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ChemicalBook >> CAS DataBase List >>1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Structure
1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one structure
CAS No.
28544-83-4
Chemical Name:
1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one
Synonyms
1,2,3,4-Tetrahydro-1,4-benzodiazepin-5-one;1,2,3,4-tetrahydro-5H-1,4-Benzodiazepin-5-one;1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one;3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one;5H-1,4-Benzodiazepin-5-one, 1,2,3,4-tetrahydro-
CBNumber:
CB71337135
Molecular Formula:
C9H10N2O
Molecular Weight:
162.19
MDL Number:
MFCD09832126
MOL File:
28544-83-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
1,2,3,4-Tetrahydrobenzo(E)(1,4)diazepin-5-one T205683 500mg $265
1,2,3,4-TETRAHYDROBENZO(E)(1,4)DIAZEPIN-5-ONE 95.00% CHM0380374 5MG $502.79
3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 119704 1g $630
3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 119704 250mg $252
3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 119704 5g $1764
More product size
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1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Properties

Melting point 143-145 °C
Boiling point 436.0±25.0 °C(Predicted)
Density 1.137±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 14.00±0.20(Predicted)
Appearance White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H302-H315-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T205683 1,2,3,4-Tetrahydrobenzo(E)(1,4)diazepin-5-one 28544-83-4 500mg $265 2021-12-16 Buy
American Custom Chemicals Corporation CHM0380374 1,2,3,4-TETRAHYDROBENZO(E)(1,4)DIAZEPIN-5-ONE 95.00% 28544-83-4 5MG $502.79 2021-12-16 Buy
Matrix Scientific 119704 3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 28544-83-4 1g $630 2021-12-16 Buy
Matrix Scientific 119704 3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 28544-83-4 250mg $252 2021-12-16 Buy
Matrix Scientific 119704 3,4-Dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 95+% 28544-83-4 5g $1764 2021-12-16 Buy
Product number Packaging Price Buy
T205683 500mg $265 Buy
CHM0380374 5MG $502.79 Buy
119704 1g $630 Buy
119704 250mg $252 Buy
119704 5g $1764 Buy

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Chemical Properties,Uses,Production

Synthesis

Methyl 2-chlorobenzoate

610-96-8

Ethylenediamine

107-15-3

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one

28544-83-4

Methyl 2-chlorobenzoate (5.00 g, 29.0 mmol), ethylenediamine (8.81 g, 146.7 mmol) and anhydrous potassium carbonate (8.10 g, 58.6 mmol) were dissolved in N,N-dimethylformamide (DMF, 100 mL) under nitrogen protection. The reaction mixture was stirred at room temperature for the reaction. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the DMF. water was added to the residue and extracted three times with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give a black residue. The residue was purified by silica gel column chromatography using gradient elution with ethyl acetate/petroleum ether (20-50%) to afford the white solid product 3,4-dihydro-1H-benzo[e][1,4]diazepan-5(2H)-one (2.5 g, 52.6% yield).

References

[1] Patent: CN108498520, 2018, A. Location in patent: Paragraph 0025; 0027; 0028; 0029; 0030

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one synthesis

610-96-8
107-15-3
28544-83-4
Synthesis of 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one from Methyl 2-chlorobenzoate and Ethylenediamine

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Preparation Products And Raw materials

Raw materials

Methyl 2-chlorobenzoate Ethylenediamine N,N-Dimethylformamide Potassium carbonate

Preparation Products

2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Suppliers

Global( 34)Suppliers
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Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10996 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 5844 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7865 55
HBCChem, Inc. +1-510-219-6317 sales@hbcchem.com United States 10648 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
DebyeTec.com Inc. 18086626237 15327221536; sales@debyesci.com China 3001 56
ShangHai Movin Pharmaceutical Co., Ltd. 13681854265 info@moenpharm.com China 509 55
Supplier Advantage
Career Henan Chemica Co 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shanghai Hanhong Scientific Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Shanghai Raise Chemical Technology Co.,Ltd 55
HBCChem, Inc. 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
DebyeTec.com Inc. 56
ShangHai Movin Pharmaceutical Co., Ltd. 55

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Spectrum

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one(28544-83-4)1HNMR

28544-83-4(1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one)Related Search:

7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE CLOBAZAM 8-CARBOXYLIC-3H-1,4-BENZODIAZEPIN-2,5-(1H,4H)-DIONE 3-METHYL-1,3,4,5-TETRAHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE
4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE 7-BROMO-1,4-BENZODIAZEPIN-2,5-DIONE 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one 7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione 1,5-Dihydro-benzo[b][1,4]diazepine-2,4-dione
(S)-(+)-2,3-DIHYDRO-1H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE-5,11(10H,11AH)-DIONE 4-METHYL-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE BUTTPARK 7\07-35 asperlicin C N,2-dimethyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carboxamide
5-[(4-CHLORO-3-NITROPHENYL)SULFONYL]-4-METHYL-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-2-ONE BUTTPARK 7\07-31 asperlicin E

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1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one 1,2,3,4-tetrahydro-5H-1,4-Benzodiazepin-5-one 3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one 1,2,3,4-Tetrahydro-1,4-benzodiazepin-5-one 5H-1,4-Benzodiazepin-5-one, 1,2,3,4-tetrahydro- 28544-83-4