2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-
![2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Structure](CAS/20211123/GIF/2582816-37-1.gif)
- CAS No.
- 2582816-37-1
- Chemical Name:
- 2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-
- Synonyms
- 2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-
- CBNumber:
- CB711920648
- Molecular Formula:
- C19H14FN5OS
- Molecular Weight:
- 379.41
- MDL Number:
- MOL File:
- 2582816-37-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0433348 | XT2 99.60% | 2582816-37-1 | 5mg | $921 | 2026-06-04 | Buy |
| ChemScene | CS-0433348 | XT2 99.60% | 2582816-37-1 | 10mg | $1408 | 2026-06-04 | Buy |
| ChemScene | CS-0433348 | XT2 99.60% | 2582816-37-1 | 25mg | $2394 | 2026-06-04 | Buy |
| ChemScene | CS-0433348 | XT2 99.60% | 2582816-37-1 | 50mg | $3591 | 2026-06-04 | Buy |
| ChemScene | CS-0433348 | XT2 99.60% | 2582816-37-1 | 100mg | $5362 | 2026-06-04 | Buy |
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Chemical Properties, Uses, Production
Uses
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1]. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1].
References
[1]. Li Z, et al. Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. J Med Chem. 2020;63(8):4388-4407.
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8041 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
