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S-Adenosyl-L-methionine Disulfate Tosylate

S-Adenosyl-L-methionine Disulfate Tosylate structure

CAS No.: 97540-22-2

Chemical Name:: S-Adenosyl-L-methionine Disulfate Tosylate

Synonyms: S-Adenosyl-L-methionine disulfate tosylate;AdeMethionine Disulfate Tosylate;S-ADENOSYL-L-METHIONINE DISULFATE P-TOLUENESULFONATE;SAM-T;S-adenosyl-L-methionine disulphate tosylate;fo-1561;SAME-PTS;SAMe Granular;Ademetionine disulfa;Ademetioninedisulfatetosylat

CBNumber:: CB7101717

Molecular Formula:: C22H34N6O16S4

Molecular Weight:: 766.78

MDL Number:: MFCD01674068

MOL File:: 97540-22-2.mol

MSDS File:: SDS

Last updated:2026-02-02 18:10:39

Product description	Number	Pack Size	Price
Ademetionine Disulfate Tosylate pharmaceutical secondary standard, certified reference material	PHR3168	1 g	$545.3
S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	16376	100mg	$117
S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	16376	50mg	$65
S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	16376	500mg	$520
S-Adenosyl-L-methionine Disulfate Tosylate	295234	50g	$237
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S-Adenosyl-L-methionine Disulfate Tosylate Properties

Melting point	>122°C (dec.)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly, Heated), Water (Sparingly)
form	Solid
color	White to Pale Yellow
Stability	Hygroscopic
Major Application	pharmaceutical
InChIKey	XDCFCHNAIMYBAZ-DUXZMFTLNA-N
SMILES	S(C1C=CC(C)=CC=1)(O)(=O)=O.S(O)(O)(=O)=O.O[C@@H]1[C@@H]([C@@H](C[S+](C)CC[C@H](N)C(=O)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.S(O)([O-])(=O)=O \|&1:17,18,19,25,31,r\|
CAS DataBase Reference	97540-22-2(CAS DataBase Reference)
FDA UNII	564ROC9U09
NCI Drug Dictionary	S-adenosyl-L-methionine disulfate p-toluene-sulfonate
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314-H318

Precautionary statements

P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P280-P305+P351+P338-P310

Risk Statements

36/37/38

Safety Statements

24/25

WGK Germany

WGK 3

HS Code

2934990002

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

S-Adenosyl-L-methionine Disulfate Tosylate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3168	Ademetionine Disulfate Tosylate pharmaceutical secondary standard, certified reference material	97540-22-2	1 g	$545.3	2025-07-31	Buy
Cayman Chemical	16376	S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	97540-22-2	100mg	$117	2021-12-16	Buy
Cayman Chemical	16376	S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	97540-22-2	50mg	$65	2021-12-16	Buy
Cayman Chemical	16376	S-(5'-Adenosyl)-L-methionine (sulfate tosylate) ≥95%	97540-22-2	500mg	$520	2021-12-16	Buy
Usbiological	295234	S-Adenosyl-L-methionine Disulfate Tosylate	97540-22-2	50g	$237	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR3168	1 g	$545.3	Buy
16376	100mg	$117	Buy
16376	50mg	$65	Buy
16376	500mg	$520	Buy
295234	50g	$237	Buy

S-Adenosyl-L-methionine Disulfate Tosylate Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Uses

Ademetionine Disulfate Tosylate is used to study the survival time in various damage brain models.

Application

S-Adenosyl-L-methionine Disulfate Tosylate (SAMe-ST) is the tosylate disulphate form of S-adenosyl-L-methionine (SAM). SAM may serve as an adjunctive therapy for refractory major depressive disorder. SAMe-ST is a multifunctional biochemical agent exhibiting antidepressant, anticancer and hepatoprotective properties. It may be administered as a dietary supplement for the management of depressive disorders and hepatic conditions.

Definition

The density of Ademethionine Disulfate Tosylate is typically between 1.42-1.48 g/cm³. Its unique characteristics make it an ideal compound for various health supplements and pharmaceuticals. The compound is commonly packaged in sealed containers and transported at controlled temperatures to ensure its integrity and purity. It is manufactured through synthetic procedures involving the reaction between adenosine triphosphate (ATP) and methionine. Ademethionine Disulfate Tosylate is typically used for its therapeutic effects, which range from improving liver function to providing relief from depression and arthritis. It is used extensively in treating liver diseases and is known to enhance liver cell regeneration, promote bile flow, and improve overall liver function. SAMe is also known for its anti-inflammatory properties, which make it effective in reducing the symptoms of conditions such as osteoarthritis and depression.

Biosynthesis

Ademethionine Disulfate Tosylate (SAME) is made in the body from methionine, an amino acid found in foods.

Biological Activity

Studies have shown that S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) at concentrations of 0.2 to 5.0 mg/ml protects red blood cells from hypotonic hemolysis, and that this protection is attributed to the SAMe moiety itself, rather than its Sulfate or mesylate moiety. SAMe-ST significantly increased Na+.K(+)-ATPase activity^[1].

Side effects

Ademethionine Disulfate Tosylate is likely safe. Side effects might include gas, diarrhea, constipation, dry mouth, headache, and nervousness, especially at higher doses.

References

[1] M TSUJI;K O;K Kodama. Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.[J]. Japanese journal of pharmacology, 1990. DOI:10.1254/jjp.52.45.

S-Adenosyl-L-methionine Disulfate Tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

S-Adenosyl-L-methionine Disulfate Tosylate Suppliers

Global( 429)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	1713330907@QQ.com	China	2639	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	1287	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	5947	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	477	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	302	58
Sach biotech Co.,Ltd	+8615888865902	sales@hzsqchem.com	China	63	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	112	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	+86-86-057182358004 +8613588879771	info@weitai-pharmaceutical.com	China	61	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Shandong Luning Pharmaceutical Co., Ltd.	+8618753388868	sale@lntzkg.com	China	7	58

Supplier	Advantage
Shaanxi LonierHerb Bio Technology Co Ltd	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	58
BINBO BIOLOGICAL CO.,LTD	58
Hangzhou Hyper Chemicals Limited	58
Sach biotech Co.,Ltd	58
Xinxiang Aurora Biotechnology Co.,Ltd.	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shandong Luning Pharmaceutical Co., Ltd.	58

Related Qustion

Ask a question

Q:What is the use and benefits of Ademethionine Disulfate Tosylate（SAME）?Zora - Nov 4，2025

A:Ademethionine Disulfate Tosylate （SAME）is an active pharmaceutical ingredient (API) used in the production of certain medications and supplements. SAMe is commonly used for its antidepressant and anti-inflammatory properties and is often prescribed for the treatment of depression, osteoarthritis, and liver diseases. It works by increasing the levels of certain neurotransmitters in the brain and also has antioxidant and protective effects on the liver.

View Lastest Price from S-Adenosyl-L-methionine Disulfate Tosylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-20	Ademetionine disulfate tosylate 97540-22-2			0.99		RongNa Biotechnology Co.,Ltd
2026-02-15	Ademethionine Disulfate Tosylate 97540-22-2	US $0.00 / kg	0.001kg	99.99%	20tons	Anhuyan (Hainan) Biotechnology Co., LTD
2026-02-15	Ademethionine Disulfate Tosylate 97540-22-2	US $1.00 / kg	0.000165kg	99%	200kg	Jinan Million Pharmaceutical Co., Ltd

Ademetionine disulfate tosylate
97540-22-2
0.99
RongNa Biotechnology Co.,Ltd

Ademethionine Disulfate Tosylate
97540-22-2
US $0.00 / kg
99.99%
Anhuyan (Hainan) Biotechnology Co., LTD

Ademethionine Disulfate Tosylate
97540-22-2
US $1.00 / kg
99%
Jinan Million Pharmaceutical Co., Ltd

S-Adenosyl-L-methionine Disulfate Tosylate Spectrum

Ademetionine disulfate tosylate(97540-22-2)¹HNMR

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SAM-T(S-Adenosyl-5-L-Methionine Tosylate) S-Adenosyl-L-Methionine disulfate tosylate(SAM-T) S-adenisyl-L-Methioninedisulfate-p-toluenesulfonate SAM-T AdeMethionine Disulfate Tosylate S-Adenosyl-L-Methionine Disulfate p-Toluenesulfonate (Mixture of Diastereomers) Ademetionine disulfate tosylate S-Adenosyl-L-methionine disulfate tosylate Ademetionine Disulfate Tosylate (500 mg) (S-Adenosyl-L-Methionine Disulfate Tosylate) S-(5'-Adenosyl)-L-methionine (sulfate tosylate) S-Adenosyl-L-methionine disulfate tosylateUSP, 95.0-105.0% (Assay) Ademetionine Disulfate Tosylate(SAMe) SAM-TAdemetionine disulfate tosylate S-(5'-Adenosyl)-L-methionine (tosylate) 5’-((3-amino-3-carboxypropyl)methylsulfonio)-5’-deoxy-adenosin(s)-adenosinsaltw adenosylmethioninetosylatebis(sulfate fo-1561 ith4-methylbenzenesulfonicacid,sulfate(salt)(1:1:2) S-ADENOSYL-L-METHIONINE SULFATE P-TOLUENESULFONATE S-ADENOSYL-L-METHIONINE SULFATE TOSYLATE SAME-PTS S-adenosyl-L-methionine disulphate tosylate S-ADENOSYL-L-METHIONINE DISULFATE P-TOLUENESULFONATE Ademetionine Disulfate Tosylate (500 mg) Ademetionine disulfa 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine disulfate 4-methylbenzenesulfonate Ademetionine disulfate tosylate S-Adenosyl-L-methionine disulfate tosylate ADEMETHIONINE SULFATE TOSYLATE Ademethionine Disulfate Tosylate (> Adenosine,5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-, sulfate(salt), 4-methylbenzenesulfonate (salt) sulfate (salt) (1:1:1:1) Ademetionine disulfate tosylate USP/EP/BP Ademethionine Disulfate Tosylate (>90%) Ademetioninedisulfatetosylat Manufacturer Supply 99% Bulk S-Adenosyl-L-Dl-Methionine Sam-E CAS 97540-22-2 S-Adenosyl-L-methionine Disulfate Tosylate （SAME） ((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium hydrogen sulfate 4-methylbenzenesulfonate sulfate S- adenosylmethionine p-toluenesulfonic acid sulfate S-Adenosyl-L-methionine disulf Adenosine, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-, sulfate, 4-methylbenzenesulfonate sulfate (1:1:1:1) 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-Adenosine sulfate 4-methylbenzenesulfonate sulfate (1:1:1:1) (2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate 4-methylbenzenesulfonate bis(sulfate) S-adenosyl-L-methionine disulfate p-toluensulfonate P-Toluenesulfonic acid disulfide adenosine methionine P-Toluenesulfonic Acid Adenosine Sulfate Methionine SAM e (S-(5-Adenosyl)-L-methionine disulfate tosylate), Methyl donor S-Adenosyl-L-methionine disulfate tosylate, 10 mM in DMSO S-Adenosylmethionine p-Toluenesulfonate Sulfate SAMe Granular Ademetionine disulfate tosylate(SAM-T) Ademethionine Disulfate Tosylate SAME 5'-[[(3S)-3-Amino-3-carboxy-propyl]methylsulfonio]-5'-deoxy-adenosine sulfate tosylate sulfate (1:1:1:1) Ademetionine disodium tosylate 97540-22-2 C7H8O3SC15H22N6O5S2H2O4S C22H32N6O15S4 C22H35N6O16S4 C22H36N6O16S4 C22H34N6O16S4