(2-Bromomethylphenyl)boronic acid, pinacol ester
- CAS No.
- 377780-72-8
- Chemical Name:
- (2-Bromomethylphenyl)boronic acid, pinacol ester
- Synonyms
- 2-bromethylbenzeneboronic acidolester;2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetra;(2-BROMOMETHYLPHENYL)BORONIC ACID, PICOL ESTER;(2-Bromomethylphenyl)boronic acid, pinacol ester;2-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER;2-(Bromomethyl)benzeneboronicacidpinacolcyclicester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide;2-(2-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[2-(bromomethyl)phenyl]-4,4,5,5-tetramethyl-;2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide
- CBNumber:
- CB7134151
- Molecular Formula:
- C13H18BBrO2
- Molecular Weight:
- 297
- MDL Number:
- MFCD01632210
- MOL File:
- 377780-72-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 78-80°C |
|---|---|
| Boiling point | 360.6±25.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly) |
| form | solid |
| color | white to off-white |
| InChI | 1S/C13H18BBrO2/c1-12(2)13(3,4)17-14(16-12)11-8-6-5-7-10(11)9-15/h5-8H,9H2,1-4H3 |
| InChIKey | ROIXSNLOYHDYBP-UHFFFAOYSA-N |
| SMILES | CC1(C)OB(OC1(C)C)c2ccccc2CBr |
| CAS DataBase Reference | 377780-72-8(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| TSCA | No | |||||||||
| HS Code | 2931900090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
(2-Bromomethylphenyl)boronic acid, pinacol ester price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 716235 | 2-Bromomethylphenylboronic acid pinacol ester 95% | 377780-72-8 | 1g | $192 | 2026-04-30 | Buy |
| TCI Chemical | T3393 | 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide >98.0%(GC)(T) | 377780-72-8 | 1g | $62 | 2026-04-30 | Buy |
| TCI Chemical | T3393 | 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide >98.0%(GC)(T) | 377780-72-8 | 5g | $218 | 2026-04-30 | Buy |
| Usbiological | 416358 | 2-Bromomethylphenylboronic Acid Pinacol Ester | 377780-72-8 | 250mg | $326 | 2026-06-03 | Buy |
| Usbiological | 416358 | 2-Bromomethylphenylboronic Acid Pinacol Ester | 377780-72-8 | 500mg | $410 | 2026-06-03 | Buy |
(2-Bromomethylphenyl)boronic acid, pinacol ester Chemical Properties,Uses,Production
Uses
2-Bromomethylphenylboronic Acid Pinacol Ester is an intermediate used to prepare [(fluorophenylcarbamoyl)pyridinylsulfanylmethyl]phenylboronic acid and noncompetitive boronic acid antagonist of CXCR1 and CXCR2.
Synthesis
76-09-5
16419-60-6
377780-72-8
To a three-neck flask equipped with a Dean-Stark splitter was added 30 mL of toluene followed by 2-methylphenylboronic acid (0.21 g, 1.55 mmol) and pinacol (0.22 g, 1.86 mmol). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was washed three times with 30 mL of water to remove unreacted pinacol and phenylboronic acid. The organic phase was separated and the toluene solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was dissolved in 50 mL of dichloromethane and washed again with 30 mL of water. Anhydrous sodium sulfate was added to the organic phase to dry, and the dried solution was evaporated under reduced pressure to give 0.32 g of crude product. The resulting crude product (0.32 g, 1.47 mmol), N-bromosuccinimide (NBS, 0.39 g, 2.2 mmol) and azobisisobutyronitrile (AIBN, 0.003 g, 0.018 mmol) were dissolved in 10 mL of acetonitrile. The reaction solution was refluxed at 90 °C for 2 hours. After the reaction was completed, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using petroleum ether (60~90 °C)/ethyl acetate (v/v = 1:1) as eluent to obtain the target product 2-bromoethylphenylboronic acid pinacol ester as white solid (0.53 g, 80% yield).
References
[1] Patent: CN107383078, 2017, A. Location in patent: Paragraph 0058; 0063; 0064; 0065; 0066; 0067; 0068
(2-Bromomethylphenyl)boronic acid, pinacol ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Lastest Price from (2-Bromomethylphenyl)boronic acid, pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | (2-Bromomethylphenyl)boronic acid pinacol ester
377780-72-8
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2021-07-13 | (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
377780-72-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
377780-72-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (2-Bromomethylphenyl)boronic acid pinacol ester
377780-72-8
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
377780-72-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
377780-72-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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