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ChemicalBook >> CAS DataBase List >>(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Structure
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride structure
CAS No.
117857-45-1
Chemical Name:
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
Synonyms
Loreclezole;R-72063;LoreclezoleHCl;Loreclezole, 10 mM in DMSO;1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole;(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole;1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-;(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride;γ-Aminobutyric acid Receptor,R 72063,Inhibitor,GABA Receptor,Loreclezole,Gamma-aminobutyric acid Receptor,R72063,R-72063,inhibit
CBNumber:
CB71075257
Molecular Formula:
C10H6Cl3N3
Molecular Weight:
274.53
MDL Number:
MFCD00865331
MOL File:
117857-45-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:16:10
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(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Properties

storage temp. Inert atmosphere,2-8°C
solubility <1.37mg/ml in DMSO; <1.37mg/ml in ethanol
form Solid
color White to off-white
InChI 1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-
InChIKey XGLHZTBDUXXHOM-WMZJFQQLSA-N
SMILES Cl/C(C1=CC=C(Cl)C=C1Cl)=C\N2N=CN=C2
FDA UNII 6DJ32STZ5W
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich JN0002 Loreclezole ≥98% (HPLC) 117857-45-1 5 mg $107 2026-04-30 Buy
Sigma-Aldrich JN0002 Loreclezole ≥98% (HPLC) 117857-45-1 25 mg $435 2026-04-30 Buy
Usbiological 255704 Loreclezole hydrochloride Asreported 117857-45-1 10mg $466 2026-06-03 Buy
Usbiological 255704 Loreclezole hydrochloride Asreported 117857-45-1 50mg $1281 2026-06-03 Buy
Biosynth SEA85745 Loreclezole 117857-45-1 5mg $247.4 2026-06-05 Buy
Product number Packaging Price Buy
JN0002 5 mg $107 Buy
JN0002 25 mg $435 Buy
255704 10mg $466 Buy
255704 50mg $1281 Buy
SEA85745 5mg $247.4 Buy

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Chemical Properties, Uses, Production

Uses

Anti-epileptic.

Definition

ChEBI: 1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole is a dichlorobenzene.

Biological Activity

Subtype-selective GABA A receptor modulator. Acts as a positive allosteric modulator of β 2 or β 3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA A receptor sensitization. Inhibits homomeric ρ 1 GABA C receptors.

in vivo

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the "pull-up" test[3].

Animal Model:Adult male Lister Hooded rats[3].
Dosage:10, 25, 50 or 75 mg/kg.
Administration:IP, 60 min before measurement of seizure threshold.
Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Suppliers

Global Suppliers ( 50)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Henan Alfachem Co.,Ltd. 0371-55051623 18137891487 3983243027@qq.com China 9974 58
Shanghai Yu Ben Biotechnology Co., Ltd. 021-61350663 15502154572 1639466865@qq.com China 499 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
EMMX Biotechnology LLC 60
Amadis Chemical Company Limited 58
Henan Alfachem Co.,Ltd. 58
Shanghai Yu Ben Biotechnology Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58
TargetMol Chemicals Inc. 58
InvivoChem 58

View Latest Price from (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Loreclezole pictures 2026-05-11 Loreclezole
117857-45-1
 $31.00-103.00 99.94% 10g TargetMol Chemicals Inc.
  • Loreclezole pictures
  • Loreclezole
    117857-45-1
  • $31.00-103.00
  • 99.94%
  • TargetMol Chemicals Inc.

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Spectrum

(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride(117857-45-1)1HNMR

117857-45-1 ((Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride) Related Search:

Mefentrifluconazole (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride 2,4-Dichlorobenzyl chloride 2-Chlorobenzyl chloride 4-Chlorobenzyl chloride
(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride

1of2

LoreclezoleHCl 1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole 1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole R-72063 (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride 1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]- γ-Aminobutyric acid Receptor,R 72063,Inhibitor,GABA Receptor,Loreclezole,Gamma-aminobutyric acid Receptor,R72063,R-72063,inhibit (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole Loreclezole, 10 mM in DMSO Loreclezole 117857-45-1 C10H6Cl3N3HCl C10H6Cl3N3 GABA/Glycine receptor