1-(2-Chloro-ethyl)-4-methyl-piperazine
- CAS No.
- 5753-26-4
- Chemical Name:
- 1-(2-Chloro-ethyl)-4-methyl-piperazine
- Synonyms
- 1-(2-Chloroethyl)-4-Methylpiperazine dihydrochloride;AKOS BB-5271;1-(2-Chloroethyl);-4-methylpiperazine dihydrochloride;6-Piperazinecarboxamide,N,N-dimethyl-;1-(2-Chloro-ethyl)-4-methyl-piperazine;1-(2-CHLOROETHYL)-4-METHYLPIPERAZINE 2HCL;1-(2-Chloroethyl)-4-methylpiperazine DiHCl;1-chloro-2-(4-methyl-1-piperazinyl)ethane dihydrochloride
- CBNumber:
- CB7130638
- Molecular Formula:
- C7H15ClN2
- Molecular Weight:
- 162.66
- MDL Number:
- MFCD17926367
- MOL File:
- 5753-26-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
1-(2-Chloro-ethyl)-4-methyl-piperazine price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 56639 | 1-(2-CHLOROETHYL)-4-METHYLPIPERAZINE 2HCL 97% | 5753-26-4 | 0.25G | $41 | 2026-04-30 | Buy |
| AstaTech | 56639 | 1-(2-CHLOROETHYL)-4-METHYLPIPERAZINE 2HCL 97% | 5753-26-4 | 0.5G | $69 | 2026-04-30 | Buy |
| AstaTech | 56639 | 1-(2-CHLOROETHYL)-4-METHYLPIPERAZINE 2HCL 97% | 5753-26-4 | 1G | $122 | 2026-04-30 | Buy |
| Matrix Scientific | 090628 | 1-(2-Chloroethyl)-4-methylpiperazinedihydrochloride | 5753-26-4 | 5.00g | $142 | 2026-05-18 | Buy |
| Matrix Scientific | 090628 | 1-(2-Chloroethyl)-4-methylpiperazinedihydrochloride | 5753-26-4 | 10.00g | $235 | 2026-05-18 | Buy |
1-(2-Chloro-ethyl)-4-methyl-piperazine Chemical Properties, Uses, Production
Synthesis
109-01-3
107-04-0
5753-26-4
The general procedure for the synthesis of 1-(2-chloroethyl)-4-methylpiperazine dihydrochloride from N-methylpiperazine and 1-bromo-2-chloroethane was as follows: 10 mL of a 25% NaOH solution and 1 mL (9 mmol) of N-methylpiperazine were added sequentially to a dry reaction flask. The mixture was heated to 50 °C and then 1.8 mL (18 mmol) of 1-bromo-2-chloroethane was added slowly and dropwise with stirring. The reaction mixture was kept at 50 °C for 6 hours with stirring. After the reaction was completed, the mixture was cooled to room temperature. The reaction mixture was extracted with ethyl acetate (3 x 20 mL), the organic phases were combined, washed with saturated NaCl solution (20 mL), and then dried over anhydrous Na2SO4. The desiccant was removed by filtration and the filtrate was concentrated to dryness under reduced pressure. A small amount of ethanol/NaOH solution was added dropwise to the residue, and the mixture was shaken and placed in a refrigerator overnight. Finally, the mixture was concentrated to dryness under reduced pressure to give 0.43 g of white solid product in 23% yield. The melting point of the product was 227-230 °C.
References
[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0064; 0065
1-(2-Chloro-ethyl)-4-methyl-piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Song Yuan Chemical Technology Co., Ltd. | 010-1234567 18521000990 | sonyuanchemical@163.com | China | 6467 | 50 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2936 | 56 |
