ChemicalBook >> CAS DataBase List >>Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- structure

CAS No.: 2769753-47-9

Chemical Name:: Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-

Synonyms: DB0614;DB0614/2769753-47-9;N-(3-(2-((4-(4-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)piperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide;N-[3-[2-[[4-[4-[5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]methanesulfonamide;Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-

CBNumber:: CB712106975

Molecular Formula:: C41H42N8O7S2

Molecular Weight:: 822.96

MDL Number:

MOL File:: 2769753-47-9.mol

MSDS File:: SDS

Last updated:2026-05-28 02:27:29

Request For Quotation

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Properties

Density	1.437±0.06 g/cm3(Predicted)
pka	7.85±0.10(Predicted)
form	Solid
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0609898	DB0614 96.07%	2769753-47-9	1mg	$282	2026-06-04	Buy
ChemScene	CS-0609898	DB0614 96.07%	2769753-47-9	5mg	$563	2026-06-04	Buy
ChemScene	CS-0609898	DB0614 96.07%	2769753-47-9	10mg	$791	2026-06-04	Buy
ApexBio Technology	BA3419	DB0614	2769753-47-9	1mg	$234	2026-05-06	Buy
ApexBio Technology	BA3419	DB0614	2769753-47-9	5mg	$585	2026-05-06	Buy

Product number	Packaging	Price	Buy
CS-0609898	1mg	$282	Buy
CS-0609898	5mg	$563	Buy
CS-0609898	10mg	$791	Buy
BA3419	1mg	$234	Buy
BA3419	5mg	$585	Buy

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Chemical Properties, Uses, Production

Uses

DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1][2].(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))

IC 50

CDK6; CDK16/Cyclin Y; ULK1; Aurora Kinase; SIK2; LIMK2

References

[1] SeongShick Ryu, et al. Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9[J]. Current Research in Chemical Biology. 2021. 1:100008.
[2] William Thomas Darlow, et al. Discovery of NEK9 and Aurora A PROTACs Using a Proteomics-Based Screening Approach. The Institute of Cancer Research. 2022.
[3] GRAY, Nathanael S. Compounds for targeted protein degradation of kinases. WO2022093742. 2022/093742

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	959	58
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	992	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58

Supplier	Advantage
Shanghai Chaolan Chemical Technology Center	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
Suzhou Chenrui Biotechnology Co. LTD	58
Bide Pharmatech Ltd.	58

2769753-47-9 (Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-) Related Search:

CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) Erastin CDK2 Protein, HUMAN (HIS) PCTAIRE1 Protein, Human (sf9, GST)

CDK9 Protein, Human (sf9, GST)

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DB0614 N-(3-(2-((4-(4-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)piperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide DB0614/2769753-47-9 Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- N-[3-[2-[[4-[4-[5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]methanesulfonamide 2769753-47-9 C41H42N8O7S2