Chlorozotocin
- CAS No.
- 54749-90-5
- Chemical Name:
- Chlorozotocin
- Synonyms
- CZT;DCNU;CHLZ;CCRIS 879;NCS-178248;NCS-D-254157;Chlorozotocin;2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE;D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
- CBNumber:
- CB71178262
- Molecular Formula:
- C9H16ClN3O7
- Molecular Weight:
- 313.69
- MDL Number:
- MFCD00866505
- MOL File:
- 54749-90-5.mol
- MSDS File:
- SDS
| Melting point | 147-148° (dec with the evolution of gas); mp 140-141° (dec) |
|---|---|
| Boiling point | 119.3°C (rough estimate) |
| Density | 1.6475 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| pka | 9.08±0.46(Predicted) |
| FDA UNII | 3053LTY75Z |
| Proposition 65 List | Chlorozotocin |
| NCI Drug Dictionary | chlorozotocin |
| IARC | 2A (Vol. 50) 1990 |
| EPA Substance Registry System | Chlorozotocin (54749-90-5) |
SAFETY
Risk and Safety Statements
| RIDADR | 3249 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 54749-90-5(Hazardous Substances Data) |
Chlorozotocin Chemical Properties, Uses, Production
Chemical Properties
Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).
Uses
Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).
Definition
ChEBI: Chlorozotocin is an amino sugar.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.
Carcinogenicity
Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.
Chlorozotocin Preparation Products And Raw materials
Raw materials
Preparation Products
Chlorozotocin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35405 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| PT CHEM GROUP LIMITED | 58 |
View Latest Price from Chlorozotocin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Chlorozotocin
54749-90-5
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- Chlorozotocin
54749-90-5
- $1520.00-2500.00
- TargetMol Chemicals Inc.
