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2,1,3-Benzothiadiazole

2,1,3-Benzothiadiazole Structure
2,1,3-Benzothiadiazole structure
CAS No.
273-13-2
Chemical Name:
2,1,3-Benzothiadiazole
Synonyms
Benzo[c][1,2,5]thiadiazole;Benzo[1,2,5]thiadiazole;2-Thia-1,3-diaza-2H-isoindene;PIAZTHIOLE;Benzisothiadiazole;BENZO-2,1,3-THIADIAZOLE;3-Benzothiadiazole;2,1,3-BENZOTHIADIAZOLE;Benzo-2,1,3-thiadiozole;Benzo-2-thia-1,3-diazole
CBNumber:
CB7109627
Molecular Formula:
C6H4N2S
Molecular Weight:
136.17
MDL Number:
MFCD00005809
MOL File:
273-13-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:27:02
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2,1,3-Benzothiadiazole Properties

Melting point 42-44 °C (lit.)
Boiling point 206 °C (lit.)
Density 1.323 (estimate)
refractive index 1.5300 (estimate)
Flash point 203 °F
storage temp. Sealed in dry,Room Temperature
solubility Solubility in methanol almost transparent.
form Low Melting Solid
pka 0.37±0.33(Predicted)
color Colorless to white to pale yellow
BRN 112408
InChI InChI=1S/C6H4N2S/c1-2-4-6-5(3-1)7-9-8-6/h1-4H
InChIKey PDQRQJVPEFGVRK-UHFFFAOYSA-N
SMILES N1=C2C=CC=CC2=NS1
CAS DataBase Reference 273-13-2(CAS DataBase Reference)
FDA UNII 8FTH8AJA9H
NIST Chemistry Reference 2,1,3-Benzothiadiazole(273-13-2)
EPA Substance Registry System 2,1,3-Benzothiadiazole (273-13-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P302+P352-P305+P351+P338-P362+P364
PPE Eyeshields, Gloves, type N95 (US)
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-26
WGK Germany  3
RTECS  DM2580000
TSCA  TSCA listed
HS Code  29349990
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

2,1,3-Benzothiadiazole price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B10900 2,1,3-Benzothiadiazole 98% 273-13-2 5g $53.9 2026-04-30 Buy
Sigma-Aldrich B10900 2,1,3-Benzothiadiazole 98% 273-13-2 25g $256 2026-04-30 Buy
TCI Chemical B0921 2,1,3-Benzothiadiazole >99.0%(GC) 273-13-2 10g $51 2026-04-30 Buy
TCI Chemical B0921 2,1,3-Benzothiadiazole >99.0%(GC) 273-13-2 25g $101 2026-04-30 Buy
Usbiological 264217 2,1,3-Benzothiadiazole Asreported 273-13-2 50g $393 2026-06-03 Buy
Product number Packaging Price Buy
B10900 5g $53.9 Buy
B10900 25g $256 Buy
B0921 10g $51 Buy
B0921 25g $101 Buy
264217 50g $393 Buy

2,1,3-Benzothiadiazole Chemical Properties,Uses,Production

Chemical Properties

Colorless to light brown solid

Uses

The product is used as an industrial solvent, and pharmaceutical intermediates for organic synthesis and used nitrocellulose and other resin, wax, fatty, dyes and other solvents.

Uses

2,1,3-Benzothiadiazole is a chemical reagent used in the synthesis of supramolecules as well as the synthesis of benzothiadiazole derivatives via cross coupling.

Reactions

2,1,3-benzothiadiazole undergoes the standard chemistry of aromatic compounds, for example readily forming nitro and chloro derivatives.Under reducing conditions, it can be converted back to the 1,2-diaminobenzene compounds from which they were prepared.

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 676, 1962 DOI: 10.1021/jo01049a536

Synthesis

o-Phenylenediamine

95-54-5

2,1,3-Benzothiadiazole

273-13-2

General procedure for the synthesis of 2,1,3-benzothiadiazole from o-phenylenediamine: 1,2-diaminobenzene (3.250 g, 30.05 mmol) and triethylamine (18 mL, 130.0 mmol) were dissolved in dichloromethane (20 mL). A solution of sulfuryl chloride (7.0 mL, 96.00 mmol) in dichloromethane (10 mL) was added dropwise with stirring. After completion of the reaction, the solvent was removed by rotary evaporator and the combined organic layers were concentrated under vacuum to afford the target product 2,1,3-benzothiadiazole (3.956 g, 97% yield). The melting point of the product was 43 °C. 1H NMR (CDCl3, 400 MHz, TMS) δ: 8.04-8.00 (m, 2H), 7.62-7.57 (m, 2H).

References

[1] Dyes and Pigments, 2016, vol. 124, p. 268 - 276
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989, vol. 25, # 11, p. 1303 - 1307
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1989, # 11, p. 1555 - 1558
[4] Tetrahedron, 2005, vol. 61, # 46, p. 10975 - 10982
[5] Tetrahedron Letters, 2005, vol. 46, # 40, p. 6843 - 6846

2,1,3-Benzothiadiazole Preparation Products And Raw materials

Raw materials

o-Phenylenediamine 1,2-Benzoquinone dioxime Thionyl chloride Triethylamine Dichloromethane

Preparation Products

2,1,3-Benzothiadiazole Suppliers

Global( 363)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Buddy Chemical Technology Co., Ltd. 18351236123 buddychem@foxmail.com China 232 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Changzhou Buddy Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

Related Questions

Ask a question
Q:How to prepare 2,1,3-Benzothiadiazole?Anonymous - Aug 15,2025
A:2,1,3-benzothiadiazole (BTD) is an important nucleus used in the chemistry of photoluminescent compounds and applicable for light technology. It is readily prepared in at least 85% yield from o-phenylenediamine by reaction with two equivalents of thionyl chloride in pyridine.

View Lastest Price from 2,1,3-Benzothiadiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,1,3-Benzothiadiazole pictures 2026-09-02 2,1,3-Benzothiadiazole
273-13-2
 $5.00-10.00 1KG 99% Henan Fengda Chemical Co., Ltd
2,1,3-Benzothiadiazole pictures 2026-06-30 2,1,3-Benzothiadiazole
273-13-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2, 1, 3-Benzothiadiazole pictures 2026-05-28 2, 1, 3-Benzothiadiazole
273-13-2
 $10.70 10KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

2,1,3-Benzothiadiazole Spectrum

2,1,3-Benzothiadiazole(273-13-2)MS2,1,3-Benzothiadiazole(273-13-2)1HNMR2,1,3-Benzothiadiazole(273-13-2)IR12,1,3-Benzothiadiazole(273-13-2)IR22,1,3-Benzothiadiazole(273-13-2)Raman2,1,3-Benzothiadiazole(273-13-2)ESR

273-13-2(2,1,3-Benzothiadiazole)Related Search:

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3,4-Benzo-1,2,5-thiadiazole Benzisothiadiazole PIAZTHIOLE 2,1,3-BENZOTHIADIAZOLE 3,4-Benzo-1,2,5-thiodiazol 2.1.3-BENZOTHIADIAZOLE 99% 2,1,3-Benzothiadiazole,Piazthiole Benzo-2,1,3-thiadiozole Benzo-2-thia-1,3-diazole 3-Benzothiadiazole 2,1,3-Benzothiadiazole,98% 2,1,3-Benzothiadiazole > 2,1,3-Benzothiadiazole ISO 9001：2015 REACH CAS273-13-2 2,1,3-Benzothiadiazole Hydrochlorothiazide Impurity: 2,1,3-Benzothiadiazole 2-Thia-1,3-diaza-2H-isoindene Benzo[1,2,5]thiadiazole Benzo[c][1,2,5]thiadiazole BENZO-2,1,3-THIADIAZOLE 273-13-2 C6H4N2S Building Blocks Perchlorates Oxidation Thiadiazoles Synthetic Reagents Heterocyclic Building Blocks Medical Intermediates