, ethanol (about 200 g) was evaporated under reduced pressure and the remaining mixture was stirred and cooled to room temperature. After standing for 2 h, the precipitated solid was collected by filtration, washed with water (2 x 200 g) and dried under vacuum at 35 °C to afford 2,4-dichloro-5-methoxyaniline (69.4 g, 84% yield) as a light tan solid with a melting point of 49.5-51.1 °C (literature value 50.5-51.5 °C). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): 1H NMR δ= 3.76 (s, 3H), 5.13 (br s, 2H), 6.58 (s, 1H), 7.23 (s, 1H); mass spectrum (EI) m/z (relative abundance) = 191 (100).
References
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[2] Journal of the American Chemical Society, 1919, vol. 41, p. 460
2,4-Dichloro-5-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Idea-Works Medical Technology Co., Ltd | 0519-83879978 | sales@ideaworkspharm.com | China | 85 | 62 |
| Shanghai jing Hao pharmaceutical technology co., LTD | 021-68900963 15618693615 | sales@jinghaopharma.com | China | 300 | 58 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Enlian Biomedical (Chongqing) Co., Ltd. | 023-023-63134718 13983849334 | 1501533472@qq.com | China | 32 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 2,4-Dichloro-5-methoxyaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 2,4-Dichloro-5-methoxyaniline
98446-49-2
|
1kg | 99% | 20MT | Jinan Finer Chemical Co., Ltd | ||
 |
2026-06-30 | 2,4-Dichloro-5-methoxyaniline
98446-49-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-18 | 2,4-Dichloro-5-methoxyaniline
98446-49-2
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd |
-
- 2,4-Dichloro-5-methoxyaniline
98446-49-2
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 2,4-Dichloro-5-methoxyaniline
98446-49-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,4-Dichloro-5-methoxyaniline
98446-49-2
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
