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ChemicalBook >> CAS DataBase List >>(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Structure
(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL structure
CAS No.
139290-65-6
Chemical Name:
(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
Synonyms
VOLINANSERIN;M 100907;MDL100907;R-MDL 100907;MDL 100907 NEW;MDL100907-L-tartrate;MDL100907 tartrate salt;MDL 100907 (MDL-100907;MDL-100907(Volinanserin);Volinanserin (MDL100907)
CBNumber:
CB7103504
Molecular Formula:
C22H28FNO3
Molecular Weight:
373.46
MDL Number:
MFCD00909060
MOL File:
139290-65-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
M100907 ≥98% (HPLC) M3324 5mg $182
M100907 ≥98% (HPLC) M3324 25mg $763
Volinanserin ≥95% 15936 1mg $30
Volinanserin ≥95% 15936 5mg $97
Volinanserin ≥95% 15936 10mg $164
More product size
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(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Properties

Melting point 89-91°C
Boiling point 499.4±45.0 °C(Predicted)
Density 1.150±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka 13.93±0.20(Predicted)
form powder
color off-white to light brown
InChI 1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
InChIKey HXTGXYRHXAGCFP-OAQYLSRUSA-N
SMILES COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC
FDA UNII EW71EE171J
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Storage Class 11 - Combustible Solids

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M3324 M100907 ≥98% (HPLC) 139290-65-6 5mg $182 2026-04-30 Buy
Sigma-Aldrich M3324 M100907 ≥98% (HPLC) 139290-65-6 25mg $763 2026-04-30 Buy
Cayman Chemical 15936 Volinanserin ≥95% 139290-65-6 1mg $30 2026-04-30 Buy
Cayman Chemical 15936 Volinanserin ≥95% 139290-65-6 5mg $97 2026-04-30 Buy
Cayman Chemical 15936 Volinanserin ≥95% 139290-65-6 10mg $164 2026-04-30 Buy
Product number Packaging Price Buy
M3324 5mg $182 Buy
M3324 25mg $763 Buy
15936 1mg $30 Buy
15936 5mg $97 Buy
15936 10mg $164 Buy

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Chemical Properties,Uses,Production

Description

Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM). It weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters. Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.

Chemical Properties

Colourless solid

Uses

As a serotonin 5-HT2A receptor antagonist, Volinanserin Hydrochloride Salt can be used as potential controls in various biological studies.

Uses

Volinanserin is a serotonin receptor 5-HT2A antagonist; anti-psychotic.

General Description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

storage

+4°C

References

[1] S M SORENSEN. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 266 2: 684-691.
[2] J H KEHNE. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 2: 968-981.
[3] ELIZABETH A PEHEK. Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex[J]. Neuropsychopharmacology, 2005, 31 2: 265-277. DOI: 10.1038/sj.npp.1300819
[4] PAUL A ARDAYFIO. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 327 3: 891-897. DOI: 10.1124/jpet.108.143370
[5] LAURA J. BOOTHMAN  Trevor S  Stephen N Mitchell. Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis[J]. Neuropharmacology, 2006, 50 6: Pages 726-732. DOI: 10.1016/j.neuropharm.2005.11.020
[6] VERN LEWIS. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders.[J]. Cell reports, 2023, 42 3: 112203. DOI: 10.1016/j.celrep.2023.112203

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Suppliers

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5757 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49860 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Suzhou ARTK Medchem Co., Ltd. 		+86-18168183658 sales1@artkmedchem.com China 39007 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53799 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Supplier Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
BOC Sciences 65

View Lastest Price from (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Volinanserin pictures 2026-06-02 Volinanserin
139290-65-6
 $80.00-245.00 99.63% 10g TargetMol Chemicals Inc.
  • Volinanserin pictures
  • Volinanserin
    139290-65-6
  • $80.00-245.00
  • 99.63%
  • TargetMol Chemicals Inc.

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Spectrum

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL(139290-65-6)1HNMR

139290-65-6((R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL)Related Search:

4-(3-METHOXY-BENZYL)-PIPERIDINE ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL CHEMBRDG-BB 4010734 4-(2-METHOXY-BENZYL)-PIPERIDINE 3-PIPERIDIN-4-YLMETHYL-PHENOL
PHENYL-PIPERIDIN-4-YL-METHANOL (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL (+/-)-ALPHA-(2,3-DIMETHOXY-PHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINE-METHANOL Volinanserin Hydrochloride Salt

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(+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol M 100907 R-MDL 100907 (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol (R,R)-tartrate 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R), (R,R)-tartrate MDL100907-L-tartrate (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R) MDL100907 tartrate salt (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride Volinanserin Hydrochloride Salt (+)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride (αR)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride MDL-100907(Volinanserin) (R)-(+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (R)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol 4-piperidinemethanol, a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (ar)- MDL100907 4-PIPERIDINEMETHANOL, 1-[2-(4-FLUOROPHENYL)ETHYL]-ALPHA-(2,3-DIMETHOXYPHENYL)-, (ALPHAR) (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol MDL 100907 (MDL-100907 MDL 100907 NEW Volinanserin (MDL100907) Serotonin Receptor,inhibit,MDL 100907,5-HT Receptor,M-100907,5-hydroxytryptamine Receptor,Inhibitor,Volinanserin,M100907,MDL-100907 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)- Volinanserin, 10 mM in DMSO VOLINANSERIN 139290-65-6 C22H29ClFNO3 C22H28FNO3C4H6O6 C22H28FNO3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals