ALK-IN-21
- CAS No.
- 2901889-01-6
- Chemical Name:
- ALK-IN-21
- Synonyms
- ALK-IN-21;4-Thiomorpholinecarbodithioic acid, 2-[4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]-2-oxoethyl ester, 1,1-dioxide
- CBNumber:
- CB714133605
- Molecular Formula:
- C35H45ClN6O6S4
- Molecular Weight:
- 809.49
- MDL Number:
- MOL File:
- 2901889-01-6.mol
- MSDS File:
- SDS
ALK-IN-21 Chemical Properties, Uses, Production
Uses
ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].
References
[1] Xinyue Wang, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors. Bioorg Med Chem. 2022 Jul 15;66:116794. DOI:10.1016/j.bmc.2022.116794
ALK-IN-21 Preparation Products And Raw materials
Raw materials
Preparation Products
ALK-IN-21 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
