3-isobutylglutaric anhydride
- CAS No.
- 185815-59-2
- Chemical Name:
- 3-isobutylglutaric anhydride
- Synonyms
- PREGABALIN DIONE IMP;Pregabalin Impurity 71;Pregabalin Pyrandione IMP;PREGABALIN DIONE IMPURITY;3-isobutylglutaric anhydride;Pregabalin Pyrandione Impurity;4-(2-methylpropyl)oxane-2,6-dione;4-isobutyl-dihydro-3H-pyran-2,6-dione;4-Isobutyldihydro-2H-pyran-2,6(3H)-dione;3-isobutylglutaric anhydride ISO 9001：2015 REACH
- CBNumber:
- CB71459437
- Molecular Formula:
- C9H14O3
- Molecular Weight:
- 170.21
- MDL Number:
- MFCD27946568
- MOL File:
- 185815-59-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2917198090 |
3-isobutylglutaric anhydride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 426155 | 3-Isobutylglutaric Anhydride | 185815-59-2 | 1g | $446 | 2026-06-03 | Buy |
| Usbiological | 426155 | 3-Isobutylglutaric Anhydride | 185815-59-2 | 10g | $2400 | 2026-06-03 | Buy |
| Apolloscientific | OR315740 | 3-Isobutylglutaric anhydride >98% | 185815-59-2 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315740 | 3-Isobutylglutaric anhydride >98% | 185815-59-2 | 100g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR315740 | 3-Isobutylglutaric anhydride >98% | 185815-59-2 | 500g | $98 | 2026-06-04 | Buy |
3-isobutylglutaric anhydride Chemical Properties, Uses, Production
Uses
3-Isobutylglutaric anhydride is an impurity of Pregabalin (P704800), a ligand for the alpha-2-delta subunit of voltage-gated calcium channels that exhibits anticonvulsant and analgesic activity.
Synthesis
75143-89-4
185815-59-2
General procedure for the synthesis of 4-isobutyldihydro-2H-pyran-2,6(3H)-dione from 3-isobutylglutaric acid: 3-isobutylglutaric acid (50 g, 266 mmol) was dissolved in propionic anhydride (130 ml), and the reaction mixture was heated and refluxed for 6 h at 140-145 °C. Upon completion of the reaction, propionic acid and unreacted propionic anhydride were removed by distillation under reduced pressure (30-60 °C/15 mm Hg). Subsequently, the product was collected at 100-105 °C/0.5 mm Hg to afford 4-isobutyldihydro-2H-pyran-2,6(3H)-dione as a yellow oil in a yield of 41 g (91% yield) with a GC purity of >98% (HP-1,25 m, 70 kPa, gradient 70-240 °C, 15 °C/min). The structure of the product was confirmed by 1H NMR (CDCl3) and 13C NMR (CDCl3): 1H NMR (CDCl3), δ/ppm: 0.91 (d, 6H, J=6.6Hz), 1.27 (t, 2H, J=7.1Hz), 1.61-1.75 (m, 1H), 2.12-2.50 (m, 3H), 2.85 (dd , 2H, J1=17Hz, J2=4.1Hz); 13C NMR (CDCl3), δ/ppm: 21.86,24.23,25.89,35.43,43.08,166.48.
References
[1] Patent: WO2008/9897, 2008, A1. Location in patent: Page/Page column 8-9
[2] Patent: WO2012/93411, 2012, A2. Location in patent: Page/Page column 18
[3] Journal of the Chemical Society, 1954, p. 516,519
[4] Patent: WO2007/35789, 2007, A1. Location in patent: Page/Page column 30
[5] Patent: WO2009/4643, 2009, A2. Location in patent: Page/Page column 26
3-isobutylglutaric anhydride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Sunlight Pharmaceutical Co., Ltd | 519-83131668 15995063688 | info@sunlightchem.com | China | 100 | 69 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7917 | 65 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790;18616022633 | postmaster@tyjchem.cn | China | 1541 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Chongqing Xingcan Pharmaceutical Technology Co., Ltd. | 13594048950 19923294409 | xingcanyaoye@sina.com | China | 1590 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 |
View Latest Price from 3-isobutylglutaric anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 3-isobutylglutaric anhydride
185815-59-2
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-04-04 | 3-isobutylglutaric anhydride
185815-59-2
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-02-26 | 3-isobutylglutaric anhydride
185815-59-2
|
10g | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-isobutylglutaric anhydride
185815-59-2
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 3-isobutylglutaric anhydride
185815-59-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-isobutylglutaric anhydride
185815-59-2
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
