DRONEDARONE HYDROCHLORIDE
- CAS No.
- 141625-93-6
- Chemical Name:
- DRONEDARONE HYDROCHLORIDE
- Synonyms
- Dronedarone HCl;Dronedarone hydrochloride, ≥98% (HPLC);CS-132;Multaq;SR33589;SR-33589B;CAS:141625-93-6;DRONEDARONE HCl CAS:;Multaq Hydrochloride.;SR33589 Hydrochloride
- CBNumber:
- CB71011211
- Molecular Formula:
- C31H44N2O5S.ClH
- Molecular Weight:
- 593.22
- MDL Number:
- MFCD00914940
- MOL File:
- 141625-93-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dronedarone hydrochloride ≥98% (HPLC) | D9696 | 10mg | $111 |
| Dronedarone hydrochloride European Pharmacopoeia (EP) Reference Standard | Y0002121 | 120 mg | $170 |
| Dronedarone hydrochloride United States Pharmacopeia (USP) Reference Standard | 1228530 | 125mg | $420 |
| Dronedarone Hydrochloride >98.0%(HPLC)(T) | D4689 | 200mg | $52 |
| Dronedarone Hydrochloride >98.0%(HPLC)(T) | D4689 | 1g | $152 |
| More product size | |||
| Melting point | NA (low-melting) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to off-white |
| Merck | 14,3449 |
| Stability | Hygroscopic |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
| SMILES | Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23 |
| FDA UNII | FA36DV299Q |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P501-P202-P201-P280-P308+P313-P405 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2935904000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
DRONEDARONE HYDROCHLORIDE price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D9696 | Dronedarone hydrochloride ≥98% (HPLC) | 141625-93-6 | 10mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0002121 | Dronedarone hydrochloride European Pharmacopoeia (EP) Reference Standard | 141625-93-6 | 120 mg | $170 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1228530 | Dronedarone hydrochloride United States Pharmacopeia (USP) Reference Standard | 141625-93-6 | 125mg | $420 | 2026-04-30 | Buy |
| TCI Chemical | D4689 | Dronedarone Hydrochloride >98.0%(HPLC)(T) | 141625-93-6 | 200mg | $52 | 2026-04-30 | Buy |
| TCI Chemical | D4689 | Dronedarone Hydrochloride >98.0%(HPLC)(T) | 141625-93-6 | 1g | $152 | 2026-04-30 | Buy |
DRONEDARONE HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
History
DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.
Uses
Dronedarone Hydrochloride can be used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.
Uses
Dronedarone Hydrochloride is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.
Uses
Cardiovascular Drugs
Biological Activity
dronedarone hcl is an amiodarone analogue which has been shown an effective and promising treatment for atrial fibrillation (af) [1].
Biochem/physiol Actions
Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.
Clinical Use
Dronedarone hydrochloride (also known as SR33589 and marketed as Multaq) is a drug developed by Sanofi-Aventis for cardiac arrhythmias (irregular heartbeat) that was approved by the FDA in July 2009. Dronedarone is used for the treatment of atrial fibrillation and atrial flutter in patients whose hearts have either returned to normal rhythm or who undergo drug therapy or electroshock treatment to maintain normal cardio rhythm. Dronedarone is less lipophilic than amiodarone, exhibits a much smaller volume of distribution and a half-life of 24 h, this stands in contrast to competitor amiodarone’s half-life of several weeks. As a result of these pharmacokinetic characteristics, dronedarone dosing may be less complicated than amiodarone.
Synthesis
The synthesis of dronedarone relies on the preparation of the benzofuran core 34, of which three main routes have been reported, but two possess obvious overlap and are considered more process-amenable. Starting from methyl 2-(2-formylphenoxy)hexanoate (32), this aldehyde can either be nitrated, then saponified or saponified and then nitrated to procure nitroacid 33 (the Scheme). The benzofuran ring is then secured through the use of acetic anhydride and base in the presence of DMF at elevated temperature. The key benzofuran 34 can be produced by either route in 62% yield on gramscale by this method. Friedel¨CCrafts acylation involving anisoyl chloride and tin tetrachloride constructed the diaryl ketone 35. Cleavage of the methyl ether through the use of aluminum trichloride in refluxing DCE provided phenol 36. Alkylation of phenol 36 with aminoalkyl chloride 37 gave ether 38. Subsequent reduction of the nitro group via catalytic hydrogenation and sulfonylation of the resulting amine provided dronedarone (VII) which was isolated as its HCl salt.
in vitro
dronedarone has been demonstrated to inhibit muscarinic acetylcholine receptor-operated k+ current ik(ach) induced by carbachol or gtp-gamma-s with ic50 values of 10nm and <100nm, respectively, in cells isolated from guinea pig atria. notably, dronedarone was 100-fold potent and selective over amiodarone in inhibiting ik(ach) [1].
in vivo
dronedarone has shown to block arterial thrombus formation, decrease platelet aggregation and reduce plasminogen activator inhibitor-1 (pai1) expression in c57bl/6 mice [2].
References
[1] guillemare e1, marion a, nisato d, gautier p. inhibitory effects of dronedarone on muscarinic k+ current in guinea pig atrial cells. j cardiovasc pharmacol. 2000 dec;36(6):802-5.
[2] breitenstein a1, sluka sh, akhmedov a, stivala s, steffel j, camici gg, riem hh, beer hj, studt jd, duru f, luscher tf, tanner fc. dronedarone reduces arterial thrombus formation. basic res cardiol. 2012 nov;107(6):302.
DRONEDARONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 556 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29091 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5986 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
View Lastest Price from DRONEDARONE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-08 | Dronedarone Hydrochloride
141625-93-6
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-09-08 | Dronedarone Hydrochloride
141625-93-6
|
1KG | 98.5%min | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-17 | Dronedarone hydrochloride
141625-93-6
|
$32.00-79.00 | 99.91% | 10g | TargetMol Chemicals Inc. |
-
- Dronedarone Hydrochloride
141625-93-6
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Dronedarone Hydrochloride
141625-93-6
- $0.00
- 98.5%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dronedarone hydrochloride
141625-93-6
- $32.00-79.00
- 99.91%
- TargetMol Chemicals Inc.
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